Results 31 to 40 of about 48,095 (292)

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Long non-coding RNAs-sphingolipid metabolism nexus: Potential targets for cancer treatment

Pharmacological Research
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of cancer pathogenesis, influencing various cellular processes and contributing to tumorigenesis.
Yan Chen, Jing Dai, Peng Chen, Quan Dai, Ya Chen, Yuying Li, Man Lu, Shugang Qin, Qiuju Wang   +8 more
doaj   +1 more source

Lipidomics of the chicken egg yolk: high-resolution mass spectrometric characterization of nutritional lipid families

Poultry Science, 2021
While previous studies have characterized the fatty acids and global lipid families of the chicken egg yolk, there have been no publications characterizing the individual lipids in these lipid families.
Paul L. Wood, William Muir, Undine Christmann, Philippa Gibbons, Courtney L. Hancock, Cathleen M. Poole, Audrey L. Emery, Jesse R. Poovey, Casey Hagg, Jon H. Scarborough, Jordon S. Christopher, Alexander T. Dixon, Dustin J. Craney   +12 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Tubercidin enhances apoptosis in serum-starved and hypoxic mouse cardiomyocytes by inducing nuclear speckle condensation

BMC Cardiovascular Disorders
Tubercidin, known for its antimicrobial, antiparasitic, and anticancer effects, faces clinical limitations due to adverse effects, especially cardiotoxicity risks for those with ischemic cardiomyopathy.
Guowen Shen, Qingni Cheng, Lunmin Liang, Yaping Qin, Yunzhu Cao, Quanzhong Li, Shengjun Xiao   +6 more
doaj   +1 more source

The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism

mBio
Sphingofungins are sphinganine analog mycotoxins acting as inhibitors of serine palmitoyl transferases, enzymes responsible for the first step in the sphingolipid biosynthesis.
Katarina Jojić, Fabio Gherlone, Zoltán Cseresnyés, Alexander U. Bissell, Sandra Hoefgen, Stefan Hoffmann, Ying Huang, Slavica Janevska, Marc Thilo Figge, Vito Valiante   +9 more
doaj   +1 more source

Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease

Journal of Lipid Research, 2020
Sphingolipids have become established participants in the pathogenesis of obesity and its associated maladies. Sphingosine kinase 1 (SPHK1), which generates S1P, has been shown to increase in liver and adipose of obese humans and mice and to regulate ...
Andrea K. Anderson, Johana M. Lambert, David J. Montefusco, Bao Ngan Tran, Patrick Roddy, William L. Holland, L. Ashley Cowart   +6 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Orm2 promotes nitrogen-induced sphingolipid production and endocytosis via Orm1 phosphorylation

Journal of Lipid Research
The Orm family of proteins inhibit serine palmitoyltransferase—the enzyme that catalyzes the first step in sphingolipid synthesis. In S. cerevisiae, the two Orm proteins are thought to function redundantly in suppressing sphingolipid production. Here, we
Jihui Ren, Yusuf A. Hannun
doaj   +1 more source