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The Emerging Mycotoxin 2-Amino-14, 16-Dimethyloctadecan-3-ol (AOD) Alters Transcriptional Regulation and Sphingolipid Metabolism and Undergoes N-Acylation by HepG2 Cells [PDF]

Toxins
2-Amino-14,16-dimethyloctadecan-3-ol (AOD) is commonly found in foods contaminated with Fusarium avenaceum, particularly cereals or fruits, and is structurally related to Fusarium mycotoxins (fumonisins) and mammalian sphingoid bases, especially 1 ...
Shenlong Mo, Zhenying Hu, Huaiyi Zhu, Boming Yu, Xiaoyan Chen, Yu Chen, Alfred H. Merrill, Jingjing Duan   +7 more
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Using BODIPY FL-Sphingolipid Analogs to Study Sphingolipid Metabolism in Mouse Embryonic Stem Cells

Bio-Protocol, 2022
Sphingolipids are important structural components of cellular membranes. They also function as prominent signaling molecules to control a variety of cellular events, such as cell growth, differentiation, and apoptosis.
Wei Fan, Xiaoling Li
doaj   +1 more source

A Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites

Cells, 2021
Sphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration.
Simon Peters, Ingo Fohmann, Thomas Rudel, Alexandra Schubert-Unkmeir   +3 more
doaj   +1 more source

Microdomain Protein Nce102 Is a Local Sensor of Plasma Membrane Sphingolipid Balance

Microbiology Spectrum, 2022
Sphingolipids are essential building blocks of eukaryotic membranes and important signaling molecules that are regulated tightly in response to environmental and physiological inputs.
Jakub Zahumenský, Caroline Mota Fernandes, Petra Veselá, Maurizio Del Poeta, James B. Konopka, Jan Malínský   +5 more
doaj   +1 more source

Identification and characterization of 3-ketosphinganine reductase activity encoded at the BT_0972 locus in Bacteroides thetaiotaomicron

Journal of Lipid Research, 2022
Bacterial sphingolipid synthesis is important for the fitness of gut commensal bacteria with an implied potential for regulating mammalian host physiology.
Min-Ting Lee, Henry H. Le, Kevin R. Besler, Elizabeth L. Johnson   +3 more
doaj   +1 more source

Effects of sphingolipid metabolism disorders on endothelial cells

Lipids in Health and Disease, 2022
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang   +4 more
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Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism

Cells, 2023
Currently, there are no animal models for studying both specific social fear and social fear with comorbidities. Here, we investigated whether social fear conditioning (SFC), an animal model with face, predictive and construct validity for social anxiety
Iulia Zoicas, Christiane Mühle, Fabian Schumacher, Burkhard Kleuser, Johannes Kornhuber   +4 more
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Lipidomics Revealed Alteration of Sphingolipid Metabolism During the Reparative Phase After Myocardial Infarction Injury

Frontiers in Physiology, 2021
Aberrant sphingolipid metabolism contributes to cardiac pathophysiology. Emerging evidence found that an increased level of ceramide during the inflammatory phase of post-myocardial infarction (MI) served as a biomarker and was associated with cardiac ...
Tong Hua, Qiankun Bao, Xue He, Wenbin Cai, Jinlong He   +4 more
doaj   +1 more source

Role of sphingolipid metabolites in the homeostasis of steroid hormones and the maintenance of testicular functions

Frontiers in Endocrinology, 2023
With the acceleration of life pace and the increase of work pressure, the problem of male infertility has become a social problem of general concern.
Defan Wang, Yedong Tang, Yedong Tang, Zhengchao Wang   +3 more
doaj   +1 more source

Uptake of exogenous serine is important to maintain sphingolipid homeostasis in Saccharomyces cerevisiae.

PLoS Genetics, 2020
Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoyl ...
Bianca M Esch, Sergej Limar, André Bogdanowski, Christos Gournas, Tushar More, Celine Sundag, Stefan Walter, Jürgen J Heinisch, Christer S Ejsing, Bruno André, Florian Fröhlich   +10 more
doaj   +1 more source