Results 51 to 60 of about 213 (102)

Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitions

BMC Genomics
Background Spermatogonial stem cells (SSCs) are the foundation cells for continual spermatogenesis and germline regeneration in mammals. SSC activities reside in the undifferentiated spermatogonial population, and currently, the molecular identities of ...
Shuang Li, Rong-Ge Yan, Xue Gao, Zhen He, Shi-Xin Wu, Yu-Jun Wang, Yi-Wen Zhang, Hai-Ping Tao, Xiao-Na Zhang, Gong-Xue Jia, Qi-En Yang   +10 more
doaj   +1 more source

Single-cell transcriptome analysis and in vitro differentiation of testicular cells reveal novel insights into male sterility of the interspecific hybrid cattle-yak

BMC Genomics, 2023
Background Interspecific hybridization plays vital roles in enriching animal diversity, while male hybrid sterility (MHS) of the offspring commonly suffered from spermatogenic arrest constitutes the postzygotic reproductive isolation.
TserangDonko Mipam, Xuemei Chen, Wangsheng Zhao, Peng Zhang, Zhixin Chai, Binglin Yue, Hui Luo, Jikun Wang, Haibo Wang, Zhijuan Wu, Jiabo Wang, Mingxiu Wang, Hui Wang, Ming Zhang, Hongying Wang, Kemin Jing, Jincheng Zhong, Xin Cai   +17 more
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Characterization of undifferentiated spermatogonia and the spermatogonial niche in the lambari fish Astyanax altiparanae

Theriogenology, 2017
Undifferentiated type A spermatogonia are the foundation of fish spermatogenesis. This cell population includes the spermatogonial stem cell population, which is able to either self-renew or differentiate into cells that will generate the male gamete - the spermatozoa. Spermatogonia stem cells are located in a specific region of the testes known as the
de Paiva Camargo, Marília, Cassel, Mônica, Oliveira de Jesus, Lázaro Wender, Nóbrega, Rafael Henrique, Borella, Maria Inês   +4 more
openaire   +3 more sources

The Role of Plzf in Spermatogonial Stem Cell Maintenance and Differentiation: Mapping the Transcriptional Dynamics and Key Interactions

Cells
Spermatogonial stem cells (SSCs) sustain and modulate spermatogenesis through intricate signaling pathways and transcription factors. Promyelocytic leukemia zinc-finger (Plzf, also known as Zbtb16) has been identified as a critical transcription factor ...
Nima Ghasemi, Hossein Azizi, Seyedeh-Kiana Razavi-Amoli, Thomas Skutella   +3 more
doaj   +1 more source

Isolation of THY1+ Undifferentiated Spermatogonia from Mouse Postnatal Testes Using Magnetic-activated Cell Sorting (MACS)

Bio-Protocol, 2016
In mammals, homeostasis of many tissues rely on a subpopulation of cells, referred to as stem cells, to sustain an appropriate number of undifferentiated and differentiated cells.
Hung-Fu Liao, Joyce Kuo, Hsien-Hen Lin, Shau-Ping Lin   +3 more
doaj   +1 more source

MRE11 is essential for the long‐term viability of undifferentiated spermatogonia

Cell Proliferation
AbstractIn the meiotic prophase, programmed SPO11‐linked DNA double‐strand breaks (DSBs) are repaired by homologous recombination (HR). The MRE11‐RAD50‐NBS1 (MRN) complex is essential for initiating DNA end resection, the first step of HR. However, residual DNA end resection still occurs in Nbs1 knockout (KO) spermatocytes for unknown reasons. Here, we
Zhenghui Tang, Zhongyang Liang, Bin Zhang, Xiaohui Xu, Peng Li, Lejun Li, Lin‐Yu Lu, Yidan Liu   +7 more
openaire   +2 more sources

RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner

Communications Biology
Post-transcriptional regulation mediated by RNA binding proteins is crucial for male germline development. Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), an RNA binding protein, is specifically expressed in human and mouse male gonads and
Jiaqiang Luo, Chao Yang, Shuai Xu, Zhiyong Ji, Yuxiang Zhang, Haowei Bai, Zhiwen Deng, Jiayi Liang, Yuhua Huang, Erlei Zhi, Ruhui Tian, Peng Li, Fujun Zhao, Zhi Zhou, Zheng Li, Chencheng Yao   +15 more
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Puma and Trail/Dr5 pathways control radiation-induced apoptosis in distinct populations of testicular progenitors.

PLoS ONE, 2010
Spermatogonia- stem cells and progenitors of adult spermatogenesis- are killed through a p53-regulated apoptotic process after gamma-irradiation but the death effectors are still poorly characterized.
Mathieu Coureuil, Nicolas Ugolin, Marie Tavernier, Sylvie Chevillard, Vilma Barroca, Pierre Fouchet, Isabelle Allemand   +6 more
doaj   +1 more source

Low-dose ionizing irradiation triggers apoptosis of undifferentiated spermatogonia in vivo and in vitro

Translational Andrology and Urology, 2019
The present study aimed to investigate the mechanism of low-dose ionizing radiation (IR) induced apoptosis of undifferentiated spermatogonia in vivo and in vitro.Following 50 mGy IR, testicular tissues were collected from the adult DBA/2 mice at 1, 2 and 24 h; mice in the control group received pseudo-irradiation.
Lixin, Qi, Jiaxuan, Li, Wei, Le, Jinfu, Zhang   +3 more
openaire   +3 more sources

Sox9 downregulation in non-obstructive azoospermia by UTF1 and mediator role of POU5F1

BMC Research Notes
Background Spermatogenesis is the process of producing mature sperm from Spermatogonial stem cells (SSCs) and this process requires a complex cooperation of different types of somatic and germ cells.
Mehdi Mehdinezhad Roshan, Hossein Azizi, Mohammadreza Ashtari Majelan, Amirreza Niazi Tabar   +3 more
doaj   +1 more source