The nutritional functions of dietary sphingomyelin and its applications in food
Frontiers in Nutrition, 2022 Sphingolipids are common structural components of cell membranes and are crucial for cell functions in physiological and pathophysiological conditions.
Fang Yang, Guoxun Chen
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The Multiple Roles of Sphingomyelin in Parkinson’s Disease
Biomolecules, 2021 Advances over the past decade have improved our understanding of the role of sphingolipid in the onset and progression of Parkinson’s disease. Much attention has been paid to ceramide derived molecules, especially glucocerebroside, and little on ...
Paola Signorelli +2 more
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Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol [PDF]
Journal of Lipid Research, 1999 25-Hydroxycholesterol negatively regulates cholesterol synthesis and activates cholesterol esterification in a variety of cultured cells. Concurrent with these effects, 25-hydroxycholesterol also stimulates the synthesis of sphingomyelin in Chinese ...
Thomas A. Lagace +3 more
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TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure
EMBO Journal, 2023 Invasive bacteria enter the cytosol of host cells through initial uptake into bacteria‐containing vacuoles (BCVs) and subsequent rupture of the BCV membrane, thereby exposing to the cytosol intraluminal, otherwise shielded danger signals such as glycans ...
Keith B Boyle +9 more
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Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair
Nature Communications, 2021 Lysosomes are vital organelles vulnerable to injuries from diverse materials. Failure to repair or sequester damaged lysosomes poses a threat to cell viability.
Patrick Niekamp +12 more
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Communications Biology, 2021 Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer’s disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated with ...
P. Baloni +60 more
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Sphingomyelin in Human Breast Milk might be Essential for the Hippocampus Maturation
Frontiers in Bioscience-Landmark, 2022 Background: It has been established that sphingomyelin present human breast milk is useful for the brain maturation and cognitive development. At 10 days of breastfeeding the sphingomyelin content is double that present in cow’s milk and its content is ...
Elisabetta Albi +15 more
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Nature Communications, 2023 Although the human immunodeficiency virus type 1 lipid envelope has been reported to be enriched with host cell sphingomyelin and cholesterol, the molecular mechanism of the enrichment is not well understood.
Nario Tomishige +9 more
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Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway
eLife, 2022 Sphingomyelin is a dominant sphingolipid in mammalian cells. Its production in the trans-Golgi traps cholesterol synthesized in the ER to promote formation of a sphingomyelin/sterol gradient along the secretory pathway.
Tolulope Sokoya +16 more
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Sphingomyelin synthase 1 mediates hepatocyte pyroptosis to trigger non-alcoholic steatohepatitis
Gut, 2020 Objective Lipotoxic hepatocyte injury is a primary event in non-alcoholic steatohepatitis (NASH), but the mechanisms of lipotoxicity are not fully defined.
E. Koh +23 more
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