Results 211 to 220 of about 675,123 (288)

Somatostatin analogs

The Journal of Peptide Research, 2001
Abstract:  Somatostatin is a hypothalamic peptide hormone that inhibits the secretion of growth hormone, glucagon, insulin, gastrin and secretin, and also plays a role in neural transmission. Because of its wide range of possible clinical applications hundreds of somatostatin analogs have been synthesized and bioassayed to date.
A, Janecka, M, Zubrzycka, T, Janecki
openaire   +2 more sources

Somatostatin Analogs Inhibit Somatostatin Release*

Endocrinology, 1979
To determine if, like insulin, somatostatin inhibits its own secretion from the pancreas, nonimmunoreactive analogs of somatostatin were perfused in an isolated dog pancreaticoduodenal preparation using a nonrecirculating system. [D-Trp8-D-Cys14]somatostatin, at a concentration of 200 ng/ml, blocked the response of somatostatin-like immunoreactivity ...
E, Ipp, J, Rivier, R E, Dobbs, M, Brown, W, Vale, R H, Unger   +5 more
openaire   +2 more sources

Biliary stone disease in patients receiving somatostatin analogs for neuroendocrine neoplasms. A retrospective observational study.

Digestive and Liver Disease, 2019
BACKGROUND Somatostatin analogs are the backbone of neuroendocrine neoplasms treatment. Biliary stone disease is a potentially severe adverse event of somatostatin analogs: an increased incidence has been reported in somatostatin analogs-treated ...
N. Brighi, G. Lamberti, I. Maggio, L. Manuzzi, C. Ricci, R. Casadei, D. Santini, C. Mosconi, A. Lisotti, V. Ambrosini, M. Pantaleo, D. Campana   +11 more
semanticscholar   +1 more source

Somatostatin-28, somatostatin-14 and somatostatin analogs: Effects on thermoregulation

Brain Research, 1981
Somatostatins, somatostatin-14, somatostatin-28, and desAA [D-Trp8]-somatostatin, with differential potencies, act in the brain to reverse chemical-induced hypothermia and to produce hyperthermia. Somatostatins are more potent and loger acting than prostaglandin E2 in producing hyperthermia.
M, Brown, N, Ling, J, Rivier
openaire   +2 more sources

Clinical applications of somatostatin analogs

Trends in Endocrinology & Metabolism, 1990
The somatostatin analog Sandostatin is successfully used in the treatment of metastatic endocrine pancreatic tumors, carcinoids, and acromegaly. In addition, somatostatin receptors are also present on other tumors in man, therefore making it possible to demonstrate these tumors by the administration of (123)I-coupled to a somatostatin analog.
S W, Lamberts, E P, Krenning, J G, Klijn, J C, Reubi   +3 more
openaire   +2 more sources

Somatostatin: Analogs with Selected Biological Activities

Science, 1976
[D-Cys 14 ]-Somatostatin is the first analog of somatostatin found to be more potent in inhibiting glucagon and growth hormone secretion than it is in inhibiting insulin secretion. [D-Trp 8 ]-Somatostatin is eight to ten times more potent than somatostatin in inhibiting insulin, glucagon, and
M, Brown, J, Rivier, W, Vale
openaire   +3 more sources

Clinical Applications of Somatostatin Analogs

1985
It has often been shown that tetradecapeptide somatostatin (S-14), discovered in 1973 by Brazeau et al. (1), is effective in the treatment of acromegaly, as adjunct to insulin therapy of type I diabetes, in stopping gastrointestinal bleeding, in treatment of carcinoid syndrome, etc.
P, Marbach, M, Neufeld, J, Pless
openaire   +2 more sources

Somatostatin Analogs Inhibit Somatostatin Secretion from Cultured Hypothalamus Cells

Neuroendocrinology, 1984
The effect of somatostatin (SRIF) analogs on the secretion of radioimmunoassayable SRIF (SRIF-LI) was studied in the model system of fetal rat hypothalamus cells maintained in long-term, primary dispersed culture. These experiments exploited the biologic activity of certain synthetic SRIFs which cross-react poorly in our standard RIA for SRIF ...
R A, Peterfreund, W W, Vale
openaire   +2 more sources

Structure-Function Relationships of Somatostatin Analogs

Hormone Research, 1988
Objective of peptide chemistry has always been the production of analogues for clinical application. Advantages sought over natural peptides are (a) reduced molecular size; (b) prolonged biological half-life, and (c) enhanced specificity. After elucidation of the active core of somatostatin a number of analogues have been synthetized.
P, Marbach, W, Bauer, U, Briner, W, Döpfner, T, Petcher, J, Pless   +5 more
openaire   +2 more sources

Extended retro‐inverso analogs of somatostatin

Biopolymers, 1983
AbstractAn extended retro‐inverso modification was introduced at the central six residues of the somatostatin molecule, the region of internal enzymatic degradations. The synthesis of the analog [Ala4,g‐Phe6‐r‐D‐Phe7‐r‐D‐Trp8‐r‐D‐Lys9‐r‐D‐Thr10‐m‐R,S‐Phe11]‐somatostatin required a unique strategy accommodating the unusual structure.
P, Pallai, S, Struthers, M, Goodman, J, Rivier, W, Vale   +4 more
openaire   +2 more sources