Results 131 to 140 of about 39,549 (288)

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, EarlyView.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

The diverse roles of sphingolipids in inflammatory bowel disease [PDF]

Chelsea L. Doll, Ashley J. Snider
openalex   +1 more source

Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence [PDF]

, 2019
Wee Siong Chew, Federico Torta, Shanshan Ji, Hyungwon Choi, Husna Begum, Xueling Sim, Chin Meng Khoo, Eric Yin Hao Khoo, Wei‐Yi Ong, Rob M. van Dam, Markus R. Wenk, E Shyong Tai, Deron R. Herr   +12 more
openalex   +1 more source

Environmental risks and sphingolipid signatures in adult asthma and its phenotypic clusters: a multicentre study [PDF]

, 2022
Chao‐Chien Wu, Chin‐Chou Wang, Wen‐Yu Chung, Chau‐Chyun Sheu, Yi‐Hsin Yang, Ming−Yen Cheng, Ruay-Sheng Lai, Sum‐Yee Leung, Chi‐Cheng Lin, Yu‐Feng Wei, Ching‐Hsiung Lin, Sheng‐Hao Lin, Jeng‐Yuan Hsu, Wei‐Chang Huang, Chia‐Cheng Tseng, Yung‐Fa Lai, Meng‐Hsuan Cheng, Huang‐Chi Chen, Chih‐Jen Yang, Shih‐Chang Hsu, Chian‐Heng Su, Chien‐Jen Wang, Huei‐Ju Liu, Hua‐Ling Chen, Yuan‐Ting Hsu, Chih‐Hsing Hung, Chon‐Lin Lee, Ming-Shyan Huang, Shau‐Ku Huang   +28 more
openalex   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Opinion article on lipidomics: Inherent challenges of lipidomic analysis of sphingolipids

, 2017
Alfred H. Merrill, M. Cameron Sullards
openalex   +2 more sources

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, EarlyView.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

The mechanism of sphingolipid processing revealed by a GALC-SapA complex structure [PDF]

, 2017
Chris H. Hill, Georgia M. Cook, Samantha J. Spratley, Stephen C. Graham, Janet E. Deane   +4 more
openalex   +1 more source

An ERAD‐independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis [PDF]

, 2022
Satarupa Bhaduri, Analine Aguayo, Yusuke Ohno, Marco Proietto, Jasmine Jung, Isabel Wang, Rachel Kandel, Narinderbir Singh, Ikran Ibrahim, Mario Dejung, Eric J. Bennett, Akio Kihara, Sonya E. Neal   +12 more
openalex   +1 more source

Plasmodesmata‐located proteins: The molecular hubs in noncell‐autonomous immunity

New Plant Protection, EarlyView.
Plasmodesmata serve as critical battlefields for plant immunity, regulated by diverse proteins. This article provides a comprehensive review of the regulatory mechanisms, challenges, and future directions concerning proteins located within plasmodesmata and their roles in plant defense responses.
Zheng Wu, Xiaoyi Shan
wiley   +1 more source