Results 101 to 110 of about 39,549 (288)

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens [PDF]

, 2020
Sandeep Kumar, Jinmei Li, Jiwoong Park, Sydney K. Hart, Niki Song, Damon T. Burrow, Nicholas L. Bean, Nicholas C. Jacobs, Ariella Coler‐Reilly, Anastasiia Onyshchenko, Tanya H. Pierre, India C. Bradley, Jan E. Carette, Malini Varadarajan, Thijn R. Brummelkamp, Roland E. Dolle, Timothy R. Peterson   +16 more
openalex   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Supplemental Figure 1 from Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis

, 2023
Yun‐Chi Tang, Hui Yuwen, Kaiying Wang, Peter M. Bruno, Kevin Bullock, Amy Deik, Stefano Santaguida, Marianna Trakala, Sarah J. Pfau, Na Zhong, Tao Huang, Lan Wang, Clary B. Clish, Michael T. Hemann, Angelika Amon   +14 more
openalex   +1 more source

Sphingolipids in apoptosis.

Experimental oncology, 2013
Forty years ago, the term "apoptosis" was introduced to describe a form of programmed cell death. Key players that mediate apoptosis at the molecular level such as caspases, death receptors, Bcl-2 family members have since been identified and their regulation remains a research focus of many laboratories.
Tirodkar, T.S., Voelkel-Johnson, C.
openaire   +2 more sources

Gut Microbiota–Metabolism Axis Shapes the Individual Metabolic Phenotype of Different Microbiota‐Accessible Carbohydrates

Food Frontiers, EarlyView.
Specific MAC bioactivities are associated with gut biotransformation. ABSTRACT Increasing the intake of microbiota‐accessible carbohydrates (MACs) has emerged as a promising nutritional strategy for preventing metabolic diseases. However, the consistency of their beneficial effects remains unclear, hindering their optimized application.
Na‐Na Zhang, Guo‐Quan Shao, Xin‐Xin Guo, Jing‐Yi Zhang, Yang Li, Li‐Li Wang, Yue Zhang, Feng‐Zhong Wang, Li‐Tao Tong   +8 more
wiley   +1 more source

Supplementary Material from Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and <i>In vivo</i> Models for Intestinal and Prostate Cancer

, 2023
Holly Symolon, Anatoliy Bushnev, Qiong Peng, Harsha Ramaraju, Suzanne G. Mays, Jeremy C. Allegood, Sarah T. Pruett, M. Cameron Sullards, Dirck L. Dillehay, Dennis C. Liotta, Alfred H. Merrill   +10 more
openalex   +1 more source

Molecular Mechanism of Mulberrin Regulating Lipid Metabolism Homeostasis Based on the Gut–Liver Axis Fiaf/AMPK Signaling Pathway

Food Frontiers, EarlyView.
The molecular mechanism for mulberrin regulating lipid metabolism homeostasis. ABSTRACT Lipid metabolism disorders and the induced metabolic diseases have risen to become one of the primary public health issues. Our preliminary experimental results confirmed that mulberry leaf flavonoid extract exhibited efficacy in lipid metabolism regulation; the ...
Qian Li, Daorui Pang, Erna Li, Dongxu Xing, Fan Liu, Li Wang, Yuxiao Zou   +6 more
wiley   +1 more source

Potentiation of Sphingolipids and TGF-β in the human corneal stroma reveals intricate signaling pathway crosstalks

, 2023
Sarah E. Nicholas, Alexander J. Choi, Thi N. Lam, Sandip K. Basu, Nawajes Mandal, Dimitrios Karamichos   +5 more
openalex   +1 more source

Mechanism of Alfalfa in Enhancing Goose Egg Yolk Flavor: An Analysis Based on Metabolomics and Quantitative Lipidomics

Food Frontiers, EarlyView.
ABSTRACT Organic egg production requires daily provision of coarse feed, fresh or dried forage, and silage to poultry. This study employed flavoromics, metabolomics, and quantitative lipidomics to investigate the effects of replacing 0% (CK), 10% (T10), and 20% (T20) of the basal diet of laying geese with alfalfa (Medicago sativa L.) on the sensory ...
Baochao Bai, Rui Qiu, Gentu Ge, Mingjian Liu, Yichao Liu, Muqier Zhao, Weiqin Ma, Panjie Sheng, Yushan Jia, Zhijun Wang   +9 more
wiley   +1 more source