Results 51 to 60 of about 130,558 (351)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The impact of spheroid stars for Macho microlensing surveys of the Andromeda Galaxy

, 2003
The Andromeda Galaxy (M31) is an important test case for a number of microlensing surveys looking for massive compact halo objects (Machos). A long-standing theoretical prediction is that the high inclination of the M31 disk should induce an asymmetry in
Kerins, E.
core   +2 more sources

Measuring star formation in high-z massive galaxies: A mid-infrared to submillimeter study of the GOODS NICMOS Survey sample [PDF]

, 2011
We present measurements of the mean mid-infrared-to-submillimeter flux densities of massive (M\ast \approx 2 \times 10^11 Msun) galaxies at redshifts 1.7 < z < 2.9, obtained by stacking positions of known objects taken from the GOODS NICMOS Survey (GNS ...
A. E. Bauer, Balestra, Bezanson, Blain, Bluck, Bruzual, Buat, Buitrago, Bundy, C. B. Netterfield, C. J. Conselice, Calzetti, Cava, Chabrier, Chapin, Chapin, Chary, Conroy, Conselice, Conselice, D. Scott, D. V. Wiebe, Daddi, Daddi, Damjanov, Devlin, Dole, E. L. Chapin, E. Mentuch, E. Pascale, F. Buitrago, Fioc, Foucaud, Frayer, G. Marsden, Genzel, Griffin, Hinshaw, Hopkins, I. Trujillo, Johansson, Kennicutt, Kennicutt, Kriek, Kriek, Kriek, L. Moncelsi, Lutz, M. D. P. Truch, M. Halpern, M. J. Devlin, M. P. Viero, M. Rex, M. W. L. Smith, Magee, Magnelli, Maraston, Marsden, Mentuch, Moncelsi, Muzzin, Müller, Naab, Nguyen, Oser, Ott, P. G. Pérez-González, Papovich, Pascale, Pascale, Pascale, Patanchon, Peng, Piovan, Poglitsch, Popesso, Prescott, Pérez-González, Ravindranath, Rieke, Salpeter, Siringo, Sérsic, Truch, Trujillo, Trujillo, Trujillo, Trujillo, van Dokkum, Wang, Weiß, Wuyts, Yan   +92 more
core   +5 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The merger history of massive spheroids since z~1 is size independent [PDF]

, 2013
Using a compilation of 379 massive (stellar mass M > 10^{11} M_Sun) spheroid-like galaxies from the near-infrared Palomar/DEEP-2 survey, we have probed, up to z~1, whether the presence of companions depends on the size of the host galaxies.
Barro, G., Cenarro, A. J., Díaz-García, L. A., López-Sanjuan, C., Mármol-Queraltó, E., Pérez-González, P. G., Trujillo, I.   +6 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Selection effects in the black hole-bulge relation and its evolution [PDF]

, 2011
We present an investigation of sample selection effects that influence the observed black hole - bulge relations and its evolution with redshift. We provide a common framework in which all kinds of selection effects on the BH-bulge relations can be ...
A. Schulze, Abazajian, Adelberger, Batcheldor, Bell, Bennert, Bentz, Bentz, Bernardi, Bernardi, Bezanson, Blandford, Bluck, Bongiorno, Booth, Booth, Bower, Bundy, Cattaneo, Chae, Croom, Croton, Croton, Dalla Bontà, Decarli, Di Matteo, Di Matteo, Emsellem, Fan, Ferrarese, Ferrarese, Ferrarese, Fine, Fontana, Franceschini, Gadotti, Gebhardt, Gebhardt, Gebhardt, Graham, Graham, Graham, Greene, Greene, Gültekin, Gültekin, Hasinger, Hasinger, Hirschmann, Hopkins, Hopkins, Hopkins, Hu, Häring, Ilbert, Inskip, Jahnke, Jahnke, Jahnke, Jiang, Johansson, Kaspi, Kaspi, Kauffmann, Kauffmann, Kelly, Kim, Kisaka, Kochanek, Kormendy, Kormendy, L. Wisotzki, Lamastra, Lauer, Lilly, Magorrian, Malbon, Marconi, Marconi, Marconi, Marulli, McLeod, McLure, McLure, Merloni, Merloni, Merloni, Merloni, Nelson, Nesvadba, Onken, Peng, Peng, Peng, Peterson, Pozzetti, Richards, Richards, Riechers, Riechers, Robertson, Salviander, Sarria, Schmidt, Schramm, Schulze, Schulze, Schulze, Shankar, Shen, Shen, Sheth, Shields, Shields, Sijacki, Somerville, Somerville, Tremaine, Treu, Trump, Ueda, Van den Berk, Van den Berk, van den Bosch, van der Marel, Vestergaard, Vestergaard, Vestergaard, Volonteri, Walter, Wang, Willott, Wisotzki, Woo, Woo, Woo, Wyithe, Yu, Yu   +138 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Establishment of a 3D spheroid culture system to evaluate the responsiveness of uterine leiomyoma cells to female hormones

Reproductive Medicine and Biology
Purpose Uterine leiomyomas (ULMs) are classified into those with and without MED12 mutations (MED12m(+) and MED12m(−), respectively). This study was undertaken to establish a culture system to evaluate the effect of female hormones on the growth of ULM ...
Takahiro Sakai, Shun Sato, Tetsuro Tamehisa, Hitomi Takasaki, Takuya Kajimura, Isao Tamura, Norihiro Sugino   +6 more
doaj   +1 more source

mTOR Pathway Inhibition, Anticancer Activity and In Silico Calculations of Novel Hydrazone Derivatives in Two- and Three-Dimensional Cultured Type 1 Endometrial Cancer Cells

Pharmaceuticals
Background: Endometrial cancer remains a significant health concern, with type 1 endometrial cancer characterized by aberrant expression of estrogen-dependent and mTOR pathway proteins.
Muhammet Volkan Bulbul, Arif Mermer, Bircan Kolbasi, Fatih Kocabas, Semiha Mervenur Kalender, Kiymet Asli Kirectepe Aydin, Turan Demircan, İlknur Keskin   +7 more
doaj   +1 more source