Results 191 to 200 of about 39,903 (228)
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The somatostatin receptor family
Life Sciences, 1995The diverse biological effects of somatostatin (SST) are mediated through a family of G protein coupled receptors of which 5 members have been recently identified by molecular cloning. This review focuses on the molecular biology, pharmacology, expression, and function of these receptors with particular emphasis on the human (h) homologs.
Y C, Patel +5 more
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Somatostatin and somatostatin receptors in the diagnosis and treatment of gliomas
Journal of Neuro-Oncology, 1997Somatostatin analogues are in clinical use for the diagnosis and treatment of several oncological indications, namely pituitary adenomas and endocrine gastrointestinal tumors. In addition for a variety of malignancies their potential value is being studied.
K, Lamszus, W, Meyerhof, M, Westphal
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[Somatostatin and somatostatin receptors in the prostate].
Minerva endocrinologica, 2001Somatostatin (st) exerts a role in the control of prostate growth and function acting both at hypothalamus-hypophysis level and at glandular level. St analogues have been used to control prostate cancer (CaP) in clinical trials, with contradictory results.
SINISI, Antonio Agostino +2 more
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Molecular biology of somatostatin receptors
Trends in Neurosciences, 1993The neuropeptide somatostatin (SRIF) has diverse physiological actions in the brain and endocrine organs. A family of SRIF receptors has recently been cloned that may mediate the distinct biological effects of SRIF. These receptors have a high degree of amino acid sequence similarity among themselves, but their sequences are different from any other ...
G I, Bell, T, Reisine
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[Immunity and somatostatin receptors].
Minerva endocrinologica, 2001The presence of at least three different types of somatostatin receptors in the thymus has been demonstrated using molecular biology techniques or radioimmunological methods. In view of the chemotactical activity shown by somatostatin in other lymphopoietic regions like bone marrow, it was hypothesised that this neuropeptide might play a role in ...
PELUSO G, MANSI, Luigi
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The Somatostatin Receptor In The GI Tract
Annual Review of Physiology, 1992Since its isolation from the hypothalamus in 1973 (10), somatostatin has been shown to occur not only in the brain, but also in almost all peripheral tissues. This ubiquitous distribution and short half-life of somatostatin in the blood suggest that this peptide could play a local regulatory role and implies the involvement of receptors distributed ...
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Somatostatin and somatostatin receptors in the immune system: a review.
European cytokine network, 2000Communication and reciprocal regulation between the nervous, endocrine and immune systems are essential for the stability of the organism. Among others, cytokines, hormones and neuropeptides have been identified as signalling molecules mediating the communication between the three systems.
ten Bokum, AMC (Annemieke) +2 more
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2002
Abstract Somatostatin (Somatotropin-release inhibiting factor, SRIF) produced by neuronal, neuroendocrine, inflammatory and immune cells as well as tumours, produces its many (patho)physiological functions through activation of specific cell membrane receptors.
Patrick P A Humphrey, Daniel Hoyer
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Abstract Somatostatin (Somatotropin-release inhibiting factor, SRIF) produced by neuronal, neuroendocrine, inflammatory and immune cells as well as tumours, produces its many (patho)physiological functions through activation of specific cell membrane receptors.
Patrick P A Humphrey, Daniel Hoyer
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