Results 21 to 30 of about 102,609 (313)

Drugging Sphingosine Kinases [PDF]

ACS Chemical Biology, 2014
The transfer of the gamma phosphate from ATP to sphingosine (Sph) to generate a small signaling molecule, sphingosine 1-phosphate (S1P), is catalyzed by sphingosine kinases (SphK), which exist as two isoforms, SphK1 and SphK2. SphK is a key regulator of S1P and the S1P:Sph/ceramide ratio.
Santos, Webster L., Lynch, Kevin R.
openaire   +2 more sources

A Brief Review of FT-IR Spectroscopy Studies of Sphingolipids in Human Cells

Biophysica, 2023
In recent years, sphingolipids have attracted significant attention due to their pivotal role in cellular functions and physiological diseases.
Bahar Faramarzi, Martina Moggio, Nadia Diano, Marianna Portaccio, Maria Lepore   +4 more
doaj   +1 more source

Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects

Drugs, 2020
Lysophospholipids are a class of bioactive lipid molecules that produce their effects through various G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P) is perhaps the most studied lysophospholipid and has a role in a wide range of ...
J. Chun, G. Giovannoni, S. Hunter
semanticscholar   +1 more source

Effects of Fumonisin-Contaminated Corn on Growth Performance of 9 to 28 kg Nursery Pigs

Toxins, 2020
Fumonisin contamination in corn is an emerging issue in animal feed production. Fumonisin disrupts the metabolism of sphingolipids and reduces growth performance.
Zhong-Xing Rao, Mike D. Tokach, Jason C. Woodworth, Joel M. DeRouchey, Robert D. Goodband, Hilda I. Calderón, Steve S. Dritz   +6 more
doaj   +1 more source

Lung Transplantation for Adult Respiratory Distress Syndrome after SARS-CoV-2 Infection

The Thoracic & Cardiovascular Surgeon Reports, 2022
Background The majority of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection present mild symptoms. However, some patients develop severe acute respiratory distress syndrome (ARDS) and subsequent irreversible lung ...
Achim Koch, Nikolaus Pizanis, Vasiliki Bessa, Frank Herbstreit, Erich Gulbins, Clemens Aigner, Markus Kamler   +6 more
doaj   +1 more source

Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

Nature Communications, 2020
Immune checkpoint inhibitors (ICIs) have dramatically modified the prognosis of several advanced cancers, however many patients still do not respond to treatment.
C. Imbert, A. Montfort, M. Fraisse, E. Marcheteau, J. Gilhodes, E. Martin, Florie Bertrand, M. Marcellin, O. Burlet-Schiltz, A. G. Peredo, Virginie Garcia, S. Carpentier, S. Tartare-Deckert, P. Brousset, P. Rochaix, F. Puisset, T. Filleron, N. Meyer, L. Lamant, T. Levade, B. Ségui, N. Andrieu-Abadie, C. Colacios   +22 more
semanticscholar   +1 more source

Role of Sphingosine Kinase in Type 2 Diabetes Mellitus

Frontiers in Endocrinology, 2021
Sphingolipids are a class of essential lipids, functioning as both cell membrane constituents and signaling messengers. In the sphingolipid metabolic network, ceramides serve as the central hub that is hydrolyzed to sphingosine, followed by ...
Y. Qi, Wei Wang, Ziyu Song, Gulibositan Aji, Xin Tracy Liu, P. Xia   +5 more
semanticscholar   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

The Anti-Infectious Role of Sphingosine in Microbial Diseases

Cells, 2021
Sphingolipids are important structural membrane components and, together with cholesterol, are often organized in lipid rafts, where they act as signaling molecules in many cellular functions.
Yuqing Wu, Yongjie Liu, E. Gulbins, H. Grassmé   +3 more
semanticscholar   +1 more source

Sepsis-Associated Encephalopathy: The Blood–Brain Barrier and the Sphingolipid Rheostat

Frontiers in Immunology, 2017
Sepsis is not only a significant cause of mortality worldwide but has particularly devastating effects on the central nervous system of survivors. It is therefore crucial to understand the molecular structure, physiology, and events involved in the ...
Stephen J. Kuperberg, Raj Wadgaonkar
doaj   +1 more source