Results 11 to 20 of about 68,956 (338)
Sphingolipids in Inflammation [PDF]
Mediators of Inflammation, 2018 The etiology of many diseases results from the dysregulation of inflammation. Understanding the molecular mechanisms controlling the inflammatory response is essential to formulate therapeutic strategies for the treatment of inflammatory conditions. In fact, substantial research has unveiled important aspects of the inflammatory machinery, both at the ...
Elisabetta Albi +2 more
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European Respiratory Review, 2019 Sphingolipids are a distinct class of lipid molecules widely found in nature, principally as cell membrane constituents. After initial uncertainty about their function, sphingolipids have been increasingly recognised to be metabolically active entities involved in many biological processes, including the control of inflammation. Their role as mediators
Raja Chandra Chakinala +4 more
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The Equilibria of Sphingolipid-Cholesterol and Sphingolipid–Sphingolipid in Monolayers at the Air–Water Interface [PDF]
The Journal of Membrane Biology, 2012 Monolayers of sphingomyelin (SM), ceramide (Cer) and cholesterol (Ch) and binary mixtures SM-Ch, SM-Cer and Cer-Ch were investigated at the air-water interface. SM, Cer and Ch were used in the experiment. The surface tension values of pure and mixed monolayers were used to calculate π-A isotherms.
Aneta D. Petelska +2 more
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Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer
Scientific Reports, 2023 Ceramide, the central molecule in sphingolipid synthesis, is a bioactive lipid that serves as a regulatory molecule in the anti-inflammatory responses, apoptosis, programmed necrosis, autophagy, and cell motility of cancer cells.
Tamuro Hayama +10 more
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Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]
, 2019 Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra +3 more
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Kidney International, 2000 A significant corpus of work over the last decade has firmly established an important role for sphingolipids in a variety of important biological processes. Such processes include signaling events related to cell growth, differentiation, programmed cell death, and stress responses. These processes not only involve those sphingolipids that accumulate as
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The Manifold Roles of Sphingolipids in Viral Infections
Frontiers in Physiology, 2021 Sphingolipids are essential components of eukaryotic cells. In this review, we want to exemplarily illustrate what is known about the interactions of sphingolipids with various viruses at different steps of their replication cycles.
Elita Avota +5 more
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Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations [PDF]
, 2009 Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic consequences.
A Caspi +84 more
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Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry[S]
Journal of Lipid Research, 2018 Sphingolipids constitute a dynamic metabolic network that interconnects several bioactive molecules, including ceramide (Cer), sphingosine (Sph), Sph 1-phosphate, and Cer 1-phosphate.
Justin M. Snider +4 more
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The Long and Viscous Road: Uncovering Nuclear Diffusion Barriers in Closed Mitosis [PDF]
, 2014 During Saccharomyces cerevisiae closed mitosis, parental identity is sustained by the asymmetric segregation of ageing factors. Such asymmetry has been hypothesized to occur via diffusion barriers, constraining protein lateral exchange in cellular ...
Marquez-Lago, Tatiana T., Zavala, Eder
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