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Sphingolipid Signaling in Metabolic Disorders [PDF]
Cell Metabolism, 2012 Sphingolipids, ubiquitous membrane lipids in eukaryotes, carry out a myriad of critical cellular functions. The past two decades have seen significant advances in sphingolipid research, and in 2010 a first sphingolipid receptor modulator was employed as a human therapeutic. Furthermore, cellular signaling mechanisms regulated by sphingolipids are being
Timothy Hla, Andrew Jess Dannenberg
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Sphingolipid Signaling Mediates Iron Toxicity [PDF]
Cell Metabolism, 2012 Iron constitutes a major source of toxicity due to its ability to generate reactive oxygen species that can damage cellular macromolecules. However, the precise mechanism by which exposure to high iron concentrations results in cellular toxicity remains unknown.
Anthony K Henras +2 more
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Sphingolipid depletion impairs endocytic traffic and inhibits Wingless signaling [PDF]
Mechanisms of Development, 2013 Sphingolipids are an important part of the plasma membrane and implicated in a multitude of cellular processes. However, little is known about the role of sphingolipids in an epithelial context and their potential influence on the activity of signaling ...
George Hausmann +2 more
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Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease [PDF]
Archives of Toxicology, 2014 Resveratrol, a natural compound endowed with multiple health-promoting effects, has received much attention given its potential for the treatment of cardiovascular, inflammatory, neurodegenerative, metabolic and age-related diseases.
Simon P Mackay, Nigel J Pyne, Susan Pyne
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Sphingolipid signalling and liver diseases
Liver International, 2007AbstractSphingolipids (SLs) comprise a class of lipids with important structural functions and increasing relevance in cellular signalling. In particular, ceramide has attracted considerable attention owing to its role as a second messenger modulating several cell functions such as proliferation, gene expression, differentiation, cell cycle arrest and ...
Marí, Montserrat +1 more
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Sphingolipid signaling and redox regulation
Free Radical Biology and Medicine, 2006Sphingolipids including ceramide and its derivatives such as ceramide-1-phosphate, glycosyl-ceramide, and sphinogosine (-1-phosphate) are now recognized as novel intracellular signal mediators for regulation of inflammation, apoptosis, proliferation, and differentiation.
Je-Seong, Won, Inderjit, Singh
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Physiology and pathophysiology of sphingolipid metabolism and signaling
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2000Thomas Kolter +2 more
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Second Messengers: Sphingolipid signalling
Current Biology, 1994Sphingomyelin metabolites seem increasingly likely to be intracellular messengers controlling a variety of cell activities, but it is not yet clear exactly which metabolites control which functions, or how they do so.
R H, Michell, M J, Wakelam
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Breast cancer and sphingolipid signalling
Journal of Dairy Research, 2005Cancer develops from overlapping events that tend to deregulate the metabolism and unbalance the homeostasis of cells. Sphingolipids, major components of biological membranes, are also mediators of intracellular signalling. Their metabolism can be influenced by diverse stimuli and the accumulation or deficiency of intermediates may trigger ...
R. Ghidoni, P. Signorelli
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Sphingolipids and cell signalling
Journal of Inherited Metabolic Disease, 1998AbstractThe sphingolipid storage disorders constitute a group of inherited metabolic disorders in which the structure of the stored sphingolipid and the corresponding genetic defect have been established. However, the pathological mechanism(s) behind the disorders has not been fully elucidated.
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