BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: Spermatogenesis is sustained by the homeostasis of self-renewal and differentiation of undifferentiated spermatogonia throughout life, which is regulated by transcriptional and posttranscriptional mechanisms.
Yonglin Peng, Yunqiang Wu, Congxia Hu
exaly +4 more sources
BRCA1 preserves genome integrity during the formation of undifferentiated spermatogonia [PDF]
EMBO ReportsUndifferentiated spermatogonia, which form shortly after birth, consist of spermatogonial stem cells and progenitor spermatogonia that maintain homeostasis.
Longfei Ma, Chunsheng Han, Lin-Yu Lu
exaly +3 more sources
Culture of Kenyan Goat (Capra hircus) Undifferentiated Spermatogonia in Feeder-Free Conditions [PDF]
Frontiers in Veterinary Science, 2022 The undifferentiated spermatogonial population in mammalian testes contains a spermatogonial stem cell (SSC) population that can regenerate continual spermatogenesis following transplantation.
Nakami Wilkister Nabulindo +9 more
doaj +2 more sources
Vaccinia-Related Kinase 1 Is Required for the Maintenance of Undifferentiated Spermatogonia in Mouse Male Germ Cells [PDF]
PLoS ONE, 2010 Vaccinia-related kinase 1 (VRK1) is a crucial protein kinase for mitotic regulation. VRK1 is known to play a role in germ cell development, and its deficiency results in sterility.
Yoon Ha Choi, Wanil Kim, Hua Ling
exaly +2 more sources
Stem Cell Research, 2022 In adult testis, the cell mobility is essential for spermatogonia differentiation and is suspected to regulate spermatogonial stem cell fate. Netrin-1 controls cell migration and/or survival according to the cellular context. Its involvement in some self-
Vilma Barroca +2 more
exaly +3 more sources
Methamphetamine-induced inhibition of Mettl21c in undifferentiated spermatogonia impairs male fertility in mice [PDF]
Asian Journal of AndrologyChronic methamphetamine (Meth) exposure has been recognized as a critical risk factor for male reproductive dysfunction, yet its mechanistic underpinnings remain elusive.
Xue-Heng Zhao +4 more
doaj +2 more sources
Persistence of undifferentiated spermatogonia in aged Japanese Black cattle [PDF]
Animal Science Journal, 2021 Kenshiro Hara
exaly +2 more sources
A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche [PDF]
Advanced ScienceChildhood cancer treatments often impair male fertility due to gonadotoxic effects. While in vitro culture of prepubertal testis tissue offers a potential solution to preserve fertility, producing sufficient sperm remains a major barrier. To address this,
Yu Xia +14 more
doaj +2 more sources
Phospholipase D Family Member 6 Is a Surface Marker for Enrichment of Undifferentiated Spermatogonia in Prepubertal Boars [PDF]
Stem Cells and Development, 2018 Yi Zheng, Wenxian Zeng
exaly +2 more sources
Core binding factor subunit β plays diverse and essential roles in the male germline
Frontiers in Cell and Developmental Biology, 2023 Much of the foundation for lifelong spermatogenesis is established prior to puberty, and disruptions during this developmental window negatively impact fertility long into adulthood.
Mustika Rahmawati +7 more
doaj +1 more source