Results 1 to 10 of about 48,095 (292)

The Role of Sphingolipid Metabolism and Neuron Death in Ischemic Stroke: A New Perspective from Bioinformatics [PDF]

Brain and Behavior
Background Ischemic stroke (IS) is a leading cause of death and disability worldwide, but traditional risk factors do not fully explain its pathophysiology. Neuronal death in IS is influenced by multiple pathways, including sphingolipid metabolism, which
Zhong‐can Chen, Fang‐biao Xu, Sen Hu, Qiang Cui, Hugo Andrade Barazarte, Jing Zhang, Li‐na Suo, Jian‐jun Gu, Jiang‐yu Xue   +8 more
doaj   +2 more sources

Sphingolipids [PDF]

Kidney International, 2000
A significant corpus of work over the last decade has firmly established an important role for sphingolipids in a variety of important biological processes. Such processes include signaling events related to cell growth, differentiation, programmed cell death, and stress responses. These processes not only involve those sphingolipids that accumulate as
Alfred Merrill, Eva-Marie Schmelz
openaire   +3 more sources

Using BODIPY FL-Sphingolipid Analogs to Study Sphingolipid Metabolism in Mouse Embryonic Stem Cells

Bio-Protocol, 2022
Sphingolipids are important structural components of cellular membranes. They also function as prominent signaling molecules to control a variety of cellular events, such as cell growth, differentiation, and apoptosis.
Wei Fan, Xiaoling Li
doaj   +1 more source

A Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites

Cells, 2021
Sphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration.
Simon Peters, Ingo Fohmann, Thomas Rudel, Alexandra Schubert-Unkmeir   +3 more
doaj   +1 more source

Microdomain Protein Nce102 Is a Local Sensor of Plasma Membrane Sphingolipid Balance

Microbiology Spectrum, 2022
Sphingolipids are essential building blocks of eukaryotic membranes and important signaling molecules that are regulated tightly in response to environmental and physiological inputs.
Jakub Zahumenský, Caroline Mota Fernandes, Petra Veselá, Maurizio Del Poeta, James B. Konopka, Jan Malínský   +5 more
doaj   +1 more source

Identification and characterization of 3-ketosphinganine reductase activity encoded at the BT_0972 locus in Bacteroides thetaiotaomicron

Journal of Lipid Research, 2022
Bacterial sphingolipid synthesis is important for the fitness of gut commensal bacteria with an implied potential for regulating mammalian host physiology.
Min-Ting Lee, Henry H. Le, Kevin R. Besler, Elizabeth L. Johnson   +3 more
doaj   +1 more source

Effects of sphingolipid metabolism disorders on endothelial cells

Lipids in Health and Disease, 2022
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang   +4 more
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Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism

Cells, 2023
Currently, there are no animal models for studying both specific social fear and social fear with comorbidities. Here, we investigated whether social fear conditioning (SFC), an animal model with face, predictive and construct validity for social anxiety
Iulia Zoicas, Christiane Mühle, Fabian Schumacher, Burkhard Kleuser, Johannes Kornhuber   +4 more
doaj   +1 more source

Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae.

PLoS Genetics, 2020
Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoyl ...
Bianca M Esch, Sergej Limar, André Bogdanowski, Christos Gournas, Tushar More, Celine Sundag, Stefan Walter, Jürgen J Heinisch, Christer S Ejsing, Bruno André, Florian Fröhlich   +10 more
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Lipidomics Revealed Alteration of Sphingolipid Metabolism During the Reparative Phase After Myocardial Infarction Injury

Frontiers in Physiology, 2021
Aberrant sphingolipid metabolism contributes to cardiac pathophysiology. Emerging evidence found that an increased level of ceramide during the inflammatory phase of post-myocardial infarction (MI) served as a biomarker and was associated with cardiac ...
Tong Hua, Qiankun Bao, Xue He, Wenbin Cai, Jinlong He   +4 more
doaj   +1 more source