Results 61 to 70 of about 4,581 (187)

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

MicroRNAs 221 and 222 regulate the undifferentiated state in mammalian male germ cells [PDF]

, 2013
Continuity of cycling cell lineages relies on the activities of undifferentiated stem cell-containing subpopulations. Transition to a differentiating state must occur periodically in a fraction of the population to supply mature cells, coincident with ...
Racicot, Karen E, Kaucher, Amy V, Oatley, Melissa J, Oatley, Jon M, Yang, Qi-En   +4 more
core   +2 more sources

Models and Molecular Markers of Spermatogonial Stem Cells in Vertebrates: To Find Models in Nonmammals

Stem Cells International, 2022
Spermatogonial stem cells (SSCs) are the germline stem cells that are essential for the maintenance of spermatogenesis in the testis. However, it has not been sufficiently understood in amphibians, reptiles, and fish because numerous studies have been ...
Hyuk Song, Hyun-Jung Park, Won-Young Lee, Kyung Hoon Lee   +3 more
doaj   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Dmrt1 mutant undifferentiated spermatogonia can differentiate.

, 2016
IF of sectioned control (A-C, G-I, M-O) and conditional mutant (D-F, J-L, P-R) seminiferous tubules 10 and 15 days post-tamoxifen (DPT) detecting tdTomato (red) and three stage-specific germ cell markers (green). DAPI (blue) stains DNA.
Jon Oatley (397323), David Zarkower (67393), Vivian J. Bardwell (271153), Teng Zhang (457128)   +3 more
core   +1 more source

Testis‐Enriched F‐Box Protein FBXO39 Is Important for Spermiogenesis and Male Fertility in Mice

Andrology, EarlyView.
ABSTRACT Background The SCF (Skp–Cullin–F‐box) complex is a major class of E3 ubiquitin ligases. F‐box proteins constitute the SCF complex and play a critical role in recognizing substrates for ubiquitination. In mice, several F‐box proteins, including FBXO36 and FBXO39, are predominantly expressed in testes.
Yuki Kaneda, Haruhiko Miyata, Masahito Ikawa   +2 more
wiley   +1 more source

Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice.

PLoS ONE, 2021
Spermatogenesis requires that a careful balance be maintained between the self-renewal of spermatogonial stem cells (SSCs) and their commitment to the developmental pathway through which they will differentiate into spermatozoa.
Alexandre Boyer, Xiangfan Zhang, Adrien Levasseur, Nour Abou Nader, Guillaume St-Jean, Makoto C Nagano, Derek Boerboom   +6 more
doaj   +1 more source

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

Andrology, EarlyView.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik, Jessica M. Snyder, Haley A. Martin, John K. Amory   +3 more
wiley   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, EarlyView.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

Ablation of RXR blocks spermatogonia are at the undifferentiated stage.

, 2015
In situ hybridization with anti-sense probes for Gfra1, Zbtb16, Kit and Stra8 on histological sections of 12 month-old control (A-D), Rxra;b;gSpg–/–(E-H) and Rara;b;gSpg–/–(I-L) testes. Undifferentiated spermatogonia expressing Gfra1 and Zbtb16 are found
Aurore Gely-Pernot (802378), Manuel Mark (107795), Norbert B. Ghyselinck (107799), Marius Teletin (802380), Muriel Klopfenstein (107793), Mathilde Raverdeau (802379), Betty Féret (802381), Christine Dennefeld (802382), Nadège Vernet (589562), Irwin Davidson (518811), Gérard Benoit (265726)   +10 more
core   +1 more source