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Can we know more about atherosclerosis in cyanotic patients with congenital heart disease-the potential role of sphingosine-1-phosphate? [PDF]

Front Cardiovasc Med
Nartowicz SA, Gabriel M, Janus M, Cieślewicz A, Malesza K, Bartczak-Rutkowska A, Lesiak M, Trojnarska O.   +7 more
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Sphingosine 1-phosphate receptors

Prostaglandins & Other Lipid Mediators, 2001
Sphingosine-1-phosphate (SPP) is a bioactive lipid produced from the metabolism of sphingomyelin. It is an important constituent of serum and regulates cell growth, survival, migration, differentiation and gene expression. Its mode of action has been enigmatic; however, recent findings have shown that a family of G-protein-coupled receptors (GPCR) of ...
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Sphingosine-1-Phosphate Phosphatases

Prostaglandins & Other Lipid Mediators, 2001
Sphingosine-1-phosphate is a potent proliferative, survival, and morphogenetic factor, acting as an extracellular ligand for the EDG family of G-protein-coupled receptors and possibly intracellularly through as yet, unidentified targets. It is produced within most, if not all cells by phosphorylation of sphingosine, and is an abundant serum lipid that ...
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Sphingosine 1-Phosphate Receptor Signaling

Annual Review of Biochemistry, 2009
The sphingosine 1-phosphate (S1P) receptor signaling system is a productive model system. A hydrophobic zwitterionic lysophospholipid ligand with difficult physical properties interacts with five high-affinity G protein–coupled receptors to generate multiple downstream signals.
Hugh, Rosen, Pedro J, Gonzalez-Cabrera, M Germana, Sanna, Steven, Brown   +3 more
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Sphingosine-1-phosphate receptor 3 signaling

Clinica Chimica Acta, 2021
Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates a series of physiological and pathological processes via binding to five S1P receptors (S1PR1-5). Although S1PR1-3 are widely expressed, the study of S1PRs, however, mainly addressed S1PR1 and S1PR2, and few studies focus on S1PR3-5.
Qian Li, Yi Li, Cai Lei, Ying Tan, Guanghui Yi   +4 more
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The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators

Neurology, 2011
Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has
Betty, Soliven, Veronique, Miron, Jerold, Chun   +2 more
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Inhibitors of sphingosine-1-phosphate metabolism (sphingosine kinases and sphingosine-1-phosphate lyase)

Chemistry and Physics of Lipids, 2016
Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. Among them, sphingosine 1 phosphate (S1P) is a recognized promoter of cell survival, also involved, inter alia, in inflammation and tumorigenesis processes. The knowledge and modulation of the enzymes implicated in the biosynthesis and degradation of S1P are ...
Pol, Sanllehí, José-Luis, Abad, Josefina, Casas, Antonio, Delgado   +3 more
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Sphingosine 1-Phosphate Breakdown in Platelets

Journal of Biochemistry, 2004
We examined the formation of sphingolipid mediators in platelets, which abundantly store, and release extracellularly, sphingosine 1-phosphate (Sph-1-P). Challenging [(3)H]Sph-labeled platelet suspensions with thrombin or 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in a decrease in Sph-1-P formation and an increase in sphingosine (Sph ...
Yutaka, Yatomi, Soichiro, Yamamura, Nobuo, Hisano, Kazuhiko, Nakahara, Yasuyuki, Igarashi, Yukio, Ozaki   +5 more
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Sphingosine 1-phosphate signalling in cancer

Biochemical Society Transactions, 2012
There is an increasing body of evidence demonstrating a critical role for the bioactive lipid S1P (sphingosine 1-phosphate) in cancer. S1P is synthesized and metabolized by a number of enzymes, including sphingosine kinase, S1P lyase and S1P phosphatases. S1P binds to cell-surface G-protein-coupled receptors (S1P1–S1P5) to elicit cell responses and can
Nigel J, Pyne, Francesca, Tonelli, Keng Gat, Lim, Jaclyn S, Long, Joanne, Edwards, Susan, Pyne   +5 more
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Sphingosine 1-phosphate: synthesis and release

Prostaglandins & Other Lipid Mediators, 2001
Sphingosine 1-phosphate (Sph-1-P) is a bioactive sphingolipid, acting both as an intracellular second messenger and extracellular mediator, in mammalian cells. In cell types where Sph-1-P acts as an intracellular messenger, stimulation-dependent synthesis of Sph-1-P, possibly resulting from sphingosine (Sph) kinase activation, is essential.
Y, Yatomi, Y, Ozaki, T, Ohmori, Y, Igarashi   +3 more
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