Advanced Paternal Age Impacts Common Loci in the Sperm and Placenta DNA Methylomes
ABSTRACT Background Epidemiological studies have reported an association between advanced paternal age at conception and an increased risk of neurodevelopmental disorders in offspring, such as autism spectrum disorder. Evidence suggests that DNA methylation alterations in spermatozoa of older men may be transmitted to the feto‐placental unit and ...
Julia Barnwell +12 more
wiley +1 more source
hnRNPU Safeguards Oocyte Development and Female Fertility via Regulation of Alternative Splicing
Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is essential for oocyte development and female fertility. Oocyte‐specific deletion of Hnrnpu leads to follicular arrest, impaired meiotic maturation, mitochondrial dysfunction, and infertility.
Jinmei Li +8 more
wiley +1 more source
The timing of de novo DNA methylation in male germ cells during human testicular development is yet unsolved. Apart from that, the stability of established imprinting patterns in vitro is controversially discussed.
Daniel Langenstroth-Röwer +6 more
doaj +1 more source
HAGE, a cancer/testis antigen expressed at the protein level in a variety of cancers [PDF]
The search for novel tumour antigens that are either uniquely expressed or over-expressed in a wide variety of tumours is still ongoing. Because of their expression in a broad spectrum of cancers and limited expression in normal tissues, cancer/testis ...
Badoual, C +6 more
core
Several therapeutic effects have been reported for Peganum harmala and Piper longum. These plants contain flavonoids that probably can affect reproductive endocrine system and reduce fertility.
Namdar Yousefvand +2 more
doaj
Deletion of Mgat2 in spermatogonia blocks spermatogenesis
Identifying factors required for spermatogenesis is important for understanding mechanisms of male fertility. Inactivation of either the Mgat1 or Man2a2 gene leads to a block in spermatogenesis causing infertility in male mice. MGAT1 GlcNAc-transferase initiates complex N-glycan synthesis and MAN2A2 mannosidase generates the substrate for MGAT2 GlcNAc ...
Mohd Shamoon Asmat +5 more
openaire +3 more sources
Ultrastructure of the reproductive system of the black swamp snake (\u3ci\u3eSeminatrix pygaea\u3c/i\u3e). Part III. The sexual segment of the male kidney. [PDF]
In mature male snakes and lizards, a distal portion of the nephron is hypertrophied in relation to its appearance in females and immature males. This sexual segment of the male kidney apparently provides seminal fluid that is mixed with sperm and ...
Sever, David M.
core +1 more source
Histologi Testis Mencit (Mus Musculus L.) Muda dan Tua yang Diberi Ekstrak Lada Hitam (Piper Nigrum L.) [PDF]
Lada hitam (Piper nigrum L.) dipercaya oleh masyarakat memiliki banyak khasiat. Selain membuat penggunanya tetap sehat, lada hitam juga diduga memiliki kandungan antioksidan yang mampu menangkap radikal bebas sebagai salah satu faktor pemacu penuaan ...
Kanedi, M. (M) +3 more
core
Donor Preparation for Germ Cell Transplantation in Giant Gouramy: the Viability of Spermatogonia Isolated From Giant Gouramy Cold Preserved Testis [PDF]
The recent study has been conducted to develop testicular germ cell (TGC) transplantation as a tool for preservation and propagation of male germ-plasm from endangered fish species.
Alimuddin, A. (Alimuddin) +3 more
core
Enrichment of porcine spermatogonia by differential culture [PDF]
E, Behboodi +5 more
openaire +2 more sources

