Results 21 to 30 of about 4,581 (187)

Low-dose ionizing irradiation triggers apoptosis of undifferentiated spermatogonia in vivo and in vitro. [PDF]

Transl Androl Urol, 2019
The present study aimed to investigate the mechanism of low-dose ionizing radiation (IR) induced apoptosis of undifferentiated spermatogonia in vivo and in vitro.Following 50 mGy IR, testicular tissues were collected from the adult DBA/2 mice at 1, 2 and 24 h; mice in the control group received pseudo-irradiation.
Qi L, Li J, Le W, Zhang J.
europepmc   +4 more sources

Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression

Cell & Bioscience, 2023
Background Spermatogonial stem cells (SSCs) provide a foundation for robust and continual spermatogenesis in mammals. SSCs self-renew to maintain a functional stem cell pool and differentiate to supply committed progenitors.
Rong-Ge Yan, Zhen He, Fei-Chen Wang, Shuang Li, Qin-Bang Shang, Qi-En Yang   +5 more
doaj   +1 more source

Testicular Localization and Potential Function of Vimentin Positive Cells during Spermatogonial Differentiation Stages

Animals, 2022
Vimentin is a type of intermediate filament (IF) and one of the first filaments expressed in spermatogenesis. Vimentin plays numerous roles, consisting of the determination of cell shape, differentiation, cell motility, the maintenance of cell junctions,
Amirreza Niazi Tabar, Hossein Azizi, Danial Hashemi Karoii, Thomas Skutella   +3 more
doaj   +1 more source

SALL4 expression in gonocytes and spermatogonial clones of postnatal mouse testes. [PDF]

PLoS ONE, 2013
The spermatogenic lineage is established after birth when gonocytes migrate to the basement membrane of seminiferous tubules and give rise to spermatogonial stem cells (SSC). In adults, SSCs reside within the population of undifferentiated spermatogonia (
Kathrin Gassei, Kyle E Orwig
doaj   +1 more source

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation.

PLoS Genetics, 2021
Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. Aging leads to the decline in stem cell function and increased risk of paternal age-related genetic diseases.
Jinyue Liao, Hoi Ching Suen, Alfred Chun Shui Luk, Lele Yang, Annie Wing Tung Lee, Huayu Qi, Tin-Lap Lee   +6 more
doaj   +1 more source

DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

eLife, 2020
Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with ...
Maria M Mikedis, Yuting Fan, Peter K Nicholls, Tsutomu Endo, Emily K Jackson, Sarah A Cobb, Dirk G de Rooij, David C Page   +7 more
doaj   +1 more source

SETDB1 Regulates Porcine Spermatogonial Adhesion and Proliferation through Modulating MMP3/10 Transcription

Cells, 2022
The transition from gonocytes into spermatogonia takes place during the homing process. A subpopulation of undifferentiated spermatogonia in niche then shifts to spermatogonial stem cells (SSCs), accompanied by the self-renewal ability to maintain life ...
Ruifang Liu, Zidong Liu, Ming Guo, Wenxian Zeng, Yi Zheng   +4 more
doaj   +1 more source

The Dnmt3L ADD Domain Controls Cytosine Methylation Establishment during Spermatogenesis [PDF]

, 2015
A critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation. The catalytically inactive adaptor Dnmt3L is essential to ensuring this occurs correctly, but the mechanism by which it functions is unclear.
Robert J. Schmitz, Chad E. Niederhuth, Ooi, Steen KT, Stathopoulou, A, Richard G. Jenner, Steen K.T. Ooi, de Rooij, Dirk G, Tuna, Salih, Vlachogiannis, Georgios, Niederhuth, CE, Viiri, Keijo, Niederhuth, Chad E, Schmitz, RJ, Jenner, Richard G., Jenner, Richard G,, Vlachogiannis, G, Keijo Viiri, Tuna, S, Ooi, SK, Stathopoulou, Athanasia, Jenner, RG, Ooi, Steen K.T., de Rooij, DG, Dirk G. de Rooij, Schmitz, Robert J, de Rooij, Dirk G., Athanasia Stathopoulou, Salih Tuna, Niederhuth, Chad E., Schmitz, Robert J., Viiri, K, Ooi, Steen K. T., Georgios Vlachogiannis   +32 more
core   +1 more source

A scRNA-seq Approach to Identifying Changes in Spermatogonial Stem Cell Gene Expression Following in vitro Culture

Frontiers in Cell and Developmental Biology, 2022
Spermatogonial stem cell (SSC) function is essential for male fertility, and these cells hold potential therapeutic value spanning from human infertility treatments to wildlife conservation.
Camila Salum De Oliveira, Brett Nixon, Brett Nixon, Tessa Lord, Tessa Lord   +4 more
doaj   +1 more source

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

Advanced Science, 2022
Spermatogonial stem cells regenerate and maintain spermatogenesis throughout life, making testis a good model for studying stem cell biology. The effects of chemotherapy on fertility have been well‐documented previously.
Laura Thirouard, Hélène Holota, Mélusine Monrose, Manon Garcia, Angélique de Haze, Christelle Damon‐Soubeyrand, Yoan Renaud, Jean‐Paul Saru, Alessia Perino, Kristina Schoonjans, Claude Beaudoin, David H. Volle   +11 more
doaj   +1 more source