Results 51 to 60 of about 117,026 (248)

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

DOTA-Derivatives of Octreotide Dicarba-Analogs with High Affinity for Somatostatin sst2,5 Receptors [PDF]

, 2017
In vivo somatostatin receptor scintigraphy is a valuable method for the visualization of human endocrine tumors and their metastases. In fact, peptide ligands of somatostatin receptors (sst's) conjugated with chelating agents are in clinical use. We have
Mauro Ginanneschi, BRANCACCIO, DIEGO, Lumini, Marco, Papini, Anna M, Alfonso Carotenuto, Marco Lumini, CAROTENUTO, ALFONSO, Ginanneschi, Mauro, Anna M. Papini, NOVELLINO, ETTORE, Alessandro Pratesi, Diego Brancaccio, PAPINI, ANNA MARIA, Ettore Novellino, Pratesi, Alessandro   +14 more
core   +1 more source

Somatostatin analogs: clinical application in relation to human somatostatin receptor subtypes [PDF]

Biochemical Pharmacology, 1995
SRIFt was described originally by Krulich et al. [l] as a factor present in hypothalamic extracts capable of inhibiting GH release by cultured rat anteriorpituitarycells.Brazeauetal. [2]characterized this factor as a cyclic peptide (SS14) consisting of 14 amino acids. Several years later, a second bioactive form, an NHz-terminally extended somatostatin
Hofland, Leo J., Visser-Wisselaar, Heleen A., Lamberts, Steven W.J.   +2 more
openaire   +3 more sources

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Radiolabeled bicyclic somatostatin-based analogs: a novel class of potential radiotracers for SPECT/PET of neuroendocrine tumors

, 2010
A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin receptor (sst)-positive tumors. Bicyclic somatostatin-based radiopeptides have not been studied yet.
Andreas Mueller, Reubi, Jean Claude, Mueller, A., Mueller, Andreas, Cescato, Renzo, Mäcke, Helmut R., Rink, Hans R, Melpomeni Fani, Guillaume Nicolas, Tamma, Maria Luisa, Tamma, Maria-Luisa, Helmut R. Maecke, Maecke, Helmut R, Reubi, Jean-Claude, Hans R. Rink, Rink, H. R., Nicolas, Guillaume, Fani, Melpomeni, Maria-Luisa Tamma, Renzo Cescato, Jean Claude Reubi, Nicolas, Guillaume P.   +21 more
core   +1 more source

Early Versus Late Recurrence in Olfactory Neuroblastoma: A Multi‐Institutional Analysis of Predictive Risk Factors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory neuroblastoma (ONB) exhibits variable recurrence patterns, with significant late recurrences occurring years after treatment. We investigated cutoff periods to define late recurrence and identified predictors that distinguish patients at risk of late recurrence from those considered cured.
Alexandria Harris, Anthony Tang, Nicholas Fung, Joao Paulo Almeida, Pierre‐Olivier Champagne, Juan Fernandez‐Miranda, Paul A. Gardner, Peter Hwang, Aristotelis Kalyvas, Chirag Patel, Zara M. Patel, Maria Peris Celda, Carlos D. Pinheiro‐Neto, Olabisi Sanusi, Carl H. Snyderman, Brian D. Thorp, Jamie J. Van Gompel, Georgios Zenonos, Nathan T. Zwagerman, Diana Bell, Edward C. Kuan, Eric W. Wang, Mathew Geltzeiler, Garret Choby   +23 more
wiley   +1 more source

Management of chylous pleural and peritoneal effusions in a cirrhotic patient: A case report and review of literature

Journal of International Medical Research
This case report details the management of a patient with cirrhosis who developed chylous pleural and peritoneal effusions. The patient, with a 28-year history of untreated hepatitis B, presented with dyspnea and cough after traveling to a high-altitude ...
Xuegui Ju, Yaguang Li
doaj   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Imaging and Therapy of Neuroendocrine Tumors with Radiolabeled Somatostatin Analogs [PDF]

, 2017
Neuroendocrine tumors are a heterogeneous group of tumors, but they generally express a high number of somatostatin receptors on their cell membranes. This receptor is a target for somatostatin analogs, which can be labeled with radionuclides for both ...
Brabander, Tessa, Brabander, T. (Tessa)
core   +1 more source

Expression of Somatostatin Receptor Subtypes (SSTR-1–SSTR-5) in Pediatric Hematological and Oncological Disorders

Molecules, 2020
Hematological and oncological disorders represent leading causes of childhood mortality. Neuropeptide somatostatin (SST) has been previously demonstrated in various pediatric tumors, but limited information exists on the expression and characteristics of
Kristof Harda, Zsuzsanna Szabo, Eva Juhasz, Balazs Dezso, Csongor Kiss, Andrew V. Schally, Gabor Halmos   +6 more
doaj   +1 more source