Results 81 to 90 of about 677,503 (281)

Pasireotide Long-Acting Release Treatment for Diabetic Cats with Underlying Hypersomatotropism [PDF]

, 2017
BACKGROUND: Long‐term medical management of hypersomatotropism (HS) in cats has proved unrewarding. Pasireotide, a novel somatostatin analogue, decreases serum insulin‐like growth factor 1 (IGF‐1) and improves insulin sensitivity in cats with HS when ...
Abraham, Berg, Bruns, Church, Colao, Colao, Combes, Cozzi, Dowling, Dunning, Feelders, Freda, Gadelha, Henry, Hofland, Hubina, Hussaini, Jaffe, Katznelson, Kurosaki, Lamb, Laron, Ma, Meij, Meij, Myers, Niessen, Niessen, Niessen, Patel, Petersenn, Peterson, Reubi, Reusch, Reusch, Sathyapalan, Schaefer, Scudder, Shanik, Slingerland, Slingerland, Theodoropoulou, Tyson, Zambre   +43 more
core   +3 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.

PLoS ONE, 2019
CGRP, adrenomedullin (ADM), and adrenomedullin 2 (ADM2) family peptides are important neuropeptides and hormones for the regulation of neurotransmission, vasotone, cardiovascular morphogenesis, vascular integrity, and feto‒placental development.
Chia Lin Chang, Sheau Yu Teddy Hsu
doaj   +1 more source

Modern methods of medical treatment of acromegaly

Медицинский совет, 2020
The continuing difficulty of treatment of acromegaly depends on: late diagnosis of the disease, the multiplicity of pathological variants of GH-secreting adenomas, the presence of complicated forms of the disease, and the lack of differentiated approach ...
V. S. Pronin, E. V. Pronin
doaj   +1 more source

Towards a Radio-guided Surgery with $\beta^{-}$ Decays: Uptake of a somatostatin analogue (DOTATOC) in Meningioma and High Grade Glioma

, 2014
A novel radio guided surgery (RGS) technique for cerebral tumors using $\beta^{-}$ radiation is being developed. Checking the availability of a radio-tracer that can deliver a $\beta^{-}$ emitter to the tumor is a fundamental step in the deployment of ...
BELLINI, Fabio, Bocci, Valerio, Chiodi, Giacomo, COLLAMATI, FRANCESCO, Cremonesi, Marta, DE LUCIA, Erika, FACCINI, Riccardo, Ferrari, Mahila E., Frallicciardi, Paola M., Grana, Chiara M., Marafini, Michela, Mattei, Ilaria, Morganti, Silvio, PATERA, Vincenzo, PEPE, ALESSANDRA, PIERSANTI, LUCA, PINCI, davide, Recchia, Luigi, RUSSOMANDO, ANDREA, SARTI, ALESSIO, SCIUBBA, Adalberto, SENZACQUA, MARTINA, SOLFAROLI CAMILLOCCI, ELENA, VOENA, Cecilia   +23 more
core   +1 more source

Carbon Dots for Cancer Theranostics: Synthesis Strategies, Luminescence Properties, and Advances in Bioimaging‐Guided Diagnosis and Therapy

Chemistry – A European Journal, EarlyView.
Lighting up the path to precision oncology: This review comprehensively summarizes the rational design of carbon dots (CDs), elucidating how core size, surface chemistry, and heteroatom doping dictate their luminescence mechanisms. Special emphasis is placed on engineering NIR‐II emissive CDs for deep‐tissue imaging.
Zekun Yan, Yupeng Liu, Jinyun Tan, Songnan Qu   +3 more
wiley   +1 more source

Estrogens Modulate Somatostatin Receptors Expression and Synergize With the Somatostatin Analog Pasireotide in Prostate Cells

Frontiers in Pharmacology, 2019
Prostate cancer (PC) is one of the most frequently diagnosed cancers and a leading cause of cancer-related deaths in Western society. Current PC therapies prevalently target the functions of androgen receptor (AR) and may only be effective within short ...
Valentina Rossi, Erika Di Zazzo, Giovanni Galasso, Caterina De Rosa, Ciro Abbondanza, Antonio A. Sinisi, Lucia Altucci, Antimo Migliaccio, Gabriella Castoria   +8 more
doaj   +1 more source

Targeted paclitaxel‐octreotide conjugates inhibited the growth of paclitaxel‐resistant human non‐small cell lung cancer A549 cells in vitro

Thoracic Cancer, 2021
The application of chemotherapy in non‐small cell lung cancer (NSCLC) is limited by the toxicity to normal cells and the development of multi‐drug resistance.
Yanguo Liu, Handai Xia, Yawei Wang, Wenfei Han, Jing Qin, Wenjuan Gao, Xun Qu, Xiuwen Wang   +7 more
doaj   +1 more source

Peptide receptor radionuclide therapy using radiolabeled somatostatin analogs: focus on future developments

Clinical and translational imaging, 2014
Peptide receptor radionuclide therapy (PRRT) has been shown to be an effective treatment for neuroendocrine tumors (NETs) if curative surgery is not an option. A majority of NETs abundantly express somatostatin receptors.
Sander M. Bison, M. Konijnenberg, M. Melis, Stefan E. Pool, M. Bernsen, Jaap J M Teunissen, D. Kwekkeboom, M. de Jong   +7 more
semanticscholar   +1 more source

Continuous outcome estimation in N‐of‐1 trials for accelerated decision‐making

Epilepsia, EarlyView.
Abstract Objective N‐of‐1 trials aim to determine the therapeutic effect for a single individual. This individualized approach necessitates collecting multiple data points over time through repeated alternating periods of active treatment and a comparator or control condition.
Victoria Defelippe, František Bartoš, Eric‐Jan Wagenmakers, Kees P. J. Braun, Floor E. Jansen, Willem M. Otte   +5 more
wiley   +1 more source