Results 1 to 10 of about 1,019 (188)

Combination therapy with spesolimab and apremilast for refractory generalized pustular psoriasis: a case report [PDF]

Frontiers in Medicine
Generalized pustular psoriasis (GPP) is a rare, life-threatening neutrophilic dermatosis characterized by recurrent episodes of widespread sterile pustules, systemic inflammation, and potential multi-organ failure.
Yuwei Li, Zhenyu Li, Xinhong Hu, Tianyu Cao, Ling Liu   +4 more
doaj   +6 more sources

Analysis of Predefined Safety Events Across Spesolimab Trials in Dermatological and Non-Dermatological Conditions [PDF]

Dermatology and Therapy
Introduction Spesolimab, a selective, humanised monoclonal antibody targeting the interleukin-36 receptor, is approved for the treatment of generalised pustular psoriasis (GPP).
Kenneth B. Gordon, Yayoi Tada, Milan J. Anadkat, Siew Eng Choon, Boni Elewski, Jonathan N. Barker, Arash Mostaghimi, Kilian Eyerich, Ming Tang, Thomas Haeufel, Christian Thoma, Diamant Thaçi   +11 more
doaj   +3 more sources

Spesolimab Treatment in GPP: Impact of IL-36RN Mutations and Concomitant Plaque Psoriasis [PDF]

Clinical, Cosmetic and Investigational Dermatology
Wei Li,1– 3,* Jingyao Liang,2,* Yuwu Luo,2 Shuting Chen,2 Manqi Xia,2 Hui Ye,2 Bin Yang,1,3 Quan Luo2 1Department of Dermatology, First Affiliated Hospital of Jinan University, Guangzhou, 510630, People’s Republic of China; 2Department of
Li W, Liang J, Luo Y, Chen S, Xia M, Ye H, Yang B, Luo Q   +7 more
doaj   +3 more sources

Case report: Successful treatment with spesolimab of acrodermatitis continua of Hallopeau in an older patient without IL36RN mutations [PDF]

Frontiers in Immunology
BackgroundAcrodermatitis continua of Hallopeau (ACH) is a rare, sterile pustular psoriasis variant refractory to many conventional treatments. The eruption typically occurs after local trauma or infection; other etiologies include neural, inflammatory ...
Jianfeng Zheng, Yangfeng Ding, Yuling Shi, Xuemei Yi   +3 more
doaj   +3 more sources

Case Report: Spesolimab for pyoderma gangrenosum in an undifferentiated oligoarthritis patient receiving anti-IL-17 therapy [PDF]

Frontiers in Immunology
Pyoderma gangrenosum (PG) is a classic neutrophilic dermatosis often associated with inflammatory conditions, frequently leading to misdiagnosis and delayed treatment. Drug-induced and postoperative are two potential triggers of PG.
Weiwei Xin, Liyang Gu, Fang Du, Ting Li, Shuang Ye   +4 more
doaj   +3 more sources

Generalized Pustular Psoriasis During Early Pregnancy Successfully Treated with Spesolimab: A Case Report [PDF]

International Medical Case Reports Journal
Xinlong Chen, Degui Chang, Chenjian Tang Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of ChinaCorrespondence: Chenjian Tang, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s ...
Chen X, Chang D, Tang C
doaj   +3 more sources

Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights [PDF]

Frontiers in Immunology
A 62-year-old Chinese woman presented to the hospital for help with generalized pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH).
Xin-Yi Hou, Hai-Lu Xiao, Jing-Yu Wang, Jin Zhang, Bo Ren, Chu-chu Niu, Fei-Fei Liu, Bin Lu   +7 more
doaj   +3 more sources

Generalized Pustular Psoriasis with Cushing's Syndrome: A Case of Effective Spesolimab Treatment. [PDF]

Biologics
Generalized pustular psoriasis (GPP) is a rare neutrophilic skin disease characterized by persistent symptoms and sudden onset of painful, sterile pustules. These pustules may be accompanied by systemic inflammation and can be life-threatening in severe cases.
Peng G, Zhang Y, Zhang S, Li Y, Luo L, Luo J, Nie X, Zhang H, Liao C.   +8 more
europepmc   +4 more sources

Achieving Therapeutic Success with Spesolimab: Two Cases of Drug-Induced Generalized Pustular Psoriasis Initially Mimicking Acute Generalized Exanthematous Pustulosis [PDF]

Journal of Inflammation Research
Jianxia Chen,1,* Yuting Xia,2,3,* Faqiong Zhou,1 Juan Tao,2,3 Nuoya Zhou2,3 1Department of Dermatology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei, People’s Republic of China; 2Department of ...
Chen J, Xia Y, Zhou F, Tao J, Zhou N
doaj   +3 more sources

Successful treatment of acrodermatitis continua of Hallopeau coexisting with generalized pustular psoriasis with spesolimab: a case report [PDF]

Frontiers in Immunology
Generalized pustular psoriasis (GPP) is a rare chronic inflammatory pustular dermatosis that presents as painful erythema with sterile pustules on nonacral skin. No unified standard and guideline for the treatment of GPP has been established.
Pengfei Wen, Chuan Liu, Tingting Wang, Xian Jiang, Ping Wang, Sheng Wang   +5 more
doaj   +4 more sources