Results 11 to 20 of about 2,397,304 (343)

Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes. [PDF]

Front Pharmacol, 2023
Glucose homeostasis is primarily maintained by pancreatic hormones, insulin and glucagon, with an emerging role for a third islet hormone, somatostatin, in regulating insulin and glucagon responses.
Hoffman EG, D'Souza NC, Liggins RT, Riddell MC.   +3 more
europepmc   +2 more sources

Comprehensive Assessment of Somatostatin Receptors in Various Neoplasms: A Systematic Review

Pharmaceutics, 2022
Somatostatin receptors (SSTR) are expressed in various neoplasms and can be targeted for both diagnostics as well as therapeutics. This systematic review aims to compile and discuss the prevalence of somatostatin receptor expression in various neoplasms.
Shista Priyadarshini, Derek B. Allison, Aman Chauhan   +2 more
doaj   +1 more source

Preclinical study of a new ¹⁷⁷Lu-labeled somatostatin receptor antagonist in HT-29 human colorectal cancer cells. [PDF]

Asia Oceania Journal of Nuclear Medicine and Biology, 2020
Objective(s): Somatostatin receptor-positive neuroendocrine tumors have been targeted using various peptide analogs radiolabeled with therapeutic radionuclides for years.
Hossein Behnammanesh, Mostafa Erfani, Maliheh Hajiramezanali, Safura Jokar, Parham Geramifar, Omid Sabzevari, Mohsen Amini, Seyed Mohammad Mazidi, Davood Beiki   +8 more
openalex   +3 more sources

Somatostatin Receptors and Analogs in Pheochromocytoma and Paraganglioma: Old Players in a New Precision Medicine World

Frontiers in Endocrinology, 2021
Neuroendocrine tumors overexpress somatostatin receptors, which serve as important and unique therapeutic targets for well-differentiated advanced disease.
Mayank Patel, Isabel Tena, Isabel Tena, Abhishek Jha, David Taieb, Karel Pacak   +5 more
doaj   +1 more source

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity

eLife, 2022
Somatostatin is a peptide hormone that regulates endocrine systems by binding to G-protein-coupled somatostatin receptors. Somatostatin receptor 2 (SSTR2) is a human somatostatin receptor and is highly implicated in hormone disorders, cancers, and ...
Yunseok Heo, Eojin Yoon, Ye-Eun Jeon, Ji-Hye Yun, Naito Ishimoto, Hyeonuk Woo, Sam-Yong Park, Ji-Joon Song, Weontae Lee   +8 more
doaj   +1 more source

Somatostatin receptor expression in multiple hemangiomas. [PDF]

Discov Oncol
Background Although hemangiomas frequently occur in the skin, mucosa, liver, and brain, they are rarely observed in the abdominal cavity or retroperitoneum.
Liu B, Li S, Xu Y, Huang X, Guo X, Wang H, Jiang S.   +6 more
europepmc   +2 more sources

A transplantable phosphorylation probe for direct assessment of G protein-coupled receptor activation. [PDF]

PLoS ONE, 2012
The newly developed multireceptor somatostatin analogs pasireotide (SOM230), octreotide and somatoprim (DG3173) have primarily been characterized according to their binding profiles.
Andrea Kliewer, Anika Mann, Aline Petrich, Florian Pöll, Stefan Schulz   +4 more
doaj   +1 more source

Two Birds with One Stone: Skull Base Meningioma and Jugulotympanic Paragangliomas with Somatostatin Receptor Positron Emission Tomography

Diagnostics, 2021
We describe the case of a 74-year-old female patient previously treated with radiation therapy for a meningioma of the skull base and with surgery for a right tympanic paraganglioma.
Giorgio Treglia, Mariana Raditchkova, Luca Giovanella, Jean-Jacques Stelmes, Davide G. Bosetti, Francesco Martucci   +5 more
doaj   +1 more source

The role of somatostatin receptor scintigraphy in the diagnosis and follow-up of the pancreatic neuroendocrine neoplasms [PDF]

Nuclear Technology and Radiation Protection, 2020
The aim of investigation was to assess the role of somatostatin receptor scintigraphy in diagnosis and follow-up of pancreatic neuroendocrine neoplasms.
Šaponjski Jelena M., Šobić-Šaranović Dragana P., Macut Đuro P., Isailović Tatjana V., Bogosavljević Nikola M., Jovanović Darko D., Artiko Vera M.   +6 more
doaj   +1 more source

Somatostatin receptors in congenital hyperinsulinism: Biology to bedside

Frontiers in Endocrinology, 2022
Congenital hyperinsulinism (CHI), although a rare disease, is an important cause of severe hypoglycemia in early infancy and childhood, causing preventable morbidity and mortality.
Mirjam E. van Albada, Klaus Mohnike, Mark J. Dunne, Indi Banerjee, Stephen F. Betz   +4 more
doaj   +1 more source