Results 11 to 20 of about 48,095 (292)

Role of sphingolipid metabolites in the homeostasis of steroid hormones and the maintenance of testicular functions

Frontiers in Endocrinology, 2023
With the acceleration of life pace and the increase of work pressure, the problem of male infertility has become a social problem of general concern.
Defan Wang, Yedong Tang, Yedong Tang, Zhengchao Wang   +3 more
doaj   +1 more source

Perturbations of Glutathione and Sphingosine Metabolites in Port Wine Birthmark Patient-Derived Induced Pluripotent Stem Cells

Metabolites, 2023
Port Wine Birthmarks (PWBs) are a congenital vascular malformation on the skin, occurring in 1–3 per 1000 live births. We have recently generated PWB-derived induced pluripotent stem cells (iPSCs) as clinically relevant disease models.
Vi Nguyen, Jacob Kravitz, Chao Gao, Marcelo L. Hochman, Dehao Meng, Dongbao Chen, Yunguan Wang, Anil G. Jegga, J Stuart Nelson, Wenbin Tan   +9 more
doaj   +1 more source

Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer

Scientific Reports, 2023
Ceramide, the central molecule in sphingolipid synthesis, is a bioactive lipid that serves as a regulatory molecule in the anti-inflammatory responses, apoptosis, programmed necrosis, autophagy, and cell motility of cancer cells.
Tamuro Hayama, Kotaro Hama, Tsuyoshi Ozawa, Yuko Fujiwara, Keijiro Nozawa, Keiji Matsuda, Kazuaki Yokoyama, Yojiro Hashiguchi, Hiroki Ochiai, Takeyuki Misawa, Takeo Fukagawa   +10 more
doaj   +1 more source

Oceanapiside, a Marine Natural Product, Targets the Sphingolipid Pathway of Fluconazole-Resistant Candida glabrata

Marine Drugs, 2021
Oceanapiside (OPS), a marine natural product with a novel bifunctional sphingolipid structure, is fungicidal against fluconazole-resistant Candida glabrata at 10 μg/mL (15.4 μM).
Doralyn S. Dalisay, Evan W. Rogers, Tadeusz F. Molinski   +2 more
doaj   +1 more source

Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry[S]

Journal of Lipid Research, 2018
Sphingolipids constitute a dynamic metabolic network that interconnects several bioactive molecules, including ceramide (Cer), sphingosine (Sph), Sph 1-phosphate, and Cer 1-phosphate.
Justin M. Snider, Ashley J. Snider, Lina M. Obeid, Chiara Luberto, Yusuf A. Hannun   +4 more
doaj   +1 more source

Molecular Classification of Genes Associated with Hypoxic Lipid Metabolism in Pancreatic Cancer

Biomolecules, 2022
Abnormal lipid metabolism often occurs under hypoxic microenvironment, which is an important energy supplement for cancer cell proliferation and metastasis.
Yaning Li, Xinyue Liang, Gang Che, Yutong Chen, Lisi Luo, Kecheng Liu, Rongzhi Xie, Linjuan Zeng   +7 more
doaj   +1 more source

Single-cell sequencing analysis related to sphingolipid metabolism guides immunotherapy and prognosis of skin cutaneous melanoma

Frontiers in Immunology, 2023
BackgroundWe explore sphingolipid-related genes (SRGs) in skin melanoma (SKCM) to develop a prognostic indicator for patient outcomes. Dysregulated lipid metabolism is linked to aggressive behavior in various cancers, including SKCM.
Yantao Ding, Yantao Ding, Yantao Ding, Zhijie Zhao, Huabao Cai, Yi Zhou, Yi Zhou, Yi Zhou, He Chen, Yun Bai, Zhenran Liu, Shengxiu Liu, Shengxiu Liu, Shengxiu Liu, Wenming Zhou, Wenming Zhou, Wenming Zhou   +16 more
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Current Trends and Changes in Use of Membrane Molecular Dynamics Simulations within Academia and the Pharmaceutical Industry

Membranes, 2023
There has been an almost exponential increase in the use of molecular dynamics simulations in basic research and industry over the last 5 years, with almost a doubling in the number of publications each year.
Stephan L. Watkins
doaj   +1 more source

A systematic simulation of the effect of salicylic acid on sphingolipid metabolism

Frontiers in Plant Science, 2015
The phytohormone salicylic acid (SA) affects plant development and defense responses. Recent studies revealed that SA also participates in the regulation of sphingolipid metabolism, but the details of this regulation remain to be explored.
Chao eShi, Jian eYin, Zhe eLiu, Jian-xin eWu, Qi eZhao, Jian eRen, Nan eYao   +6 more
doaj   +1 more source

Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling

Journal of Lipid Research, 2009
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) that affect protein structure and channel function.
Hiroko Hamai, Fannie Keyserman, Lynne M. Quittell, Tilla S. Worgall   +3 more
doaj   +1 more source