Results 51 to 60 of about 117,630 (212)

The Duo of Osteogenic and Angiogenic Differentiation in ADSC-Derived Spheroids

Frontiers in Cell and Developmental Biology, 2021
Bone formation during embryogenesis is driven by interacting osteogenesis and angiogenesis with parallel endothelial differentiation. Thence, all in vitro bioengineering techniques are aimed at pre-vascularization of osteogenic bioequivalents to provide ...
Anastasiya A. Gorkun, Anastasiya A. Gorkun, Daria P. Revokatova, Daria P. Revokatova, Irina M. Zurina, Irina M. Zurina, Denis A. Nikishin, Denis A. Nikishin, Polina Y. Bikmulina, Peter S. Timashev, Peter S. Timashev, Peter S. Timashev, Peter S. Timashev, Anastasiya I. Shpichka, Nastasia V. Kosheleva, Nastasia V. Kosheleva, Nastasia V. Kosheleva, Tamara D. Kolokoltsova, Irina N. Saburina   +18 more
doaj   +1 more source

Biomaterials-assisted spheroid engineering for regenerative therapy

BMB Reports, 2021
Cell-based therapy is a promising approach in the field of regenerative medicine. As cells are formed into spheroids, their survival, functions, and engraftment in the transplanted site are significantly improved compared to single cell transplantation ...
Na-Hyun Lee, Oyunchimeg Bayaraa, Zhou Zechu, Hye Sung Kim   +3 more
semanticscholar   +1 more source

Routine Optical Clearing of 3D-Cell Cultures: Simplicity Forward

Frontiers in Molecular Biosciences, 2020
Three-dimensional cell cultures, such as spheroids and organoids, serve as increasingly important models in fundamental and applied research and start to be used for drug screening purposes.
Elina Nürnberg, Elina Nürnberg, Mario Vitacolonna, Julia Klicks, Elena von Molitor, Tiziana Cesetti, Florian Keller, Roman Bruch, Torsten Ertongur-Fauth, Katja Riedel, Paul Scholz, Thorsten Lau, Richard Schneider, Julia Meier, Mathias Hafner, Rüdiger Rudolf   +15 more
doaj   +1 more source

Deep Learning for Predicting Spheroid Viability: Novel Convolutional Neural Network Model for Automating Quality Control for Three-Dimensional Bioprinting

Bioengineering
Spheroids serve as the building blocks for three-dimensional (3D) bioprinted tissue patches. When larger than 500 μm, the desired size for 3D bioprinting, they tend to have a hypoxic core with necrotic cells.
Zyva A. Sheikh, Oliver Clarke, Amatullah Mir, Narutoshi Hibino   +3 more
doaj   +1 more source

Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model

Nanomaterials, 2020
(1) In compliance with the 3Rs policy to reduce, refine and replace animal experiments, the development of advanced in vitro models is needed for nanotoxicity assessment. Cells cultivated in 3D resemble organ structures better than 2D cultures.
E. Elje, E. Mariussen, O. H. Moriones, N. Bastus, V. Puntes, Y. Kohl, M. Dusinska, E. Rundén-Pran   +7 more
semanticscholar   +1 more source

Multi-Cell Type Glioblastoma Tumor Spheroids for Evaluating Sub-Population-Specific Drug Response

Frontiers in Bioengineering and Biotechnology, 2020
Glioblastoma (GBM) is a lethal, incurable form of cancer in the brain. Even with maximally aggressive surgery and chemoradiotherapy, median patient survival is 14.5 months.
Hemamylammal Sivakumar, Hemamylammal Sivakumar, Hemamylammal Sivakumar, Mahesh Devarasetty, David E. Kram, David E. Kram, Roy E. Strowd, Roy E. Strowd, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal   +14 more
doaj   +1 more source

Transport of ultrasmall gold nanoparticles (2 nm) across the blood–brain barrier in a six-cell brain spheroid model

Scientific Reports, 2020
The blood–brain barrier (BBB) is an efficient barrier for molecules and drugs. Multicellular 3D spheroids display reproducible BBB features and functions.
V. Sokolova, Gehad A. Mekky, S. B. van der Meer, M. Seeds, A. Atala, M. Epple   +5 more
semanticscholar   +1 more source

Establishment of a 3D spheroid culture system to evaluate the responsiveness of uterine leiomyoma cells to female hormones

Reproductive Medicine and Biology
Purpose Uterine leiomyomas (ULMs) are classified into those with and without MED12 mutations (MED12m(+) and MED12m(−), respectively). This study was undertaken to establish a culture system to evaluate the effect of female hormones on the growth of ULM ...
Takahiro Sakai, Shun Sato, Tetsuro Tamehisa, Hitomi Takasaki, Takuya Kajimura, Isao Tamura, Norihiro Sugino   +6 more
doaj   +1 more source

mTOR Pathway Inhibition, Anticancer Activity and In Silico Calculations of Novel Hydrazone Derivatives in Two- and Three-Dimensional Cultured Type 1 Endometrial Cancer Cells

Pharmaceuticals
Background: Endometrial cancer remains a significant health concern, with type 1 endometrial cancer characterized by aberrant expression of estrogen-dependent and mTOR pathway proteins.
Muhammet Volkan Bulbul, Arif Mermer, Bircan Kolbasi, Fatih Kocabas, Semiha Mervenur Kalender, Kiymet Asli Kirectepe Aydin, Turan Demircan, İlknur Keskin   +7 more
doaj   +1 more source

Enhanced immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells in 3D culture

Frontiers in Veterinary Science
IntroductionMesenchymal stem cells (MSCs) have been introduced as a treatment for dogs owing to their immunomodulatory effects. In humans, 3D-cultured MSCs have recently been applied in treating various conditions, including myocardial infarction, liver ...
Eunbi Lee, Ga-Hyun Lim, Ga-Hyun Lim, Ju-Hyun An, Min-Ok Ryu, Kyoung-Won Seo, Hwa-Young Youn   +6 more
doaj   +1 more source