Results 11 to 20 of about 213 (102)
Core binding factor subunit β plays diverse and essential roles in the male germline
Frontiers in Cell and Developmental Biology, 2023 Much of the foundation for lifelong spermatogenesis is established prior to puberty, and disruptions during this developmental window negatively impact fertility long into adulthood.
Mustika Rahmawati +7 more
doaj +1 more source
Asian Journal of AndrologyChronic methamphetamine (Meth) exposure has been recognized as a critical risk factor for male reproductive dysfunction, yet its mechanistic underpinnings remain elusive.
Xue-Heng Zhao +4 more
doaj +3 more sources
Doxorubicin and vincristine affect undifferentiated rat spermatogonia [PDF]
Reproduction, 2017 Abstract Anticancer drugs, such as alkylating agents, can affect male fertility by targeting the DNA of proliferative spermatogonial stem cells (SSC). Therefore, to reduce such side effects, other chemotherapeutics are used. However, less is known about their potential genotoxicity on SSC.
Beaud, Hermance +2 more
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Long-Term Propagation of Porcine Undifferentiated Spermatogonia [PDF]
Stem Cells and Development, 2017 Spermatogonial stem cells (SSCs) provide the foundation for spermatogenesis and fertility throughout the adult life of a male. Genetic manipulations of SSCs combined with germ cell transplantation present a novel approach for gene therapy and production of genetically modified animals.
Zhang, Pengfei +6 more
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The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia [PDF]
Development, 2016 Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout adulthood through balanced self-renewal and differentiation, yet the regulatory logic of these fate decisions is poorly understood. The transcription factors Sal-like 4 (SALL4) and zinc finger and BTB domain containing 16 (ZBTB16, aka: PLZF) are known to be required for normal SSC ...
Dawn L. Lovelace +5 more
openaire +2 more sources
Cell & Bioscience, 2023 Background Spermatogonial stem cells (SSCs) provide a foundation for robust and continual spermatogenesis in mammals. SSCs self-renew to maintain a functional stem cell pool and differentiate to supply committed progenitors.
Rong-Ge Yan +5 more
doaj +1 more source
Animals, 2022 Vimentin is a type of intermediate filament (IF) and one of the first filaments expressed in spermatogenesis. Vimentin plays numerous roles, consisting of the determination of cell shape, differentiation, cell motility, the maintenance of cell junctions,
Amirreza Niazi Tabar +3 more
doaj +1 more source
SALL4 expression in gonocytes and spermatogonial clones of postnatal mouse testes. [PDF]
PLoS ONE, 2013 The spermatogenic lineage is established after birth when gonocytes migrate to the basement membrane of seminiferous tubules and give rise to spermatogonial stem cells (SSC). In adults, SSCs reside within the population of undifferentiated spermatogonia (
Kathrin Gassei, Kyle E Orwig
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PLoS Genetics, 2021 Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. Aging leads to the decline in stem cell function and increased risk of paternal age-related genetic diseases.
Jinyue Liao +6 more
doaj +1 more source
eLife, 2020 Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with ...
Maria M Mikedis +7 more
doaj +1 more source