Results 101 to 110 of about 77,896 (237)
British Journal of Haematology, EarlyView.We show how the loss of activity of the translation initiation factor EIF5A2—either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post‐translational modification—induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.
Eva Crespo‐García +5 more
wiley +1 more source
The FEBS Journal, EarlyView.Human SART3 has two RRM domains to engage with U6 snRNA for spliceosome recycling. This study reports solution structures of SART3 RRM domains and investigates the interaction between RRM and U6 snRNA. SART3 binds to the asymmetric bulge of U6 snRNA as a dimer via conserved positively charged surfaces.
Iktae Kim +8 more
wiley +1 more source
598 The polyamines spermidine and spermine are essential regulators of epidermal differentiation and cell migration during wound healing [PDF]
, 2022 Hooi Been Lim +3 more
openalex +1 more source
New Phytologist, EarlyView.Summary With the intensification of unpredictable flooding events because of global warming, there is a need to understand how root cells perceive and respond to oxygen deprivation. The use of high‐throughput single‐nuclei RNA‐sequencing (snRNA‐Seq) allows the examination of gene expression profiles in discrete cell types.
Robert D. Hill +5 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Low temperature triggers Ca2+ signalling and reprogramming of gene expression and metabolism in plants. However, how the Ca2+ signal is transduced to the downstream metabolic pathways remains unknown. The involvement of a cold‐induced calmodulin‐like protein, MfCML50, from Medicago falcata in regulation of cold tolerance was examined in the ...
Bohao Geng +6 more
wiley +1 more source
Oxidative Stress Associated with Chilling Injury in Immature Fruit: Postharvest Technological and Biotechnological Solutions [PDF]
, 2017 Immature, vegetable-like fruits are produced by crops of great economic importance, including cucumbers, zucchini, eggplants and bell peppers, among others. Because of their high respiration rates, associated with high rates of dehydration and metabolism,
Carvajal Moreno, Fátima +5 more
core +1 more source
Metabolomic systems biology of trypanosomes [PDF]
, 2010 Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental ...
BARBARA M. BAKKER +4 more
core +5 more sources
Plant Biotechnology Journal, EarlyView.ABSTRACT Soil salinization threatens the yield and quality of wheat. Roots are critical for the salt stress response, yet their cell‐type‐specific mechanisms remain unclear. We conducted the first single‐nucleus RNA sequencing analysis of wheat root tips from salt‐sensitive (CS) and ‐tolerant (DK) varieties under salt stress, profiling 188 270 high ...
Lin Du +10 more
wiley +1 more source
EFFECT OF POLYAMINE STRUCTURE ON GROWTH STIMULATION AND SPERMINE AND SPERMIDINE CONTENT OF LACTIC ACID BACTERIA [PDF]
, 1964 Beverly M. Guirard, Esmond E. Snell
openalex +1 more source
Reducing the Sinapine Levels of Camelina sativa Seeds Through Targeted Genome Editing of REF1
Plant Biotechnology Journal, EarlyView.ABSTRACT Sinapine (O‐sinapoyl choline) is the major phenolic metabolite typically found in the oil‐rich seeds of Brassicaceae such as Camelina sativa and Brassica napus. It imparts a bitter taste to the seeds as a defence mechanism against herbivores, but it also renders them less palatable to livestock.
Amélie A. Kelly +5 more
wiley +1 more source