Results 11 to 20 of about 102,609 (313)

Sphingosylphosphorylcholine is a substrate for the Pseudomonas aeruginosa phospholipase C/sphingomyelinase, PlcH [PDF]

Microbiology Spectrum
Sphingolipids are critical to eukaryotic cell membrane structure and function and play important roles in a variety of host processes that impact infection.
Pauline DiGianivittorio, Kristin Schutz, Lauren A. Hinkel, Matthew J. Wargo   +3 more
doaj   +2 more sources

Sphingosine-1-phosphate affects myocardial vascular homeostasis by regulating the balance of sphingosine-1-phosphate receptors in the hearts of diabetic mice [PDF]

Journal of International Medical Research
Objective This study aimed to explore the effect of sphingosine-1-phosphate on vascular homeostasis in the myocardium of diabetic mice. Methods Bioinformatics analyses were performed to analyze the targets and function of sphingosine-1-phosphate in ...
Guozhu Jin, Hu Zhao, Lun Li, Qian Cao, Hui Yan   +4 more
doaj   +2 more sources

Lysosome-targeted multifunctional lipid probes reveal the sterol transporter NPC1 as a sphingosine interactor

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Diverse fatty molecules taken up by diet or generated by digestion of biological membranes rely on the lysosome for processing and further transport.
Janathan Altuzar, J. Notbohm, F. Stein, P. Haberkant, Pia Hempelmann, Saskia Heybrock, Jutta Worsch, P. Saftig, Doris Höglinger   +8 more
semanticscholar   +1 more source

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
A Kihara, A Kissenpfennig, A Kumar, A Martino, A Olivera, A Weigert, AD Christensen, Burkhard Kleuser, C Ocana-Morgner, C Ruedl, CC Norbury, CL Bennett, CL Bennett, DH Kaplan, DH Kaplan, E Guaguere, ES Trombetta, EY Seo, F Sparber, G Gollmann, G Schuhmachers, H Hackstein, H Liu, Heinfried H. Radeke, HH Radeke, I Reines, J Chun, Jagadeesh Bayry, JH Hong, K Kabashima, K Sarkar, K Takabe, Katrin Schaper, L Japtok, L Rose, L Ruwisch, LS Bursch, Lukasz Japtok, M Hara-Chikuma, M Matloubian, M Schröder, M Schuppel, MB Lutz, MC Kerr, ML Allende, ML Allende, N Romani, P Mitra, P Monti, R van de Ven, RH Kim, RM Steinman, S Spiegel, S Sullivan, S Xu, Se Kyoo Jeong, SH Wood, SP Zahner, T Hla, T Kitajima, T Walzer, V Brinkmann, W Baumer, W Baumer, W Baumer, Wolfgang Bäumer, Y Maeda, Y Yanagawa, YY Lan   +68 more
core   +10 more sources

Plasma S1P and Sphingosine are not Different Prior to Pre-Eclampsia in Women at High Risk of Developing the Disease

Journal of Lipid Research, 2023
Sphingolipids like sphingosine-1-phosphate (S1P) have been implicated in the pathophysiology of pre-eclampsia. We hypothesized that plasma S1P would be increased in women at high risk of developing pre-eclampsia who subsequently develop the disease.
Edward D. Johnstone, Melissa Westwood, Mark Dilworth, Jonathan R. Wray, Alexandra C. Kendall, Anna Nicolaou, Jenny E. Myers   +6 more
doaj   +1 more source

Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer

Advancement of science, 2022
SPHK1 (sphingosine kinase‐1) catalyzes the phosphorylation of sphingosine to sphingosine‐1‐phosphate (S1P), is found to be highly expressed in solid tumors.
Prachi Gupta, I. P. Kadamberi, Sonam Mittal, Shirng-Wern Tsaih, J. George, Sudhir Kumar, Dileep K Vijayan, Anjali Geethadevi, D. Parashar, Paytsar Topchyan, L. McAlarnen, B. Volkman, W. Cui, Kam Y. J. Zhang, D. Di Vizio, P. Chaluvally-Raghavan, S. Pradeep   +16 more
semanticscholar   +1 more source

The molecular mechanism of phytosphingosine binding to FFAR4/GPR120 differs from that of other fatty acids

FEBS Open Bio, 2021
Free fatty acid receptor 4 (FFAR4)/GPR120 comprises a receptor for medium‐ and long‐chain fatty acids. We previously identified phytosphingosine (PHS) as a novel ligand of FFAR4.
Tomotaka Nagasawa, Masaki Horitani, Shin‐ichi Kawaguchi, Shigeki Higashiyama, Yoichiro Hama, Susumu Mitsutake   +5 more
doaj   +1 more source

1-磷酸鞘氨醇在缺血性卒中中的作用研究进展 Research Progress on the Role of Sphingosine 1-Phosphate in Ischemic Stroke

Zhongguo cuzhong zazhi, 2023
脑组织缺血坏死后释放出炎性因子诱发炎症反应，并激活神经胶质细胞参与损伤后的级联免疫反应，1-磷酸鞘氨醇（sphingosine 1-phosphate，S1P）代谢与缺血性卒中具有相关性，神经胶质细胞在炎症状态下上调1-磷酸鞘氨醇受体（sphingosine 1-phosphate receptors，S1PRs）的表达，S1PRs发出S1P信号参与脑组织中炎症介质的上调，S1P与S1PRs结合参与缺血性卒中后炎症和免疫反应、内皮细胞的黏附和血管生成以及改善血脑屏障功能 ...
李萍，付胜奇
doaj   +1 more source

Sphingolipids as Modulators of SARS-CoV-2 Infection

Frontiers in Cell and Developmental Biology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic with severe consequences for afflicted individuals and the society as a whole.
Kid Törnquist, Kid Törnquist, Muhammad Yasir Asghar, Vignesh Srinivasan, Vignesh Srinivasan, Laura Korhonen, Dan Lindholm, Dan Lindholm   +7 more
doaj   +1 more source

The Functional Role of Sphingosine Kinase 2

Frontiers in Molecular Biosciences, 2021
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and
Rocio Diaz Escarcega, L. McCullough, Andrey S. Tsvetkov   +2 more
semanticscholar   +1 more source