Results 41 to 50 of about 213 (102)

Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis

Developmental Biology, 2005
Sox3, a member of the high mobility group (HMG) family of transcription factors, is expressed in neural progenitor cells and in the gonads. Targeted deletion of Sox3 in mice causes abnormal development of the diencephalon and Rathke's pouch, the progenitor of the anterior pituitary gland.
Raverot, Gerald, Weiss, Jeffrey, Park, Susan Y., Hurley, Lisa, Jameson, J. Larry   +4 more
openaire   +2 more sources

Spermatogonial stem cell niche and spermatogonial stem cell transplantation in zebrafish. [PDF]

PLoS ONE, 2010
BACKGROUND: Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, and reside within a specific microenvironment in the testes called "niche" which regulates stem cell properties, such as, self-renewal, pluripotency, quiescence and their
Rafael Henrique Nóbrega, Caaj Douwe Greebe, Henk van de Kant, Jan Bogerd, Luiz Renato de França, Rüdiger W Schulz   +5 more
doaj   +1 more source

Conditions for Long-Term Culture of Cattle Undifferentiated Spermatogonia

Biology of Reproduction, 2016
Continual and robust spermatogenesis relies on the actions of an undifferentiated spermatogonial population that contains stem cells. A remarkable feature of spermatogonial stem cells (SSCs) is the capacity to regenerate spermatogenesis following isolation from a donor testis and transplantation into a permissive recipient testis.
Melissa J, Oatley, Amy V, Kaucher, Qi-En, Yang, Muhammad Salman, Waqas, Jon M, Oatley   +4 more
openaire   +2 more sources

THY1 is a conserved marker of undifferentiated spermatogonia in the pre-pubertal bull testis [PDF]

Reproduction, 2010
Abstract The undifferentiated spermatogonial population consists of stem and progenitor germ cells which function to provide the foundation for spermatogenesis. The stem cell component, termed spermatogonial stem cells (SSCs), is capable of self-renewal and differentiation.
Suzanne C, Reding, Aaron L, Stepnoski, Elizabeth W, Cloninger, Jon M, Oatley   +3 more
openaire   +2 more sources

FSH regulates RA signaling to commit spermatogonia into differentiation pathway and meiosis

Reproductive Biology and Endocrinology, 2021
Background Spermatogenesis is a complex process that is controlled by interactions between germ cells and somatic cells. The commitment of undifferentiated spermatogonia to differentiating spermatogonia and normal spermatogenesis requires the action of ...
Maryam Khanehzad, Roya Abbaszadeh, Marzieh Holakuyee, Mohammad Hossein Modarressi, Seyed Mehdi Nourashrafeddin   +4 more
doaj   +1 more source

Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells

Cells, 2021
Spermatogonia are stem and progenitor cells responsible for maintaining mammalian spermatogenesis. Preserving the balance between self-renewal of spermatogonial stem cells (SSCs) and differentiation is critical for spermatogenesis and fertility ...
Whitney F. Alpaugh, Anna L. Voigt, Rkia Dardari, Lin Su, Iman Al Khatib, Wisoo Shin, Taylor M. Goldsmith, Krysta M. Coyle, Lin A. Tang, Timothy E. Shutt, Claudia Klein, Jeff Biernaskie, Ina Dobrinski   +12 more
doaj   +1 more source

Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development

Epigenetics & Chromatin, 2022
Testis development and sustained germ cell production in adults rely on the establishment and maintenance of spermatogonia stem cells and their proper differentiation into spermatocytes.
Rodrigo O. de Castro, Agustin Carbajal, Luciana Previato de Almeida, Victor Goitea, Courtney T. Griffin, Roberto J. Pezza   +5 more
doaj   +1 more source

Sertoli cell and spermatogonial development in pigs

Journal of Animal Science and Biotechnology, 2022
Background Spermatogenesis is an intricate developmental process during which undifferentiated spermatogonia, containing spermatogonial stem cells (SSCs), undergo self-renewal and differentiation to generate eventually mature spermatozoa. Spermatogenesis
Yi Zheng, Qiang Gao, Tianjiao Li, Ruifang Liu, Zechao Cheng, Ming Guo, Jinhong Xiao, De Wu, Wenxian Zeng   +8 more
doaj   +1 more source

Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals

Stem Cells International, 2022
Spermatogonial stem cells (SSCs) are the germline stem cells that are essential for the maintenance of spermatogenesis in the testis. However, it has not been sufficiently understood in amphibians, reptiles, and fish because numerous studies have been ...
Hyuk Song, Hyun-Jung Park, Won-Young Lee, Kyung Hoon Lee   +3 more
doaj   +1 more source

Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice.

PLoS ONE, 2021
Spermatogenesis requires that a careful balance be maintained between the self-renewal of spermatogonial stem cells (SSCs) and their commitment to the developmental pathway through which they will differentiate into spermatozoa.
Alexandre Boyer, Xiangfan Zhang, Adrien Levasseur, Nour Abou Nader, Guillaume St-Jean, Makoto C Nagano, Derek Boerboom   +6 more
doaj   +1 more source