Results 11 to 20 of about 42,593 (240)
Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer
Scientific Reports, 2023 Ceramide, the central molecule in sphingolipid synthesis, is a bioactive lipid that serves as a regulatory molecule in the anti-inflammatory responses, apoptosis, programmed necrosis, autophagy, and cell motility of cancer cells.
Tamuro Hayama +10 more
doaj +1 more source
Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry[S]
Journal of Lipid Research, 2018 Sphingolipids constitute a dynamic metabolic network that interconnects several bioactive molecules, including ceramide (Cer), sphingosine (Sph), Sph 1-phosphate, and Cer 1-phosphate.
Justin M. Snider +4 more
doaj +1 more source
The Manifold Roles of Sphingolipids in Viral Infections
Frontiers in Physiology, 2021 Sphingolipids are essential components of eukaryotic cells. In this review, we want to exemplarily illustrate what is known about the interactions of sphingolipids with various viruses at different steps of their replication cycles.
Elita Avota +5 more
doaj +1 more source
A systematic simulation of the effect of salicylic acid on sphingolipid metabolism
Frontiers in Plant Science, 2015 The phytohormone salicylic acid (SA) affects plant development and defense responses. Recent studies revealed that SA also participates in the regulation of sphingolipid metabolism, but the details of this regulation remain to be explored.
Chao eShi +6 more
doaj +1 more source
Journal of Lipid Research, 2009 Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) that affect protein structure and channel function.
Hiroko Hamai +3 more
doaj +1 more source
Altered expression of glycobiology-related genes in Parkinson’s disease brain
Frontiers in Molecular Neuroscience, 2022 The precise mechanisms initiating and perpetuating the cellular degeneration in Parkinson’s disease (PD) remain unclear. There is decreased expression of the main brain gangliosides, and GM1 ganglioside in particular, in the PD brain along with decreased
Jay S. Schneider, Garima Singh
doaj +1 more source
Fumonisin B1: A Tool for Exploring the Multiple Functions of Sphingolipids in Plants
Frontiers in Plant Science, 2020 Fumonisin toxins are produced by Fusarium fungal pathogens. Fumonisins are structural analogs of sphingosine and potent inhibitors of ceramide synthases (CerSs); they disrupt sphingolipid metabolism and cause disease in plants and animals.
Hong-Yun Zeng, Chun-Yu Li, Nan Yao
doaj +1 more source
Crosslink between lipids and acute uveitis: a lipidomic analysis [PDF]
International Journal of Ophthalmology, 2018 AIM: To explore the roles of phospholipids and sphingolipids in the inflammatory process of uveitis. METHODS: Aqueous humor (AH) and the retina were obtained from endotoxin-induced uveitis (EIU) rats during the acute inflammation stage (24h after ...
Hai-Yan Wang +5 more
doaj +1 more source
Poultry Science, 2021 While previous studies have characterized the fatty acids and global lipid families of the chicken egg yolk, there have been no publications characterizing the individual lipids in these lipid families.
Paul L. Wood +12 more
doaj +1 more source
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source