Results 61 to 70 of about 130,558 (351)
Microwell-Based Flow Culture Increases Viability and Restores Drug Response in Prostate Cancer Spheroids [PDF]
, 2022 Marie C. Payne +9 more
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Frontiers in Veterinary ScienceIntroductionMesenchymal stem cells (MSCs) have been introduced as a treatment for dogs owing to their immunomodulatory effects. In humans, 3D-cultured MSCs have recently been applied in treating various conditions, including myocardial infarction, liver ...
Eunbi Lee +6 more
doaj +1 more source
Pharmaceutics, 2019 The efficiency of delivering a therapeutic agent into a tumor is among the crucial factors determining the prospects for its clinical use. This problem is particularly acute in the case of targeted antitumor agents since many of them are high-molecular ...
Evgeniya Sokolova +7 more
doaj +1 more source
Development of a stem cell spheroid‐laden patch with high retention at skin wound site
Bioengineering & Translational Medicine, 2022 Mesenchymal stem cells such as human adipose tissue‐derived stem cells (hADSCs) have been used as a representative therapeutic agent for tissue regeneration because of their high proliferation and paracrine factor‐secreting abilities.
Gun‐Jae Jeong +11 more
doaj +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Screening of charged spheroidal colloidal particles
, 2010 We study the effective screened electrostatic potential created by a spheroidal colloidal particle immersed in an electrolyte, within the mean field approximation, using Poisson--Botzmann equation in its linear and nonlinear forms, and also beyond the ...
Allen M. P. +5 more
core +1 more source
In silico estimates of the free energy rates in growing tumor spheroids [PDF]
, 2010 The physics of solid tumor growth can be considered at three distinct size scales: the tumor scale, the cell-extracellular matrix (ECM) scale and the sub-cellular scale. In this paper we consider the tumor scale in the interest of eventually developing a
Garikipati, K. +4 more
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
From Supermassive Black Holes to Dwarf Elliptical Nuclei: a Mass Continuum
, 2006 Considerable evidence suggests that supermassive black holes reside at the centers of massive galactic bulges. At a lower galactic mass range, many dwarf galaxies contain extremely compact nuclei that structurally resemble massive globular clusters.
Elizabeth H. Wehner +5 more
core +1 more source