Results 61 to 70 of about 117,026 (248)

Functional profiling of somatostatin receptors identifies somatostatin receptor subtype 2 as a vulnerability in Succinate Dehydrogenase SDHB-deficient pheochromocytomas and paragangliomas

Molecular Biomedicine
Pheochromocytomas and Paragangliomas (PPGL) are rare neuroendocrine tumors with favorable prognosis, although a significant subset (20–25%) progress to metastasis, worsening patient prognosis.
Víctor García-Vioque, Sergio Pedraza-Arevalo, María Trinidad Moreno-Montilla, Esther Rivero-Cortés, Ricardo Blázquez-Encinas, Federica Mangili, Ester Arroba, Aura D. Herrera-Martínez, Michael D. Culler, María Ángeles Gálvez-Moreno, Anne Barlier, Luisa María Botella, Mercedes Robledo, Justo P. Castaño, Alejandro Ibáñez-Costa   +14 more
doaj   +1 more source

Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.

PLoS ONE, 2019
CGRP, adrenomedullin (ADM), and adrenomedullin 2 (ADM2) family peptides are important neuropeptides and hormones for the regulation of neurotransmission, vasotone, cardiovascular morphogenesis, vascular integrity, and feto‒placental development.
Chia Lin Chang, Sheau Yu Teddy Hsu
doaj   +1 more source

Modern methods of medical treatment of acromegaly

Медицинский совет, 2020
The continuing difficulty of treatment of acromegaly depends on: late diagnosis of the disease, the multiplicity of pathological variants of GH-secreting adenomas, the presence of complicated forms of the disease, and the lack of differentiated approach ...
V. S. Pronin, E. V. Pronin
doaj   +1 more source

Ein Ruthenium(CAAC‐5)‐Olefin‐Metathese‐Katalysator für die Biokonjugation

Angewandte Chemie, EarlyView.
Die Instabilität von Rutheniumkatalysatoren in wässrigen Lösungen schränkt die Olefinmetathese in biologischen Medien ein. Es wird über einen Ru(CAAC‐5)‐Komplex berichtet, der unter biologisch relevanten Bedingungen aktiv bleibt und die Biokonjugation mit Proteinen, Peptiden und einem künstlichen Metalloenzym ermöglicht.
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

Estrogens Modulate Somatostatin Receptors Expression and Synergize With the Somatostatin Analog Pasireotide in Prostate Cells

Frontiers in Pharmacology, 2019
Prostate cancer (PC) is one of the most frequently diagnosed cancers and a leading cause of cancer-related deaths in Western society. Current PC therapies prevalently target the functions of androgen receptor (AR) and may only be effective within short ...
Valentina Rossi, Erika Di Zazzo, Giovanni Galasso, Caterina De Rosa, Ciro Abbondanza, Antonio A. Sinisi, Lucia Altucci, Antimo Migliaccio, Gabriella Castoria   +8 more
doaj   +1 more source

Targeted radiotherapy with radiolabeled somatostatin analogs

, 2011
Targeted radiopeptide therapy with (90)Yttrium- or (177)Lutetium-labeled somatostatin analogs has been proven to improve significantly quality of life and survival in patients suffering from metastatic or unresectable neuroendocrine tumors (NETs ...
Forrer, Flavio, Flavio Forrer, Müller-Brand, Jan, Giampiero Giovacchini, Nicolas, Guillaume, Guillaume Nicolas, Giovacchini, Giampiero, Jan Müller-Brand   +7 more
core   +1 more source

SOMATOSTATIN RECEPTORS AS POTENTIALTHERAPEUTIC TARGETS IN THE TREATMENT OF ADVANCED ADRENOCORTICAL CANCER. A CASE REPORT

Сибирский онкологический журнал, 2018
Background. Adrenocortical cancer (ACC) is a rare malignancy of the adrenal cortex. Therapeutic options for advanced ACC are limited. It is necessary to study new and more effective drug combinations and tumor biological targets. The purpose of the study
A. A. Kolomeytseva, V. V. Delektorskaya, N. F. Orel, G. S. Emelianova, V. Y. Bokhian, A. A. Fedenko   +5 more
doaj   +1 more source

Targeted paclitaxel‐octreotide conjugates inhibited the growth of paclitaxel‐resistant human non‐small cell lung cancer A549 cells in vitro

Thoracic Cancer, 2021
The application of chemotherapy in non‐small cell lung cancer (NSCLC) is limited by the toxicity to normal cells and the development of multi‐drug resistance.
Yanguo Liu, Handai Xia, Yawei Wang, Wenfei Han, Jing Qin, Wenjuan Gao, Xun Qu, Xiuwen Wang   +7 more
doaj   +1 more source

A Ruthenium(CAAC‐5) Olefin Metathesis Catalyst for Bioconjugation

Angewandte Chemie International Edition, EarlyView.
The aqueous instability of ruthenium catalysts restricts olefin metathesis in biological media. A Ru(CAAC‐5) complex bearing an aniline handle is reported that remains active under biologically relevant conditions and enables bioconjugation to proteins, peptides, and an artificial metalloenzyme, providing a robust platform for olefin metathesis in ...
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

High Expression of Somatostatin Receptors 2A, 3, and 5 in Corticotroph Pituitary Adenoma

International Journal of Endocrinology, 2018
The development of somatostatin analogs for the treatment of pituitary Cushing’s disease has been based on somatostatin receptor expression analyses of small cohorts of pituitary adenomas.
Felix Behling, Jürgen Honegger, Marco Skardelly, Irina Gepfner-Tuma, Ghazaleh Tabatabai, Marcos Tatagiba, Jens Schittenhelm   +6 more
doaj   +1 more source