Results 121 to 130 of about 8,799 (216)

Distinct CSF lipidomic profiles are associated with five proteomic subtypes in patients with Alzheimer's disease. [PDF]

open access: yesMol Neurodegener Adv
Malliou G   +11 more
europepmc   +1 more source

Synthetic Cells on Demand: From Molecular Stimuli to Cellular Functions

open access: yesChemSystemsChem, Volume 8, Issue 2, March 2026.
ABSTRACT Synthetic cells constructed via bottom‐up approaches using lipid or polymer vesicles have become essential tools for mimicking cellular functions and studying synthetic biological systems. These vesicles can undergo morphological changes and trigger internal reactions in response to external stimuli, such as osmotic pressure, temperature, pH ...
Masato Suzuki, Koki Kamiya
wiley   +1 more source

SPHINGOMYELIN

open access: yesJournal of Biological Chemistry, 1913
openaire   +1 more source

Stratum Corneum Ceramide Abnormalities in Atopic Dermatitis: Pathophysiology and Implications for Disease Management

open access: yesThe Journal of Dermatology, Volume 53, Issue 3, Page 380-387, March 2026.
ABSTRACT The stratum corneum, as the outermost layer of the skin, functions as a critical barrier that maintains cutaneous hydration and systemic homeostasis. Among its structural lipids, ceramides constitute the most abundant and diverse component. These molecules are essential for the formation of lamellar structures that secure barrier integrity ...
Takashi Sakai
wiley   +1 more source

Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice

open access: yesAging Cell, Volume 25, Issue 3, March 2026.
This study shows that oxidative changes in oocytes from aged female mice lead to lipid droplet accumulation and altered energy and retinoid metabolism. These changes persist in embryonic organs, triggering antioxidant responses in lipid‐rich tissues. Remarkably, altered profiles are transmitted across generations, reaching third generation, suggesting ...
Hafsa Gulzar   +8 more
wiley   +1 more source

Lactose‐Derived Carbohydrates Induce Sexually Dimorphic Nutritional Programming Effects on Lifespan in Drosophila melanogaster

open access: yesAging Cell, Volume 25, Issue 3, March 2026.
Early‐life co‐consumption of galactose and glucose (hydrolyzed lactose) programs Drosophila melanogaster lifespan in a sex‐specific manner. Particularly, the co‐consumption of galactose and glucose programs extended lifespan when female flies were challenged by obesogenic diets later in life, and this is concomitant with remodeling of lipid metabolism,
Peixin Sun   +7 more
wiley   +1 more source

Regulation of Lipid Dysmetabolism and Neuroinflammation Progression Linked With Alzheimer's Disease Through Modulation of Dgat2

open access: yesAging Cell, Volume 25, Issue 3, March 2026.
Drosophila and mouse models of Alzheimer's disease exhibit lipid accumulation and neuroinflammation, leading to progressive impairments in memory, locomotion, sleep, circadian rhythms, and synaptic integrity. Knockdown of Dgat2 reduces lipid accumulation and neuroinflammatory signaling, rescuing these deficits and highlighting a conserved, crossspecies
Archana Yadav   +7 more
wiley   +1 more source

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