Results 11 to 20 of about 43,726 (267)

Somatostatin receptor expression in parathyroid neoplasms

Endocrine Connections, 2019
Introduction: Parathyroid carcinoma represents a rare cause of primary hyperparathyroidism. Distinguishing carcinoma from the benign tumors underlying primary hyperparathyroidism remains challenging.
Sara Storvall, Helena Leijon, Eeva Ryhänen, Johanna Louhimo, Caj Haglund, Camilla Schalin-Jäntti, Johanna Arola   +6 more
doaj   +1 more source

Role of Somatostatin Receptor in Pancreatic Neuroendocrine Tumor Development, Diagnosis, and Therapy

Frontiers in Endocrinology, 2021
Pancreatic neuroendocrine tumors (pNETs) are rare and part of the diverse family of neuroendocrine neoplasms (NENs). Somatostatin receptors (SSTRs), which are widely expressed in NENs, are G-protein coupled receptors that can be activated by ...
Yuheng Hu, Yuheng Hu, Yuheng Hu, Yuheng Hu, Zeng Ye, Zeng Ye, Zeng Ye, Zeng Ye, Fei Wang, Fei Wang, Fei Wang, Fei Wang, Yi Qin, Yi Qin, Yi Qin, Yi Qin, Xiaowu Xu, Xiaowu Xu, Xiaowu Xu, Xiaowu Xu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Xianjun Yu, Shunrong Ji, Shunrong Ji, Shunrong Ji, Shunrong Ji   +27 more
doaj   +1 more source

Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice

Molecular Metabolism, 2021
Objective: Maintenance of glucose homeostasis requires the precise regulation of hormone secretion from the endocrine pancreas. Free fatty acid receptor 4 (FFAR4/GPR120) is a G protein-coupled receptor whose activation in islets of Langerhans promotes ...
Marine L. Croze, Marcus F. Flisher, Arthur Guillaume, Caroline Tremblay, Glyn M. Noguchi, Sabrina Granziera, Kevin Vivot, Vincent C. Castillo, Scott A. Campbell, Julien Ghislain, Mark O. Huising, Vincent Poitout   +11 more
doaj   +1 more source

Somatostatin receptors

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2003
In 1972, Brazeau et al. isolated somatostatin (somatotropin release-inhibiting factor, SRIF), a cyclic polypeptide with two biologically active isoforms (SRIF-14 and SRIF-28). This event prompted the successful quest for SRIF receptors. Then, nearly a quarter of a century later, it was announced that a neuropeptide, to be named cortistatin (CST), had ...
Møller, Lars Neisig, Stidsen, Carsten Enggaard, Hartmann, Bolette, Holst, Jens Juul   +3 more
openaire   +2 more sources

Carboxyl-terminal receptor domains control the differential dephosphorylation of somatostatin receptors by protein phosphatase 1 isoforms. [PDF]

PLoS ONE, 2014
We have recently identified protein phosphatase 1β (PP1β) as G protein-coupled receptor (GPCR) phosphatase for the sst2 somatostatin receptor using siRNA knockdown screening.
Andreas Lehmann, Andrea Kliewer, Jan Carlo Märtens, Falko Nagel, Stefan Schulz   +4 more
doaj   +1 more source

Evaluation of 99mTc-HYNIC-TOC and 131I-MIBG imaging in diagnosis of pheochromocytoma and paraganglioma [PDF]

Jichu yixue yu linchuang
Objective To evaluate 99mTc-HYNIC-TOC somatostatin receptor and 131I-MIBG imaging in clinical diag- nostic of pheochromocytoma and paraganglioma (PPGL).
WANG Yu, TONG Anli, ZHOU Yue, ZHANG Wenqian, CUI Yunying, JING Hongli , LI Yuxiu
doaj   +1 more source

Expanding the Indication for Novel Theranostic 177Lu-Dotatate Peptide Receptor Radionuclide Therapy: Proof-of-Concept of PRRT in Merkel Cell Cancer

Case Reports in Oncology, 2019
The field of theranostics is a new nuclear medicine tool being utilized in the treatment of different types of cancers. It couples receptor-specific based imaging predicting and guiding response to receptor-specific based radionuclide therapies.
Pashtoon M. Kasi, Akash Sharma, Manoj K. Jain   +2 more
doaj   +1 more source

Peptide receptor radionuclide therapy (PRRT) in radioiodine-refractory thyroid cancer: A case report of significant response to lu177 DOTA-TATE treatment

Archives of Endocrinology and Metabolism, 2022
SUMMARY A 59-year-old woman with follicular thyroid carcinoma underwent total thyroidectomy followed by radioiodine treatment. Following treatment, the whole-body scan did not show any abnormal radioiodine uptake. However, during the follow-up, the serum
Saeideh Ataei-Nakhaei, Kamran Aryana, Sayyed Mostafa Mostafavi, Hadis Mohammadzadeh Kosari, Mohammad Esmatinia, Atena Aghaee   +5 more
doaj   +1 more source

The somatostatinergic system in the mammalian cochlea

BMC Neuroscience, 2011
Background Little is known about expression and function of the somatostatinergic system in the mammalian cochlea. We have previously shown that somatostatin administration may have a protective effect on gentamicin-induced hair cell loss. In this study,
Kapfhammer Josef P, Brand Yves, Setz Cristian, Hanusek Claudia, Radojevic Vesna, Bodmer Daniel   +5 more
doaj   +1 more source

Pharmacological Characterization of Veldoreotide as a Somatostatin Receptor 4 Agonist

Life, 2021
Veldoreotide, a somatostatin analogue, binds to the somatostatin receptors (SSTR) 2, 4, and 5. The current aim was to assess its pharmacological activity as an SSTR4 agonist.
Pooja Dasgupta, Thomas Gűnther, Stefan Schulz   +2 more
doaj   +1 more source