Results 61 to 70 of about 117,630 (212)

Penetration Efficiency of Antitumor Agents in Ovarian Cancer Spheroids: The Case of Recombinant Targeted Toxin DARPin-LoPE and the Chemotherapy Drug, Doxorubicin

Pharmaceutics, 2019
The efficiency of delivering a therapeutic agent into a tumor is among the crucial factors determining the prospects for its clinical use. This problem is particularly acute in the case of targeted antitumor agents since many of them are high-molecular ...
Evgeniya Sokolova, Olga Kutova, Alena Grishina, Anton Pospelov, Evgeniy Guryev, Alexey Schulga, Sergey Deyev, Irina Balalaeva   +7 more
doaj   +1 more source

Development of a stem cell spheroid‐laden patch with high retention at skin wound site

Bioengineering & Translational Medicine, 2022
Mesenchymal stem cells such as human adipose tissue‐derived stem cells (hADSCs) have been used as a representative therapeutic agent for tissue regeneration because of their high proliferation and paracrine factor‐secreting abilities.
Gun‐Jae Jeong, Gwang‐Bum Im, Tae‐Jin Lee, Sung‐Won Kim, Hye Ran Jeon, Dong‐Hyun Lee, Sangyul Baik, Changhyun Pang, Tae‐Hyung Kim, Dong‐Ik Kim, Young Charles Jang, Suk Ho Bhang   +11 more
doaj   +1 more source

Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity.

Acta Biomaterialia, 2018
The preclinical drug screening of pancreatic cancer treatments suffers from the absence of appropriate models capable to reproduce in vitro the heterogeneous tumor microenvironment and its stiff desmoplasia.
G. Lazzari, V. Nicolas, M. Matsusaki, M. Akashi, P. Couvreur, S. Mura   +5 more
semanticscholar   +1 more source

Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures

Nature Communications, 2019
Understanding how forces orchestrate tissue formation requires technologies to map internal tissue stress at cellular length scales. Here, we develop ultrasoft mechanosensors that visibly deform under less than 10 Pascals of cell-generated stress.
Wontae Lee, N. Kalashnikov, Stephanie Mok, Ruba Halaoui, Elena Kuzmin, A. J. Putnam, S. Takayama, Morag Park, L. McCaffrey, Ruogang Zhao, R. Leask, C. Moraes   +11 more
semanticscholar   +1 more source

Crizotinib Inhibits Viability, Migration, and Invasion by Suppressing the c-Met/PI3K/Akt Pathway in the Three-Dimensional Bladder Cancer Spheroid Model

Current Oncology
We aimed to evaluate the therapeutic potential of crizotinib, a broad-spectrum tyrosine kinase inhibitor against bladder cancer (BC) cells, based on a three-dimensional (3D) cell culture system.
Byeongdo Song, Danhyo Kim, Jin-Nyoung Ho, Van-Hung Le, Sangchul Lee   +4 more
doaj   +1 more source

Microfluidic Biofabrication of 3D Multicellular Spheroids by Modulation of Non-geometrical Parameters

Frontiers in Bioengineering and Biotechnology, 2020
Three-dimensional (3D) cell spheroids are being increasingly applied in many research fields due to their enhanced biological functions as compared to conventional two-dimensional (2D) cultures.
Silvia Lopa, Francesco Piraino, Giuseppe Talò, Valerio Luca Mainardi, Valerio Luca Mainardi, Simone Bersini, Margherita Pierro, Luigi Zagra, Marco Rasponi, Matteo Moretti, Matteo Moretti   +10 more
doaj   +1 more source

Nanofabrication of Nonfouling Surfaces for Micropatterning of Cell and Microtissue

Molecules, 2010
Surface engineering techniques for cellular micropatterning are emerging as important tools to clarify the effects of the microenvironment on cellular behavior, as cells usually integrate and respond the microscale environment, such as chemical and ...
Hidenori Otsuka
doaj   +1 more source

TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties

Stem Cell Research & Therapy, 2023
Background Cancer stem cells (CSCs) play an important role in endometrial cancer progression and it is potential to isolate CSCs from spheroid cells. Further understanding of spheroid cells at protein level would help find novel CSC markers.
Mingzhu Cao, Zhi Liu, Danming You, Yingying Pan, Qingyan Zhang   +4 more
doaj   +1 more source

3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK

bioRxiv, 2019
Mechanical properties of cancer cells and their microenvironment contribute to breast cancer progression. While mechanosensing has been extensively studied using two-dimensional (2D) substrates, much less is known about it in a physiologically more ...
A. Taubenberger, S. Girardo, Nicole Träber, Elisabeth Fischer‐Friedrich, M. Kräter, Katrin Wagner, T. Kurth, Isabel Richter, B. Haller, M. Binner, D. Hahn, U. Freudenberg, C. Werner, J. Guck   +13 more
semanticscholar   +1 more source

Cell spheroid fusion: beyond liquid drops model

Scientific Reports, 2020
Biological self-assembly is crucial in the processes of development, tissue regeneration, and maturation of bioprinted tissue-engineered constructions.
N. Kosheleva, Y. Efremov, B. Shavkuta, I. Zurina, De‐ying Zhang, Yuanyuan Zhang, N. Minaev, A. Gorkun, Shicheng Wei, A. Shpichka, I. Saburina, P. Timashev   +11 more
semanticscholar   +1 more source