Results 231 to 240 of about 851,389 (262)
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Sphingolipid metabolites in neural signalling and function
Brain Research Reviews, 2004Sphingolipid metabolites, such as ceramide, sphingosine, sphingosine-1-phosphate (S1P) and complex sphingolipids (gangliosides), are recognized as molecules capable of regulating a variety of cellular processes. The role of sphingolipid metabolites has been studied mainly in non-neuronal tissues.
Colombaioni L, GarciaGil M
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Sphingolipid signaling in gonadal development and function
Chemistry and Physics of Lipids, 1999Sphingolipid second messengers, such as ceramide and sphingosine-1-phosphate, signal proliferation, differentiation and death in mammalian cells. The object of this article is to highlight the potential impact of this new information on the study of female and male gonadal development and function.
J L, Tilly, R N, Kolesnick
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Sphingolipids in mammalian cell signalling
Cellular and Molecular Life Sciences, 2001Sphingolipids and their metabolites, ceramide, sphingosine and sphingosine-1-phosphate, are involved in a variety of cellular processes including differentiation, cellular senescence, apoptosis and proliferation. Ceramide is the main second messenger, and is produced by sphingomyelinase-induced hydrolysis of sphingomyelin and by de novo synthesis. Many
Ohanian, J, Ohanian, V.
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Role of sphingolipids in the cytoplasmic signaling of estrogens
Steroids, 2009Recent studies have clearly demonstrated that estrogen signaling is not limited by the canonical 'genomic' pathway. Estrogens have been shown to interact with multiple cytoplasmic signaling networks including that of growth factors, cytokines, and the most recently recognised participants, sphingolipids.
Wadham, Carol +2 more
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Sphingolipids, new players in plant signaling
Trends in Plant Science, 2003Sphingolipids are a diverse group of compounds, some of which play important signaling roles in animals and yeast. Results from recent research suggest that not only do plants contain components present in animal sphingolipid signaling pathways but that they might also possess novel plant-specific sphingolipid signaling systems.
Worrall, Dawn +2 more
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Sphingolipid Signaling in Epidermal Homeostasis
Skin Pharmacology and Physiology, 2001In the present review we have attempted to give an overview of the role of sphingolipids in skin homoeostasis. Sphingolipid metabolites are emerging as potent second messengers in diverse cellular signaling pathways. In the skin little is known about sphingolipids in signaling events.
Christoph C. Geilen +2 more
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Basics of Sphingolipid Metabolism and Signalling
2015The term sphingolipid was coined by J.L.W. Thudichum before the turn of the nineteenth century, referring to the enigmatic (related to the Sphinx myth) nature of this class of molecules. One hundred thirty years later, the enigma is not yet completely solved.
Céline Colacios +4 more
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Regulation of sphingosine kinase and sphingolipid signaling
Trends in Biochemical Sciences, 2011Bioactive sphingolipids, including ceramide, sphingosine and sphingosine 1-phosphate are important regulators of many cellular processes, including cell survival, proliferation, differentiation, migration and immune responses. Although the levels of these bioactive sphingolipids are regulated by complex pathways subject to spatial and temporal control,
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Sphingolipids and cell signaling: Involvement in apoptosis and atherogenesis
Biochemistry (Moscow), 2006This review considers various functional aspects of cell sphingolipids (sphingomyelin, ceramides) and lysosphingolipids (sphingosine-1-phosphate (S1P) and sphingosine phosphorylcholine). Good evidence now exists that they are actively involved in numerous cell-signaling processes.
O M, Ipatova +3 more
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Sphingolipid metabolism and signaling in atherosclerosis
2003Publisher Summary This chapter focuses on the enzymes that are involved in the metabolism of the sphingolipids and on some representative bioactive sphingolipids that have been implicated in mediating signaling events that contribute to phenotypic changes in cells. In particular, the chapter focuses on ceramide (Cer), sphingosine-l-phosphate (S-l-P),
Subroto Chatterjee, Sergio F. Martin
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