Results 21 to 30 of about 42,593 (240)

Current Trends and Changes in Use of Membrane Molecular Dynamics Simulations within Academia and the Pharmaceutical Industry

Membranes, 2023
There has been an almost exponential increase in the use of molecular dynamics simulations in basic research and industry over the last 5 years, with almost a doubling in the number of publications each year.
Stephan L. Watkins
doaj   +1 more source

Ethylene modulates sphingolipid synthesis in Arabidopsis

Frontiers in Plant Science, 2015
Sphingolipids have essential structural and bioactive functions in membranes and in signaling. However, how plants regulate sphingolipid biosynthesis in the response to stress remains unclear.
Jian-xin eWu, Jia-Li eWu, Jian eYin, Ping eZheng, Nan eYao   +4 more
doaj   +1 more source

Nanofiber-Based Delivery of Bioactive Lipids Promotes Pro-regenerative Inflammation and Enhances Muscle Fiber Growth After Volumetric Muscle Loss

Frontiers in Bioengineering and Biotechnology, 2021
Volumetric muscle loss (VML) injuries after extremity trauma results in an important clinical challenge often associated with impaired healing, significant fibrosis, and long-term pain and functional deficits.
Cheryl L. San Emeterio, Lauren A. Hymel, Thomas C. Turner, Molly E. Ogle, Emily G. Pendleton, William Y. York, Claire E. Olingy, Alan Y. Liu, Hong Seo Lim, Todd A. Sulchek, Todd A. Sulchek, Todd A. Sulchek, Todd A. Sulchek, Gordon L. Warren, Luke J. Mortensen, Luke J. Mortensen, Peng Qiu, Peng Qiu, Young C. Jang, Young C. Jang, Nick J. Willett, Nick J. Willett, Nick J. Willett, Nick J. Willett, Edward A. Botchwey, Edward A. Botchwey   +25 more
doaj   +1 more source

Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease

Journal of Lipid Research, 2020
Sphingolipids have become established participants in the pathogenesis of obesity and its associated maladies. Sphingosine kinase 1 (SPHK1), which generates S1P, has been shown to increase in liver and adipose of obese humans and mice and to regulate ...
Andrea K. Anderson, Johana M. Lambert, David J. Montefusco, Bao Ngan Tran, Patrick Roddy, William L. Holland, L. Ashley Cowart   +6 more
doaj   +1 more source

The Emerging Mycotoxin 2-Amino-14, 16-Dimethyloctadecan-3-ol (AOD) Alters Transcriptional Regulation and Sphingolipid Metabolism and Undergoes N-Acylation by HepG2 Cells

Toxins
2-Amino-14,16-dimethyloctadecan-3-ol (AOD) is commonly found in foods contaminated with Fusarium avenaceum, particularly cereals or fruits, and is structurally related to Fusarium mycotoxins (fumonisins) and mammalian sphingoid bases, especially 1 ...
Shenlong Mo, Zhenying Hu, Huaiyi Zhu, Boming Yu, Xiaoyan Chen, Yu Chen, Alfred H. Merrill, Jingjing Duan   +7 more
doaj   +1 more source

Targeting Ceramides and Adiponectin Receptors in the Islet of Langerhans for Treating Diabetes

Molecules, 2022
Ceramides belong to the sphingolipid family and represent the central hub of the sphingolipid network. In obesity, oversupply of saturated fatty acids including palmitate raises ceramide levels which can be detrimental to cells.
Wen-hong Li
doaj   +1 more source

Ceramide Regulates Anti-Tumor Mechanisms of Erianin in Androgen-Sensitive and Castration-Resistant Prostate Cancers

Frontiers in Oncology, 2021
Prostate cancer is the second most prevalent malignancy worldwide. In the early stages, the development of prostate cancer is dependent on androgens. Over time with androgen deprivation therapy, 20% of prostate cancers progress to a castration-resistant ...
I Gusti Md Gde Surya C. Trapika, I Gusti Md Gde Surya C. Trapika, Xin Tracy Liu, Long Hoa Chung, Felcia Lai, Felcia Lai, Chanlu Xie, Chanlu Xie, Yang Zhao, Shaohui Cui, Jinbiao Chen, Collin Tran, Qian Wang, Shubiao Zhang, Anthony S. Don, Anthony S. Don, George Qian Li, Jane R. Hanrahan, Yanfei Qi   +18 more
doaj   +1 more source

Metabolism of HSAN1- and T2DM-associated 1-deoxy-sphingolipids inhibits the migration of fibroblasts

Journal of Lipid Research, 2021
Hereditary sensory neuropathy type 1 (HSAN1) is a rare axonopathy, characterized by a progressive loss of sensation (pain, temperature, and vibration), neuropathic pain, and wound healing defects.
Gergely Karsai, Regula Steiner, Andres Kaech, Museer A. Lone, Arnold von Eckardstein, Thorsten Hornemann   +5 more
doaj   +1 more source

Long non-coding RNAs-sphingolipid metabolism nexus: Potential targets for cancer treatment

Pharmacological Research
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of cancer pathogenesis, influencing various cellular processes and contributing to tumorigenesis.
Yan Chen, Jing Dai, Peng Chen, Quan Dai, Ya Chen, Yuying Li, Man Lu, Shugang Qin, Qiuju Wang   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source