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Somatostatin analogs: does pharmacology impact antitumor efficacy?
Trends in Endocrinology and Metabolism, 2014 Philippe J Caron +2 more
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The Journal of Peptide Research, 2001
Abstract: Somatostatin is a hypothalamic peptide hormone that inhibits the secretion of growth hormone, glucagon, insulin, gastrin and secretin, and also plays a role in neural transmission. Because of its wide range of possible clinical applications hundreds of somatostatin analogs have been synthesized and bioassayed to date.
A, Janecka, M, Zubrzycka, T, Janecki
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Abstract: Somatostatin is a hypothalamic peptide hormone that inhibits the secretion of growth hormone, glucagon, insulin, gastrin and secretin, and also plays a role in neural transmission. Because of its wide range of possible clinical applications hundreds of somatostatin analogs have been synthesized and bioassayed to date.
A, Janecka, M, Zubrzycka, T, Janecki
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A review of the use of somatostatin analogs in oncology
OncoTargets and Therapy, 2013 Somatostatin is a neuropeptide produced by paracrine cells that are located throughout the gastrointestinal tract, lung, and pancreas, and is also found in various locations of the nervous system.
Suayib Yalcin
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Somatostatin Analogs Inhibit Somatostatin Release*
Endocrinology, 1979To determine if, like insulin, somatostatin inhibits its own secretion from the pancreas, nonimmunoreactive analogs of somatostatin were perfused in an isolated dog pancreaticoduodenal preparation using a nonrecirculating system. [D-Trp8-D-Cys14]somatostatin, at a concentration of 200 ng/ml, blocked the response of somatostatin-like immunoreactivity ...
E, Ipp +5 more
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Digestive and Liver Disease, 2019
BACKGROUND Somatostatin analogs are the backbone of neuroendocrine neoplasms treatment. Biliary stone disease is a potentially severe adverse event of somatostatin analogs: an increased incidence has been reported in somatostatin analogs-treated ...
N. Brighi +11 more
semanticscholar +1 more source
BACKGROUND Somatostatin analogs are the backbone of neuroendocrine neoplasms treatment. Biliary stone disease is a potentially severe adverse event of somatostatin analogs: an increased incidence has been reported in somatostatin analogs-treated ...
N. Brighi +11 more
semanticscholar +1 more source
Somatostatin-28, somatostatin-14 and somatostatin analogs: Effects on thermoregulation
Brain Research, 1981Somatostatins, somatostatin-14, somatostatin-28, and desAA [D-Trp8]-somatostatin, with differential potencies, act in the brain to reverse chemical-induced hypothermia and to produce hyperthermia. Somatostatins are more potent and loger acting than prostaglandin E2 in producing hyperthermia.
M, Brown, N, Ling, J, Rivier
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Clinical applications of somatostatin analogs
Trends in Endocrinology & Metabolism, 1990The somatostatin analog Sandostatin is successfully used in the treatment of metastatic endocrine pancreatic tumors, carcinoids, and acromegaly. In addition, somatostatin receptors are also present on other tumors in man, therefore making it possible to demonstrate these tumors by the administration of (123)I-coupled to a somatostatin analog.
S W, Lamberts +3 more
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Somatostatin: Analogs with Selected Biological Activities
Science, 1976[D-Cys 14 ]-Somatostatin is the first analog of somatostatin found to be more potent in inhibiting glucagon and growth hormone secretion than it is in inhibiting insulin secretion. [D-Trp 8 ]-Somatostatin is eight to ten times more potent than somatostatin in inhibiting insulin, glucagon, and
M, Brown, J, Rivier, W, Vale
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Clinical Applications of Somatostatin Analogs
1985It has often been shown that tetradecapeptide somatostatin (S-14), discovered in 1973 by Brazeau et al. (1), is effective in the treatment of acromegaly, as adjunct to insulin therapy of type I diabetes, in stopping gastrointestinal bleeding, in treatment of carcinoid syndrome, etc.
P, Marbach, M, Neufeld, J, Pless
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Somatostatin Analogs Inhibit Somatostatin Secretion from Cultured Hypothalamus Cells
Neuroendocrinology, 1984The effect of somatostatin (SRIF) analogs on the secretion of radioimmunoassayable SRIF (SRIF-LI) was studied in the model system of fetal rat hypothalamus cells maintained in long-term, primary dispersed culture. These experiments exploited the biologic activity of certain synthetic SRIFs which cross-react poorly in our standard RIA for SRIF ...
R A, Peterfreund, W W, Vale
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