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Somatostatin analogs for the treatment of neuroendocrine tumors
Cancer and Metastasis Reviews, 2011 Somatostatin is an important regulator of endocrine and exocrine secretion, affecting the release of many hormones. The effects of somatostatin are mediated through its interaction with one of five somatostatin receptors.
Michael D. Culler +2 more
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The Journal of Peptide Research, 2001
Abstract: Somatostatin is a hypothalamic peptide hormone that inhibits the secretion of growth hormone, glucagon, insulin, gastrin and secretin, and also plays a role in neural transmission. Because of its wide range of possible clinical applications hundreds of somatostatin analogs have been synthesized and bioassayed to date.
A, Janecka, M, Zubrzycka, T, Janecki
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Abstract: Somatostatin is a hypothalamic peptide hormone that inhibits the secretion of growth hormone, glucagon, insulin, gastrin and secretin, and also plays a role in neural transmission. Because of its wide range of possible clinical applications hundreds of somatostatin analogs have been synthesized and bioassayed to date.
A, Janecka, M, Zubrzycka, T, Janecki
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Somatostatin Analogs Inhibit Somatostatin Release*
Endocrinology, 1979To determine if, like insulin, somatostatin inhibits its own secretion from the pancreas, nonimmunoreactive analogs of somatostatin were perfused in an isolated dog pancreaticoduodenal preparation using a nonrecirculating system. [D-Trp8-D-Cys14]somatostatin, at a concentration of 200 ng/ml, blocked the response of somatostatin-like immunoreactivity ...
E, Ipp +5 more
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Current Drug Targets, 2016
Somatostatin (SST) is a cyclic hormone-release inhibitory peptide that has high binding affinity to all of its five SST receptors (SSTRs). SST negatively regulates cell proliferation and the release of multiple hormones via activation of its cognate receptors.
Lichun, Sun, David H, Coy
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Somatostatin (SST) is a cyclic hormone-release inhibitory peptide that has high binding affinity to all of its five SST receptors (SSTRs). SST negatively regulates cell proliferation and the release of multiple hormones via activation of its cognate receptors.
Lichun, Sun, David H, Coy
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Annals of Oncology, 2004 This consensus report gives a detailed description of the use of somatostatin analogs in the management of neuroendocrine tumors of the gastroenteropancreatic system.
Bertram Wiedenmann +2 more
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Use of Somatostatin and Somatostatin Analogs in a Patient with a Glucagonoma
The Journal of Clinical Endocrinology & Metabolism, 1981The effects of somatostatin (SRIF) and, for the first time in man, three of its analogs were studied in a patient with a glucagonoma. Circulating levels of glucagon were greater than 50 ng/ml (normal,
C R, Kahn +3 more
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Somatostatin-28, somatostatin-14 and somatostatin analogs: Effects on thermoregulation
Brain Research, 1981Somatostatins, somatostatin-14, somatostatin-28, and desAA [D-Trp8]-somatostatin, with differential potencies, act in the brain to reverse chemical-induced hypothermia and to produce hyperthermia. Somatostatins are more potent and loger acting than prostaglandin E2 in producing hyperthermia.
M, Brown, N, Ling, J, Rivier
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Somatostatin Analogs in the Treatment of Acromegaly
Endocrinology and Metabolism Clinics of North America, 1992Medical therapy of acromegaly with the somatostatin analog octreotide is very successful. Both clinical symptomatology and hormonal hypersecretion by the growth hormone-secreting pituitary adenomas are controlled, and peripheral IGF-I levels also return to near normal levels. Tumor shrinkage is observed in most patients.
S W, Lamberts, J C, Reubi, E P, Krenning
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Antiproliferative Effect of Somatostatin and Analogs
Chemotherapy, 2001Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects.
C, Bousquet +4 more
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Clinical Applications of Somatostatin Analogs
1985It has often been shown that tetradecapeptide somatostatin (S-14), discovered in 1973 by Brazeau et al. (1), is effective in the treatment of acromegaly, as adjunct to insulin therapy of type I diabetes, in stopping gastrointestinal bleeding, in treatment of carcinoid syndrome, etc.
P, Marbach, M, Neufeld, J, Pless
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