Results 11 to 20 of about 4,581 (187)

Long-Term Propagation of Porcine Undifferentiated Spermatogonia. [PDF]

Stem Cells Dev, 2017
Spermatogonial stem cells (SSCs) provide the foundation for spermatogenesis and fertility throughout the adult life of a male. Genetic manipulations of SSCs combined with germ cell transplantation present a novel approach for gene therapy and production of genetically modified animals.
Zhang P, Chen X, Zheng Y, Zhu J, Qin Y, Lv Y, Zeng W.   +6 more
europepmc   +6 more sources

Doxorubicin and vincristine affect undifferentiated rat spermatogonia [PDF]

Reproduction, 2017
Abstract Anticancer drugs, such as alkylating agents, can affect male fertility by targeting the DNA of proliferative spermatogonial stem cells (SSC). Therefore, to reduce such side effects, other chemotherapeutics are used. However, less is known about their potential genotoxicity on SSC.
Beaud, Hermance, van Pelt, Ans M., Delbès, Géraldine   +2 more
openaire   +5 more sources

Regulation of Cell Fate Decision of Undifferentiated Spermatogonia by GDNF

Science, 2000
The molecular control of self-renewal and differentiation of stem cells has remained enigmatic. Transgenic loss-of-function and overexpression models now show that the dosage of glial cell line–derived neurotrophic factor (GDNF), produced by Sertoli cells, regulates cell fate decisions of undifferentiated spermatogonial cells that include ...
Meng, X., Lindahl, M., Hyvönen, M. E., Parvinen, M., de rooij, D. G., Hess, M. W., Raatikainen-Ahokas, A., Sainio, K., Rauvala, H., Lakso, M., Pichel, J. G., Westphal, H., Saarma, M., Sariola, H.   +13 more
openaire   +5 more sources

Characterization of undifferentiated spermatogonia and the spermatogonial niche in the lambari fish Astyanax altiparanae

Theriogenology, 2017
Undifferentiated type A spermatogonia are the foundation of fish spermatogenesis. This cell population includes the spermatogonial stem cell population, which is able to either self-renew or differentiate into cells that will generate the male gamete - the spermatozoa. Spermatogonia stem cells are located in a specific region of the testes known as the
de Paiva Camargo, Marília, Cassel, Mônica, Oliveira de Jesus, Lázaro Wender, Nóbrega, Rafael Henrique, Borella, Maria Inês   +4 more
openaire   +4 more sources

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia [PDF]

Nature Communications, 2019
Sustained sperm production is dependent on activity of undifferentiated spermatogonia. Here, the authors demonstrate an essential role for RNA helicase DDX5 in maintenance of spermatogonia in adults through control of gene transcription plus RNA ...
Julien M. D. Legrand, Ai-Leen Chan, Hue M. La, Fernando J. Rossello, Minna-Liisa Änkö, Frances V. Fuller-Pace, Robin M. Hobbs   +6 more
doaj   +2 more sources

Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis

Developmental Biology, 2005
Sox3, a member of the high mobility group (HMG) family of transcription factors, is expressed in neural progenitor cells and in the gonads. Targeted deletion of Sox3 in mice causes abnormal development of the diencephalon and Rathke's pouch, the progenitor of the anterior pituitary gland.
Raverot, Gerald, Weiss, Jeffrey, Park, Susan Y., Hurley, Lisa, Jameson, J. Larry   +4 more
openaire   +3 more sources

Isolation of Undifferentiated Spermatogonia from Adult and Developing Mouse Testes. [PDF]

Methods Mol Biol, 2023
In the mammalian testis, the mitotic complements of spermatogenic cells are spermatogonia, including spermatogonial stem cells (SSCs) which form the basis of life-long spermatogenesis and male fertility. Thus, investigating spermatogonia and subdivisions thereof is essential to increase our understanding of male germline development and infertility ...
van Melis V, Roa-de la Cruz L, Hermann BP.   +2 more
europepmc   +3 more sources

MRE11 is essential for the long-term viability of undifferentiated spermatogonia. [PDF]

Cell Prolif
AbstractIn the meiotic prophase, programmed SPO11‐linked DNA double‐strand breaks (DSBs) are repaired by homologous recombination (HR). The MRE11‐RAD50‐NBS1 (MRN) complex is essential for initiating DNA end resection, the first step of HR. However, residual DNA end resection still occurs in Nbs1 knockout (KO) spermatocytes for unknown reasons. Here, we
Tang Z, Liang Z, Zhang B, Xu X, Li P, Li L, Lu LY, Liu Y.   +7 more
europepmc   +3 more sources

The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia. [PDF]

Development, 2016
Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout adulthood through balanced self-renewal and differentiation, yet the regulatory logic of these fate decisions is poorly understood. The transcription factors Sal-like 4 (SALL4) and zinc finger and BTB domain containing 16 (ZBTB16, aka: PLZF) are known to be required for normal SSC ...
Lovelace DL, Gao Z, Mutoji K, Song YC, Ruan J, Hermann BP.   +5 more
europepmc   +3 more sources

Effects of neonatal hypothyroidism on testicular development and undifferentiated spermatogonia in prepubertal rats. [PDF]

Andrology
Abstract Background Thyroid hormones play a key role in testicular development, particularly in the regulation of Sertoli cell proliferation and differentiation. While congenital hypothyroidism is common and treatable, the effects of thyroid hormone insufficiency on early testicular development
Matsumoto D, Mizuno K, Nishio H, Kamisawa H, Sakata T, Kato T, Nakane A, Kurokawa S, Maruyama T, Hayashi Y, Yasui T.   +10 more
europepmc   +4 more sources