Results 101 to 110 of about 117,026 (248)

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Intraoperative localization of gut endocrine tumors with radiolabeled somatostatin analogs and a gamma-detecting probe

open access: yes, 1998
Gut endocrine tumors are sometimes difficult to localize by radiological techniques. Carcinoids and gastrinomas, however, possess high density of somatostatin receptors, thus, scintigraphy with radiolabeled somatostatin analogs may prove useful for ...
Carcano G.   +3 more
core   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes   +7 more
wiley   +1 more source

Positive modulation of glucagon‐like peptide 1 (GLP‐1) receptor by endogenous haemorphins with implications in glucose metabolism and diabetes

open access: yesBritish Journal of Pharmacology, EarlyView.
Haemorphins act on GLP‐1 receptor (GLP‐1R) activity and signalling in a positive allosteric manner. This leads to potentiated GLP‐1‐mediated activity and signalling, as well as insulin synthesis, which may have implications for glucose metabolism and, thereby, diabetes and obesity. (The graph was created in BioRender.com).
Farheen Badrealam Khan   +13 more
wiley   +1 more source

Antiproliferative effects of somatostatin analogs in pituitary adenomas

open access: yes, 2006
The antisecretory effects of somatostatin (SRIF) and its analogs are widely recognised and provide the basis for treatment of hormonal hypersecretion in pituitary adenomas, especially in the settings of acromegaly.
Ambrosio M. R.   +4 more
core   +1 more source

Treatment Patterns of Long-Acting Somatostatin Analogs for Neuroendocrine Tumors. [PDF]

open access: yesJ Health Econ Outcomes Res, 2023
Clarke CN   +6 more
europepmc   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

open access: yesJournal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer   +4 more
wiley   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets

open access: yesJournal of Anatomy, EarlyView.
We introduce the MacBrain Resource Center (MBRC) Collections of rhesus macaque embryonic brain tissue. Here, we illustrate histo‐ and immunohistology from our dynamically growing Collection 6, which currently contains >10,000 zoomable and downloadable images from n = 14 male and female embryos from early to late in gestation.
Valeria Mendoza‐Silva   +11 more
wiley   +1 more source

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