Results 61 to 70 of about 9,343 (242)
VIEW, EarlyView.This study established clinical cohorts of respiratory viral infections and identified sphinganine‐phosphate (SA) as a metabolite significantly upregulated post‐infection through metabolomic analysis. In vitro and in vivo experiments demonstrated that SA promotes the generation of effector CD8+ T cells via the SOCS1/JAK1/STAT1 pathway, which ...
Zhongwen Hu +10 more
wiley +1 more source
Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.
Journal of Lipid Research, 1994 The syntheses of D-erythro-sphingosine-1-phosphate and DL-erythro-sphinganine-1-phosphate are described starting from the commercially available D-erythro-sphingosine and DL-erythro-sphinganine.
A Boumendjel, S P Miller
doaj +1 more source
Pediatric Dermatology, EarlyView.ABSTRACT Background/Objective Growing evidence highlights the role of physiological lipids, namely ceramides, cholesterol, and free fatty acids, in maintaining skin barrier function and preventing atopic dermatitis (AD). Current evidence on the efficacy, safety, and clinical relevance of stratum corneum (SC) lipid‐based therapies to prevent AD and ...
Chon‐Wai Jeremy Chan +1 more
wiley +1 more source
Clinical and Translational Medicine, 2023 Background Metabolic dependencies of chronic lymphocytic leukaemia (CLL) cells may represent new personalized treatment approaches in patients harbouring unfavourable features.
Flora Nguyen Van Long +10 more
doaj +1 more source
Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence. [PDF]
, 2019 Although aging is considered to be an unavoidable event, recent experimental evidence suggests that the process can be counteracted. Intracellular calcium (Ca2+i) dyshomeostasis, mitochondrial dysfunction, oxidative stress, and lipid dysregulation are ...
Bomba, Manuela +12 more
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Journal of Basic Microbiology, Volume 66, Issue 2, February 2026.ABSTRACT Phytophthora parasitica is a generalist phytopathogenic oomycete that infects a series of crops with great economic interest, including tomato, tobacco, and citrus species. Sterols are essential lipids in eukaryotic organisms, playing a fundamental role in the structure and function of the cell membrane.
Pâmela Ponce Martins +7 more
wiley +1 more source
Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation [PDF]
, 2006 Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts both as an extracellular ligand for endothelial differentiation gene receptor family and as an intracellular second messenger.
Brancaleone, V +9 more
core +1 more source
Andrology, Volume 14, Issue 2, Page 496-515, February 2026.Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma +8 more
wiley +1 more source
Production and purification of fumonisins from a highly toxigenic Fusarium verticilloides strain [PDF]
, 2005 Fumonisins are the major mycotoxins produced by Fusarium verticilloides and F. proliferatum fungi which are widely found as contaminants in corn and corn screenings.
Bailly, Jean Denis +3 more
core
Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells [PDF]
, 2013 Sphingosine 1-phosphate (S1P) is involved in hyper-proliferative diseases such as cancer and pulmonary arterial hypertension. We have synthesized inhibitors that are selective for the two isoforms of sphingosine kinase (SK1 and SK2) that catalyze the ...
Bittman, Robert +4 more
core +1 more source