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Pleiotropic actions of sphingosine-1-phosphate
Progress in Lipid Research, 2003Sphingosine-1-phosphate (SIP) is a bioactive sphingolipid metabolite that regulates diverse cellular responses including, growth, survival, cytoskeleton rearrangements and movement. SIP plays an important role during development, particularly in vascular maturation and has been implicated in pathophysiology of cancer, wound healing, and atherosclerosis.
Kenneth, Watterson +3 more
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Sphingosine 1-phosphate: synthesis and release
Prostaglandins & Other Lipid Mediators, 2001Sphingosine 1-phosphate (Sph-1-P) is a bioactive sphingolipid, acting both as an intracellular second messenger and extracellular mediator, in mammalian cells. In cell types where Sph-1-P acts as an intracellular messenger, stimulation-dependent synthesis of Sph-1-P, possibly resulting from sphingosine (Sph) kinase activation, is essential.
Y, Yatomi +3 more
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Point-Counterpoint of Sphingosine 1-Phosphate Metabolism
Circulation Research, 2004Timothy Hla, Julie Saba
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Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate
Circulation Research, 2008, Timothy Hla, Yong-Moon Lee
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Sphingosine-1-Phosphate Induces an Antiinflammatory Phenotype in Macrophages
Circulation Research, 2008Kevin R Lynch +2 more
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