Results 31 to 40 of about 213 (102)
The niche-derived glial cell line-derived neurotrophic factor (GDNF) induces migration of mouse spermatogonial stem/progenitor cells. [PDF]
PLoS ONE, 2013 In mammals, the biological activity of the stem/progenitor compartment sustains production of mature gametes through spermatogenesis. Spermatogonial stem cells and their progeny belong to the class of undifferentiated spermatogonia, a germ cell ...
Lisa Dovere +8 more
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Beyond stem cells: Commitment of progenitor cells to meiosis
Stem Cell Research, 2018 The first step in established spermatogenesis is the production of progenitor cells by the stem cell population. The progenitor cells (undifferentiated A spermatogonia) expand in number via the formation of syncytial chains by mitosis.
Michael D. Griswold, Cathryn Hogarth
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The essential roles of M ps 1 in spermatogenesis and fertility in mice
Cell Death and Disease, 2021 Monopolar spindle 1 (MPS1), which plays a critical role in somatic mitosis, has also been revealed to be essential for meiosis I in oocytes. Spermatogenesis is an important process involving successive mitosis and meiosis, but the function of MPS1 in ...
Qiang Fang +8 more
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Andrology, 2023 AbstractBackgroundAcetaminophen and ibuprofen are widely administered to babies due to their presumed safety as over‐the‐counter drugs. However, no reports exist on the effects of cyclooxygenase inhibitors on undifferentiated spermatogonia and spermatogonial stem cells.
Amy Tran‐Guzman +2 more
openaire +2 more sources
Nature Communications, 2019 Sustained sperm production is dependent on activity of undifferentiated spermatogonia. Here, the authors demonstrate an essential role for RNA helicase DDX5 in maintenance of spermatogonia in adults through control of gene transcription plus RNA ...
Julien M. D. Legrand +6 more
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Cell Death and Disease, 2021 Spermatogonia transit-amplifying (TA) divisions are crucial for the differentiation of germline stem cell daughters. However, the underlying mechanism is largely unknown.
Jun Yu +9 more
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Conservation of spermatogonial stem cell marker expression in undifferentiated felid spermatogonia [PDF]
Theriogenology, 2016 Spermatogonial stem cells (SSCs) are distinct in their ability to self-renew, transmit genetic information, and persist throughout the life of an individual. These characteristics make SSCs a useful tool for addressing diverse challenges such as efficient transgenic production in nonrodent, biomedical animal models, or preservation of the male genome ...
Lindsey M, Vansandt +5 more
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Recent Update on Retinoic Acid-Driven Initiation of Spermatogonial Differentiation
Frontiers in Cell and Developmental Biology, 2022 Germ cells (Gc) propagate the genetic information to subsequent generations. Diploid (2n) Gc get transformed to specialized haploid (n) gametes by mitotic and meiotic divisions in adult gonads.
Indrashis Bhattacharya +5 more
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Mitochondrial fusion is required for spermatogonial differentiation and meiosis
eLife, 2019 Differentiating cells tailor their metabolism to fulfill their specialized functions. We examined whether mitochondrial fusion is important for metabolic tailoring during spermatogenesis.
Grigor Varuzhanyan +6 more
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Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation in vitro
Nature Communications, 2021 Retinoic acid is necessary but not sufficient to induce meiosis. Here, the authors use primary mouse undifferentiated spermatogonia culture to show that nutrient restriction, an inducer of yeast meiosis, combined with retinoic acid induces meiotic gene ...
Xiaoyu Zhang +2 more
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