Results 21 to 30 of about 213 (102)

SETDB1 Regulates Porcine Spermatogonial Adhesion and Proliferation through Modulating MMP3/10 Transcription

Cells, 2022
The transition from gonocytes into spermatogonia takes place during the homing process. A subpopulation of undifferentiated spermatogonia in niche then shifts to spermatogonial stem cells (SSCs), accompanied by the self-renewal ability to maintain life ...
Ruifang Liu, Zidong Liu, Ming Guo, Wenxian Zeng, Yi Zheng   +4 more
doaj   +1 more source

Feedback Regulation of the Proliferation of the Undifferentiated Spermatogonia In the Chinese Hamster By the Differentiating Spermatogonia

Cell Proliferation, 1985
AbstractIn the seminiferous epithelium the differentiating spermatogonia proliferate following a very strict synchronous pattern, and undergo the S phase during parts of particular epithelial stages. the undifferentiated spermatogonia do not divide synchronously and display maximum proliferative activity in stages XI‐III.
de rooij, D. G., Lok, D., Weenk, D.
openaire   +3 more sources

A scRNA-seq Approach to Identifying Changes in Spermatogonial Stem Cell Gene Expression Following in vitro Culture

Frontiers in Cell and Developmental Biology, 2022
Spermatogonial stem cell (SSC) function is essential for male fertility, and these cells hold potential therapeutic value spanning from human infertility treatments to wildlife conservation.
Camila Salum De Oliveira, Brett Nixon, Brett Nixon, Tessa Lord, Tessa Lord   +4 more
doaj   +1 more source

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

Advanced Science, 2022
Spermatogonial stem cells regenerate and maintain spermatogenesis throughout life, making testis a good model for studying stem cell biology. The effects of chemotherapy on fertility have been well‐documented previously.
Laura Thirouard, Hélène Holota, Mélusine Monrose, Manon Garcia, Angélique de Haze, Christelle Damon‐Soubeyrand, Yoan Renaud, Jean‐Paul Saru, Alessia Perino, Kristina Schoonjans, Claude Beaudoin, David H. Volle   +11 more
doaj   +1 more source

Spermatogonial Gene Networks Selectively Couple to Glutathione and Pentose Phosphate Metabolism but Not Cysteine Biosynthesis

iScience, 2021
Summary: In adult males, spermatogonia maintain lifelong spermatozoa production for oocyte fertilization. To understand spermatogonial metabolism we compared gene profiles in rat spermatogonia to publicly available mouse, monkey, and human spermatogonial
David Prokai, Ashutosh Pudasaini, Mohammed Kanchwala, Andrew T. Moehlman, Alexandrea E. Waits, Karen M. Chapman, Jaideep Chaudhary, Jesus Acevedo, Patrick Keller, Xing Chao, Bruce R. Carr, F. Kent Hamra   +11 more
doaj   +1 more source

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes

Stem Cell Reports, 2017
Sustained spermatogenesis in adult males and fertility recovery following germ cell depletion are dependent on undifferentiated spermatogonia. We previously demonstrated a key role for the transcription factor SALL4 in spermatogonial differentiation ...
Ai-Leen Chan, Hue M. La, Julien M.D. Legrand, Juho-Antti Mäkelä, Michael Eichenlaub, Mia De Seram, Mirana Ramialison, Robin M. Hobbs   +7 more
doaj   +1 more source

Purification of GFRα1+ and GFRα1– Spermatogonial Stem Cells Reveals a Niche-Dependent Mechanism for Fate Determination

Stem Cell Reports, 2018
Summary: Undifferentiated spermatogonia comprise a pool of stem cells and progenitor cells that show heterogeneous expression of markers, including the cell surface receptor GFRα1.
Alina Garbuzov, Matthew F. Pech, Kazuteru Hasegawa, Meena Sukhwani, Ruixuan J. Zhang, Kyle E. Orwig, Steven E. Artandi   +6 more
doaj   +1 more source

SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing

eLife, 2022
Alternative splicing expands the transcriptome and proteome complexity and plays essential roles in tissue development and human diseases. However, how alternative splicing regulates spermatogenesis remains largely unknown.
Wenbo Liu, Xukun Lu, Zheng-Hui Zhao, Ruibao SU, Qian-Nan Li Li, Yue Xue, Zheng Gao, Si-Min Sun Sun, Wen-Long Lei, Lei Li, Geng An, Hanyan Liu, Zhiming Han, Ying-Chun Ouyang, Yi Hou, Zhen-Bo Wang, Qing-Yuan Sun, Jianqiao Liu   +17 more
doaj   +1 more source

UTF1, a putative marker for spermatogonial stem cells in stallions. [PDF]

PLoS ONE, 2014
Spermatogonial stem cells (SSCs) continuously undergo self-renewal and differentiation to sustain spermatogenesis throughout adulthood in males. In stallions, SSCs may be used for the production of progeny from geldings after cryopreservation and therapy
Heejun Jung, Janet F Roser, Minjung Yoon
doaj   +1 more source

Identification of dynamic undifferentiated cell states within the male germline

Nature Communications, 2018
Sustained spermatogenesis depends on stem cell activity which is contained within a population of undifferentiated spermatogonia. Here, the authors identify a new population of undifferentiated spermatogonia in adult testis that expresses the ...
Hue M. La, Juho-Antti Mäkelä, Ai-Leen Chan, Fernando J. Rossello, Christian M. Nefzger, Julien M. D. Legrand, Mia De Seram, Jose M. Polo, Robin M. Hobbs   +8 more
doaj   +1 more source