Results 101 to 110 of about 605,792 (294)

Quad‐SPIM: A High‐Speed, Multi‐Color Light‐Sheet Microscope for 3D Imaging of Large Cleared Human Brain Tissues

open access: yesLaser &Photonics Reviews, EarlyView.
A high‐speed, multi‐color light‐sheet microscope, named quad‐SPIM, enables rapid three dimensional (3D) imaging of large cleared human brain samples with simultaneous four‐channel acquisition. This custom‐built system achieves subcellular resolution across centimeter‐scale volumes, maintaining high image quality.
Laura Perego   +11 more
wiley   +1 more source

Octreotide Does Not Inhibit Proliferation in Five Neuroendocrine Tumor Cell Lines [PDF]

open access: yes, 2018
Somatostatin analogs (SSA) are well-established antisecretory drugs in functionally active neuroendocrine tumors (NET). Two placebo-controlled trials have recently demonstrated significant improvement of progression-free survival under SSA treatment ...
Exner, Samantha   +3 more
core   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

open access: yesThe Chemical Record, EarlyView.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos   +3 more
wiley   +1 more source

Long-term treatment of somatostatin analog-refractory growth hormone-secreting pituitary tumors with pegvisomant alone or combined with long-acting somatostatin analogs: a retrospective analysis of clinical practice and outcomes

open access: yesJournal of experimental & clinical cancer research : CR, 2013
BackgroundPegvisomant (PEGV) is widely used, alone or with somatostatin analogs (SSA), for GH-secreting pituitary tumors poorly controlled by SSAs alone.
A. Bianchi   +14 more
semanticscholar   +1 more source

Meningioma: Novel Diagnostic and Therapeutic Approaches

open access: yesBiomedicines
Background/Objectives: Meningiomas are the most common intracranial tumors. Surgery and radiation therapy are the cornerstones of treatment and no standard of care therapy exists for refractory meningiomas. This manuscript aims to provide a comprehensive
Carlen A. Yuen   +3 more
doaj   +1 more source

Somatostatin Analogs in the Medical Management of Occult Bleeding of the Lower Digestive Tract

open access: yesGastroenterology Research and Practice, 2015
The management of occult bleeding from the lower digestive tract can be very challenging. In cases of identified angiodysplasia, the first line management options can be limited by a number of clinical or anatomical factors and an alternative approach ...
Julie Martin-Grace, Gianluca Tamagno
doaj   +1 more source

Long-Term Disease Control of a Non-Operable Neuroendocrine Tumor of the Lung with Lanreotide: A Case Study

open access: yesCase Reports in Oncology, 2012
Bronchopulmonary neuroendocrine tumors (NETs) are malignant tumors that represent approximately 20% of all lung cancers. The therapeutic option for advanced or metastatic bronchopulmonary NETs is mainly palliation of symptoms; options need to be ...
F. Van Fraeyenhove   +8 more
doaj   +1 more source

Psilocybin as a novel treatment for chronic pain

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey   +3 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Agonists, Antagonists and Receptors of Somatostatin: Pathophysiological and Therapeutical Implications in Neoplasias

open access: yesCurrent Issues in Molecular Biology
Somatostatin is a peptide that plays a variety of roles such as neurotransmitter and endocrine regulator; its actions as a cell regulator in various tissues of the human body are represented mainly by inhibitory effects, and it shows potent activity ...
Argyrios Periferakis   +12 more
doaj   +1 more source

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