Results 31 to 40 of about 1,019 (188)

The efficacy and safety of spesolimab in patients with generalized pustular psoriasis flares: a systematic review and meta-analysis [PDF]

Frontiers in Medicine
BackgroundGeneralized pustular psoriasis (GPP) is a rare, auto-inflammatory skin disease characterized by unpredictable flares, often requiring hospitalization, and current therapies lack robust evidence.ObjectivesTo systematically evaluate the efficacy ...
Dhaii Alzahrani, Dhaii Alzahrani, Afnan Hasanain, Renad Alharthy, Renad Alharthy, Yara Aljefri, Yara Alghamdi, Yara Alghamdi, Yara Alghamdi, Renad Alshaikh, Renad Alshaikh, Almaha Alhijab, Faris Neazy, Faris Neazy, Abdulmajeed Alosaimi, Abdulmajeed Alosaimi, Badr Felemban, Badr Felemban, Reshale Johar, Reshale Johar, Reshale Johar, Roaa E. Morya, Roaa E. Morya, Roaa E. Morya   +23 more
doaj   +2 more sources

Intralesional Spesolimab: A Novel and Effective Approach for Palmoplantar Pustulosis Treatment - A Case Report. [PDF]

Int Med Case Rep J
Palmoplantar pustulosis (PPP) is a chronic condition characterized by the presence of sterile pustules on the palms and soles of the feet. As we all know, there is currently no gold standard for the treatment of this intractable disease.
Wang SN, Lu YZ, Zhao Y, Cao W, Zhang RL.
europepmc   +2 more sources

Successful treatment of generalized pustular psoriasis during pregnancy with secukinumab in a patient hypersensitive to spesolimab: a case report

Journal of Dermatological Treatment
Objective Generalized pustular psoriasis (GPP) is a rare autoinflammatory skin disease characterized by recurrent, widespread eruption of sterile pustules rich in neutrophils. In addition to skin manifestations, this condition may be accompanied by fever,
Shuang Zhang, Guoyao Peng, Yun Zhang, Liping Luo, You Li, Jiaxin Luo, Tao Yu, Hongwei Zhang, Xinyi Nie, Xia Li, Jie Xiang, Chengcheng Liao   +11 more
doaj   +2 more sources

Successful treatment of generalized pustular psoriasis with chronic hepatitis B using spesolimab: A case report. [PDF]

Medicine (Baltimore)
Rationale: Generalized pustular psoriasis (GPP) is a severe form of pustular psoriasis, which can endanger the patient life. However, the conventional treatment for GPP presents several limitations.
Ming R, Zhang L, Xiong X.
europepmc   +2 more sources

Early Real-Life Experience with Spesolimab in the Treatment of Generalized Pustular Psoriasis: A Case Series of Three Patients Treated in a Compassionate Use Program. [PDF]

Case Rep Dermatol
Introduction: Generalized pustular psoriasis (GPP) is a rare and potentially life-threatening form of psoriasis, characterized by widespread sterile pustules and systemic symptoms.
Rittig AH, Bertelsen T, Stave SDW, Iversen L.   +3 more
europepmc   +2 more sources

Sequential Treatment of Generalized Pustular Psoriasis Combined with Bullous Pemphigoid Using Spesolimab and Dupilumab: A Case Report and Literature Review. [PDF]

Case Rep Dermatol
Introduction: Generalized pustular psoriasis (GPP) and bullous pemphigoid (BP) are two distinct but occasionally coexisting inflammatory skin disorders. Their simultaneous presence presents diagnostic and therapeutic challenges.
Wang Y, Yang H, Zhang Z, Yu H, Wang L, Bai Y.   +5 more
europepmc   +2 more sources

Effective Spesolimab Treatment for Generalized Pustular Psoriasis Masquerading as Acute Generalized Exanthematous Pustulosis: A Case Report. [PDF]

Cureus
Generalized pustular psoriasis (GPP) is a rare and severe variant of psoriasis, often posing diagnostic challenges due to its clinical overlap with acute generalized exanthematous pustulosis (AGEP), a severe drug-induced hypersensitivity reaction ...
Iijima K, Akiyama Y, Mizukawa I, Hirabayashi M, Kuwano Y.   +4 more
europepmc   +2 more sources

Cross-spectrum efficacy of spesolimab in IL-36-mediated dermatoses: a ′case study

Journal of Dermatological Treatment
Background The nosological distinction between acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) has become increasingly unclear due to shared IL-36 pathway dysregulation.
RuoYan Tong, ChaoChao Chen, Ling Huang, ChangWen Ni   +3 more
doaj   +2 more sources

Exploring the Chronic Nature of Generalized Pustular Psoriasis [Podcast] [PDF]

Clinical, Cosmetic and Investigational Dermatology
Boni Elewski,1 Mark G Lebwohl2 1Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA; 2Icahn School of Medicine at Mount Sinai, New York, NY, USACorrespondence: Boni Elewski, Email belewski@uabmc.eduAbstract: Generalized ...
Elewski B, Lebwohl MG
doaj   +2 more sources

Successful Treatment of Pediatric Generalized Pustular Psoriasis (GPP) with Spesolimab: 5 Case Reports and Evaluations of Circulating IL-36 Levels [PDF]

Journal of Inflammation Research
Yunliu Chen,1,2,* Zhaoyang Wang,1,2,* Yuan Liang,1,2 Chunping Shen,1,2 Lei Jiao,1,2 Xin Xiang,1,2 Chaoyang Miao,1,2 Zigang Xu1,2 1Department of Dermatology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s ...
Chen Y, Wang Z, Liang Y, Shen C, Jiao L, Xiang X, Miao C, Xu Z   +7 more
doaj   +2 more sources