Results 1 to 10 of about 50,004 (207)
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
eLife, 2022 Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway.
Tolulope Sokoya +16 more
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The nutritional functions of dietary sphingomyelin and its applications in food
Frontiers in Nutrition, 2022 Sphingolipids are common structural components of cell membranes and are crucial for cell functions in physiological and pathophysiological conditions.
Fang Yang, Guoxun Chen
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Sphingomyelin in Human Breast Milk might be Essential for the Hippocampus Maturation
Frontiers in Bioscience-Landmark, 2022 Background: It has been established that sphingomyelin present human breast milk is useful for the brain maturation and cognitive development. At 10 days of breastfeeding the sphingomyelin content is double that present in cow’s milk and its content is ...
Elisabetta Albi +15 more
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Nature Communications, 2023 Although the human immunodeficiency virus type 1 lipid envelope has been reported to be enriched with host cell sphingomyelin and cholesterol, the molecular mechanism of the enrichment is not well understood.
Nario Tomishige +9 more
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The Multiple Roles of Sphingomyelin in Parkinson’s Disease
Biomolecules, 2021 Advances over the past decade have improved our understanding of the role of sphingolipid in the onset and progression of Parkinson’s disease. Much attention has been paid to ceramide derived molecules, especially glucocerebroside, and little on ...
Paola Signorelli +2 more
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Biochemistry and Biophysics Reports, 2016 Statins have pleiotropic properties which are involved in inhibiting the thrombogenic response. In this study, the effects of lovastatin on two phospholipids, phosphatidylcholine and sphingomyelin, were studied in cultured endothelial cells in the ...
Qi Zhou, Allan Luo, Fred A Kummerow
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Metabolism of sphingolipids by normal and atherosclerotic aorta of squirrel monkeys
Journal of Lipid Research, 1970 We studied the synthesis and hydrolysis of sphingomyelin by homogenates of aortic intima plus inner media from normal squirrel monkeys and from monkeys with nutritionally-induced atherosclerosis (6-10 mo on a semi-purified diet containing butter and ...
O.W. Portman, M. Alexander
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Foods, 2023 Lipid molecules, such as policosanol, ergosterol, sphingomyelin, omega 3 rich phosphatidylcholine, α-tocopherol, and sodium butyrate, have emerged as novel additions to the portfolio of bioactive lipids.
Francisca S. Teixeira +7 more
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Journal of Lipid Research, 1994 Macrophage acyl-CoA:cholesterol O-acyltransferase (ACAT), a key enzyme in atheroma foam cell formation, is stimulated by lipoproteins only after a “threshold” amount of cholesterol has accumulated in the cell.
A.K. Okwu +3 more
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Membranes, 2022 Artificial vesicles are important tools in membrane research because they enable studying membrane properties in controlled conditions. Giant unilamellar vesicles (GUVs) are specially interesting due to their similarity in size to eukaryotic cells.
Zvonimir Boban +4 more
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