Results 71 to 80 of about 130,558 (351)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Crizotinib Inhibits Viability, Migration, and Invasion by Suppressing the c-Met/PI3K/Akt Pathway in the Three-Dimensional Bladder Cancer Spheroid Model

Current Oncology
We aimed to evaluate the therapeutic potential of crizotinib, a broad-spectrum tyrosine kinase inhibitor against bladder cancer (BC) cells, based on a three-dimensional (3D) cell culture system.
Byeongdo Song, Danhyo Kim, Jin-Nyoung Ho, Van-Hung Le, Sangchul Lee   +4 more
doaj   +1 more source

Modeling the growth of multicellular cancer spheroids in a\ud bioengineered 3D microenvironment and their treatment with an\ud anti-cancer drug [PDF]

, 2010
A critical step in the dissemination of ovarian cancer cells is the formation of multicellular spheroids from cells shed from the primary tumor.
Byrne, H. M., Clements, J. A., Flegg, J. A., Hall, C. L., Hutmacher, D. W., Loessner, D., McElwain, D. L. S., Moroney, T. J.   +7 more
core  

The interface stiffness and topographic feature dictate interfacial invasiveness of cancer spheroids [PDF]

, 2022
Bin-Hsu Mao, Kim Mai Nguyen Thi, Ming‐Jer Tang, Roger D. Kamm, Ting‐Yuan Tu   +4 more
openalex   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Microfluidic Biofabrication of 3D Multicellular Spheroids by Modulation of Non-geometrical Parameters

Frontiers in Bioengineering and Biotechnology, 2020
Three-dimensional (3D) cell spheroids are being increasingly applied in many research fields due to their enhanced biological functions as compared to conventional two-dimensional (2D) cultures.
Silvia Lopa, Francesco Piraino, Giuseppe Talò, Valerio Luca Mainardi, Valerio Luca Mainardi, Simone Bersini, Margherita Pierro, Luigi Zagra, Marco Rasponi, Matteo Moretti, Matteo Moretti   +10 more
doaj   +1 more source

TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties

Stem Cell Research & Therapy, 2023
Background Cancer stem cells (CSCs) play an important role in endometrial cancer progression and it is potential to isolate CSCs from spheroid cells. Further understanding of spheroid cells at protein level would help find novel CSC markers.
Mingzhu Cao, Zhi Liu, Danming You, Yingying Pan, Qingyan Zhang   +4 more
doaj   +1 more source

Stokesian swimming of a prolate spheroid at low Reynolds number

, 2016
The swimming of a spheroid immersed in a viscous fluid and performing surface deformations periodically in time is studied on the basis of Stokes equations of low Reynolds number hydrodynamics.
Felderhof, B. U.
core   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Nanofabrication of Nonfouling Surfaces for Micropatterning of Cell and Microtissue

Molecules, 2010
Surface engineering techniques for cellular micropatterning are emerging as important tools to clarify the effects of the microenvironment on cellular behavior, as cells usually integrate and respond the microscale environment, such as chemical and ...
Hidenori Otsuka
doaj   +1 more source