Results 1 to 10 of about 213 (102)
BMI1 fine-tunes gene repression and activation to safeguard undifferentiated spermatogonia fate
Frontiers in Cell and Developmental Biology, 2023 Introduction: Spermatogenesis is sustained by the homeostasis of self-renewal and differentiation of undifferentiated spermatogonia throughout life, which is regulated by transcriptional and posttranscriptional mechanisms.
Xiao-Dong Zhao, Jielin Sun, Yunqiang Wu
exaly +5 more sources
BRCA1 preserves genome integrity during the formation of undifferentiated spermatogonia
EMBO ReportsUndifferentiated spermatogonia, which form shortly after birth, consist of spermatogonial stem cells and progenitor spermatogonia that maintain homeostasis.
Peng Li, Yidan Liu, Lin-Yu Lu
exaly +5 more sources
Stem Cell Research, 2022 In adult testis, the cell mobility is essential for spermatogonia differentiation and is suspected to regulate spermatogonial stem cell fate. Netrin-1 controls cell migration and/or survival according to the cellular context. Its involvement in some self-
Mathieu Coureuil +2 more
exaly +6 more sources
Persistence of undifferentiated spermatogonia in aged Japanese Black cattle [PDF]
Animal Science Journal, 2021 Abstract Aging is a major risk factor for spermatogenesis deterioration. However, the influence of age on spermatogenic stem cells and their progenitors in bulls is largely unknown. Here, we report age‐related changes in undifferentiated and differentiating spermatogonia in Japanese Black cattle with nearly constant sperm output, by ...
Kenshiro Hara, Kentaro Tanemura
exaly +3 more sources
Vaccinia-Related Kinase 1 Is Required for the Maintenance of Undifferentiated Spermatogonia in Mouse Male Germ Cells [PDF]
PLoS ONE, 2010 Vaccinia-related kinase 1 (VRK1) is a crucial protein kinase for mitotic regulation. VRK1 is known to play a role in germ cell development, and its deficiency results in sterility.
Matthew Wook Chang +2 more
exaly +2 more sources
Undifferentiated primate spermatogonia and their endocrine control [PDF]
Trends in Endocrinology and Metabolism, 2010 The biology of spermatogonial stem cells is currently an area of intensive research and contemporary studies in primates are emerging. Quantitative regulation of sperm output by the primate testis seems to be exerted primarily on the transition from undifferentiated to differentiating spermatogonia.
Tony M Plant
exaly +3 more sources
The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse [PDF]
BMC Developmental Biology, 2009 AbstractBackgroundLife-long production of spermatozoa depends on spermatogonial stem cells. Spermatogonial stem cells exist among the most primitive population of germ cells – undifferentiated spermatogonia. Transplantation experiments have demonstrated the functional heterogeneity of undifferentiated spermatogonia.
Xin Wu, Ke Zheng, Klaus H. Kaestner
exaly +3 more sources
Culture of Kenyan Goat (Capra hircus) Undifferentiated Spermatogonia in Feeder-Free Conditions
Frontiers in Veterinary Science, 2022 The undifferentiated spermatogonial population in mammalian testes contains a spermatogonial stem cell (SSC) population that can regenerate continual spermatogenesis following transplantation.
Nakami Wilkister Nabulindo +9 more
doaj +4 more sources
Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population
Developmental Biology, 2008 Nanos gene encodes for zinc-finger protein with putative RNA-binding activity which shows an evolutionary conserved function in germ cell development. In the mouse, three Nanos homologs have been identified: Nanos1, Nanos2 and Nanos3. The Nanos3 ortholog is expressed in both male and female gonads of early embryo and, after birth, it is found only in ...
Maria Paola Paronetto +2 more
exaly +5 more sources
Differential expression of c-kit in mouse undifferentiated and differentiating type A spermatogonia. [PDF]
Endocrinology, 1999 The proto-oncogene c-kit is encoded at the white-spotting locus and in the mouse mutations at this locus affect the precursor cells of melanocytes, hematopoietic cells, and germ cells. c-kit is expressed in type A spermatogonia, but whether or not c-kit is present both in undifferentiated and differentiating type A spermatogonia or only in the latter ...
Ans van Pelt +2 more
exaly +5 more sources