Results 31 to 40 of about 4,581 (187)

Spermatogonial Gene Networks Selectively Couple to Glutathione and Pentose Phosphate Metabolism but Not Cysteine Biosynthesis

iScience, 2021
Summary: In adult males, spermatogonia maintain lifelong spermatozoa production for oocyte fertilization. To understand spermatogonial metabolism we compared gene profiles in rat spermatogonia to publicly available mouse, monkey, and human spermatogonial
David Prokai, Ashutosh Pudasaini, Mohammed Kanchwala, Andrew T. Moehlman, Alexandrea E. Waits, Karen M. Chapman, Jaideep Chaudhary, Jesus Acevedo, Patrick Keller, Xing Chao, Bruce R. Carr, F. Kent Hamra   +11 more
doaj   +1 more source

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes

Stem Cell Reports, 2017
Sustained spermatogenesis in adult males and fertility recovery following germ cell depletion are dependent on undifferentiated spermatogonia. We previously demonstrated a key role for the transcription factor SALL4 in spermatogonial differentiation ...
Ai-Leen Chan, Hue M. La, Julien M.D. Legrand, Juho-Antti Mäkelä, Michael Eichenlaub, Mia De Seram, Mirana Ramialison, Robin M. Hobbs   +7 more
doaj   +1 more source

Purification of GFRα1+ and GFRα1– Spermatogonial Stem Cells Reveals a Niche-Dependent Mechanism for Fate Determination

Stem Cell Reports, 2018
Summary: Undifferentiated spermatogonia comprise a pool of stem cells and progenitor cells that show heterogeneous expression of markers, including the cell surface receptor GFRα1.
Alina Garbuzov, Matthew F. Pech, Kazuteru Hasegawa, Meena Sukhwani, Ruixuan J. Zhang, Kyle E. Orwig, Steven E. Artandi   +6 more
doaj   +1 more source

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

eLife, 2022
Alternative splicing expands the transcriptome and proteome complexity and plays essential roles in tissue development and human diseases. However, how alternative splicing regulates spermatogenesis remains largely unknown.
Wenbo Liu, Xukun Lu, Zheng-Hui Zhao, Ruibao SU, Qian-Nan Li Li, Yue Xue, Zheng Gao, Si-Min Sun Sun, Wen-Long Lei, Lei Li, Geng An, Hanyan Liu, Zhiming Han, Ying-Chun Ouyang, Yi Hou, Zhen-Bo Wang, Qing-Yuan Sun, Jianqiao Liu   +17 more
doaj   +1 more source

UTF1, a putative marker for spermatogonial stem cells in stallions. [PDF]

PLoS ONE, 2014
Spermatogonial stem cells (SSCs) continuously undergo self-renewal and differentiation to sustain spermatogenesis throughout adulthood in males. In stallions, SSCs may be used for the production of progeny from geldings after cryopreservation and therapy
Heejun Jung, Janet F Roser, Minjung Yoon
doaj   +1 more source

Identification of dynamic undifferentiated cell states within the male germline

Nature Communications, 2018
Sustained spermatogenesis depends on stem cell activity which is contained within a population of undifferentiated spermatogonia. Here, the authors identify a new population of undifferentiated spermatogonia in adult testis that expresses the ...
Hue M. La, Juho-Antti Mäkelä, Ai-Leen Chan, Fernando J. Rossello, Christian M. Nefzger, Julien M. D. Legrand, Mia De Seram, Jose M. Polo, Robin M. Hobbs   +8 more
doaj   +1 more source

The niche-derived glial cell line-derived neurotrophic factor (GDNF) induces migration of mouse spermatogonial stem/progenitor cells. [PDF]

PLoS ONE, 2013
In mammals, the biological activity of the stem/progenitor compartment sustains production of mature gametes through spermatogenesis. Spermatogonial stem cells and their progeny belong to the class of undifferentiated spermatogonia, a germ cell ...
Lisa Dovere, Stefania Fera, Margherita Grasso, Dante Lamberti, Cesare Gargioli, Barbara Muciaccia, Anna Maria Lustri, Mario Stefanini, Elena Vicini   +8 more
doaj   +1 more source

Beyond stem cells: Commitment of progenitor cells to meiosis

Stem Cell Research, 2018
The first step in established spermatogenesis is the production of progenitor cells by the stem cell population. The progenitor cells (undifferentiated A spermatogonia) expand in number via the formation of syncytial chains by mitosis.
Michael D. Griswold, Cathryn Hogarth
doaj   +1 more source

The essential roles of M ps 1 in spermatogenesis and fertility in mice

Cell Death and Disease, 2021
Monopolar spindle 1 (MPS1), which plays a critical role in somatic mitosis, has also been revealed to be essential for meiosis I in oocytes. Spermatogenesis is an important process involving successive mitosis and meiosis, but the function of MPS1 in ...
Qiang Fang, Xue-Lin Chen, Lei Zhang, Ya-Bin Li, Tian-Zeng Sun, Chen-Xin Yang, Jian-Feng Chang, Xiao-Mei Yang, Feng Sun   +8 more
doaj   +1 more source

Conservation of spermatogonial stem cell marker expression in undifferentiated felid spermatogonia [PDF]

Theriogenology, 2016
Spermatogonial stem cells (SSCs) are distinct in their ability to self-renew, transmit genetic information, and persist throughout the life of an individual. These characteristics make SSCs a useful tool for addressing diverse challenges such as efficient transgenic production in nonrodent, biomedical animal models, or preservation of the male genome ...
Lindsey M, Vansandt, Janelle L, Livesay, Melissa Joy, Dickson, Lei, Li, Budhan S, Pukazhenthi, Carol L, Keefer   +5 more
openaire   +2 more sources