Results 221 to 230 of about 675,123 (288)

Cortistatin: not just another somatostatin analog

Nature Clinical Practice Endocrinology & Metabolism, 2006
Cortistatin is a member of the somatostatin family of peptide hormones. Although cortistatin and somatostatin display many structural and functional similarities, there are also notable differences including tissue distribution and receptor selectivity.
Luis, de Lecea, Justo P, Castaño
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Somatostatin analogs in ectopic corticotropin production

Metabolism, 1996
Eutopic corticotroph pituitary adenomas and adrenal cortisol-producing adenomas do not usually express somatostatin receptors. However, ectopic corticotropin (ACTH)-producing tumors often express somatostatin receptors. Thus, the octreoscan can detect and localize tumors in 80% of patients with ectopic ACTH syndrome, and so it can be used to ...
K, von Werder, O A, Muller, G K, Stalla
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Somatostatin Analogs Inhibit Neonatal Retinal Neovascularization

Experimental Eye Research, 2002
The goal of this study was to determine the effect of two somatostatin analogs, Woc4D and octreotide, on oxygen induced retinopathy in the mouse. Oxygen induced retinopathy was produced in C57BL6 mice. Octreotide and Woc4D were administered from post-natal day 12-16.
Rosemary D, Higgins, Yun, Yan, Bruce K, Schrier   +2 more
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Octreotide: A Long-Acting Somatostatin Analog

The American Journal of the Medical Sciences, 1990
One of the exciting recent developments in endocrinology research has been the introduction of the somatostatin analog, octreotide into clinical practice. Octreotide provides a new therapeutic tool for diseases in which somatostatin or somatostatin-like products are secreted abnormally.
Nancy Brown, Philip E. Johnston, Patricia Arns, Renata Bluhm, Robert A. Branch   +4 more
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Targeted Radiotherapy with Radiolabeled Somatostatin Analogs

Endocrinology and Metabolism Clinics of North America, 2011
Targeted radiopeptide therapy with (90)Yttrium- or (177)Lutetium-labeled somatostatin analogs has been proven to improve significantly quality of life and survival in patients suffering from metastatic or unresectable neuroendocrine tumors (NETs). Roughly 25% of patients achieve partial remission; progression-free survival is estimated to be 30 to 40 ...
Nicolas, Guillaume, Giovacchini, Giampiero, Müller-Brand, Jan, Forrer, Flavio   +3 more
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Antiproliferative Effect of Somatostatin and Analogs

Chemotherapy, 2001
Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects.
C, Bousquet, E, Puente, L, Buscail, N, Vaysse, C, Susini   +4 more
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Somatostatin analog treatment of pancreatic fistulas

International journal of pancreatology, 1993
In order to hasten healing of pancreatic fistulas, we have treated 11 men and one woman with octreotide, a long-lasting somatostatin analog. This agent was administered subcutaneously in doses of 0.05-0.20 mg, two to three times per day. Fistulas were secondary to pancreatic biopsy (1), pancreatic abscess drainage (2), operative injury (3), and blunt ...
S M, Barnes, B G, Kontny, R A, Prinz
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Radiolabeled somatostatin analogs in prostate cancer

Nuclear Medicine and Biology, 1997
Vapreotide (RC-160), a somatostatin analog, was labeled with 99mTC by a direct method and also by using CPTA [1,4,8,11-tetraazacyclotetradecane] as a bifunctional chelating agent. The labeled compounds were evaluated in nude mice bearing experimental human prostate cancers. In these studies, 111In-DTPA-D-Phe-Octreotide (111In-DTPA-octreotide) served as
M L, Thakur, H, Kolan, J, Li, R, Wiaderkiewicz, V R, Pallela, R, Duggaraju, A V, Schally   +6 more
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Two Types of Somatostatin Receptors Differentiated by Cyclic Somatostatin Analogs

Science, 1985
Somatostatin receptors in rat brain, pituitary, and pancreas were labeled with two radioiodinated analogs of somatostatins 14 and 28. Two cyclic analogs of somatostatin, SMS201-995 and cyclo(Ala-Cys-Phe-D-Trp-Lys-Thr-Cys), showed biphasic displacement of binding to somatostatin receptors by these radioligands.
V T, Tran, M F, Beal, J B, Martin
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Intrathecal somatostatin, somatostatin analogs, substance P analog and dynorphin A cause comparable neurotoxicity in rats

Neuroscience, 1990
Rats chronically implanted with intrathecal catheters received intrathecal injections (10 microliters followed by 10 microliters saline flush) of either saline (n = 5), somatostatin (100 micrograms, n = 10), the somatostatin analog BIM 23003 (100 micrograms, n = 5), the somatostatin analog SMS 201-995 (100 micrograms, n = 5), the substance P analog [D ...
D M, Gaumann, T S, Grabow, T L, Yaksh, S J, Casey, M, Rodriguez   +4 more
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