Cordycepin improves hyperactivation and acrosome reaction through adenosine receptors during human sperm capacitation in vitro [PDF]
Reproductive Biology and EndocrinologyBackground Sperm capacitation is a prerequisite for natural or in vitro fertilization. After capacitation, sperm become hyperactivated and undergo an acrosome reaction, which helps them penetrate the oocyte.
Lijun Shan +8 more
doaj +2 more sources
Quantitative phosphoproteomics analyses reveal the regulatory mechanisms related to frozen-thawed sperm capacitation and acrosome reaction in yak (Bos grunniens) [PDF]
Frontiers in Physiology, 2022 Mammalian spermatozoa are not mature after ejaculation and must undergo additional functional and structural changes within female reproductive tracts to achieve subsequent fertilization, including both capacitation and acrosome reaction (AR), which are ...
Renzheng Zhang +9 more
doaj +2 more sources
New insights into posttranslational modifications of proteins during bull sperm capacitation [PDF]
Cell Communication and Signaling, 2023 Background Due to the unique nature of spermatozoa, which are transcriptionally and translationally silent, the regulation of capacitation is based on the formation of posttranslational modifications of proteins (PTMs).
Agnieszka Mostek-Majewska +3 more
doaj +2 more sources
Capacitation increases glucose consumption in murine sperm
Molecular Reproduction and Development, 2020 Mammalian sperm acquire fertilization capacity in the female reproductive tract in a process known as capacitation. During capacitation, sperm change their motility pattern (i.e., hyperactivation) and become competent to undergo the acrosome reaction. We
Ana Romarowski +2 more
exaly +2 more sources
Bottom-up approach to deciphering the targets of the ubiquitin-proteasome system in porcine sperm capacitation [PDF]
Scientific ReportsCapacitation is an essential post-testicular maturation event endowing spermatozoa with fertilizing capacity within the female reproductive tract, significant for fertility, reproductive health, and contraception.
Michal Zigo +7 more
doaj +2 more sources
Sperm capacitation in bulls, rams, bucks, and boars: molecular mechanisms and species-specific differences [PDF]
Frontiers in Veterinary ScienceCapacitation is the process by which sperm undergoes physical, biochemical, and molecular changes to acquire the ability to fertilize an oocyte.
Abdulkadir Kaya +5 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2021 To become fully competent to fertilize an egg, mammalian sperm undergo a series of functional changes within the female tract, known as capacitation, that require an adequate supply and management of energy.
María Milagros Giaccagli +6 more
doaj +2 more sources
Citrate Promotes Nitric Oxide Production during Human Sperm Capacitation [PDF]
AntioxidantsSperm capacitation is a complex process essential for the spermatozoon to recognize and fertilize the oocyte. For capacitation to occur, human spermatozoa require low levels of reactive oxygen species (ROS), increased protein tyrosine phosphorylation ...
Diego Loggia, Cristian O’Flaherty
doaj +2 more sources
Levels of Protein CoAlation Regulate Redox Signaling Events of Human Sperm Capacitation [PDF]
AntioxidantsInfertility is a global health problem, with male factors contributing to nearly half of all cases. Up to 30% of male infertility is classified as idiopathic, in part because routine semen analysis does not assess sperm fertilizing competence ...
Chika Onochie +3 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2023 Mammalian sperm require sufficient energy to support motility and capacitation for successful fertilization. Previous studies cataloging the changes to metabolism in sperm explored ejaculated human sperm or dormant mouse sperm surgically extracted from ...
Melanie Balbach +2 more
exaly +3 more sources