Results 11 to 20 of about 37,595 (198)
Arteriosclerosis, Thrombosis, and Vascular Biology, 2009 Sphingosine-1 phosphate (S1P) is a bioactive sphingolipid that is critical in the development of blood vessels, and in the adult regulates vascular functions including vascular tone, endothelial integrity, and angiogenesis. Further, S1P may regulate arterial lesions in disease and after injury by controlling leukocyte recruitment and smooth muscle cell
G, Daum, A, Grabski, M A, Reidy
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ESC Heart Failure, 2023 Aims Therapeutic options targeting post‐ischaemic cardiac remodelling are sparse. The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) reduces ischaemia/reperfusion injury.
Amin Polzin +16 more
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Sphingosine 1-phosphate and inflammation [PDF]
International Immunology, 2019 AbstractAbstractSphingosine 1-phosphate (S1P), a sphingolipid mediator, regulates various cellular functions via high-affinity G protein-coupled receptors, S1P1-5. The S1P-S1P receptor signaling system plays important roles in lymphocyte trafficking and maintenance of vascular integrity, thus contributing to the regulation of complex inflammatory ...
Hideru, Obinata, Timothy, Hla
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Sphingosine 1-phosphate signalling [PDF]
Development, 2014 Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival.
Karen, Mendelson +2 more
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Circulation Research, 2006 See related article, pages 731–739 A key question in unlocking the mystery of accelerated atherosclerosis that often accompanies types1 and 2 diabetes and leads to increased incidence and severity of heart attacks and strokes is, what are the precise biochemical and molecular signaling pathways that perturb the diabetic blood vessel leading to ...
Ravichandran Ramasamy +2 more
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Cells, 2020 Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena.
Alexandra Lucaciu +4 more
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Sphingosine 1-Phosphate Signaling at the Skin Barrier Interface
Biology, 2022 Sphingosine 1-phosphate (S1P) is a product of membrane sphingolipid metabolism. S1P is secreted and acts via G-protein-coupled receptors, S1PR1-5, and is involved in diverse cellular functions, including cell proliferation, immune suppression, and ...
Kana Masuda-Kuroki, Anna Di Nardo
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Sphingosine Kinase and Sphingosine 1-Phosphate in Cardioprotection [PDF]
Journal of Cardiovascular Pharmacology, 2009 Activation of sphingosine kinase/sphingosine 1-phosphate-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. Application of exogenous sphingosine 1-phosphate (S1P) in cultured cardiac myocytes subjected to hypoxia or treatment of isolated hearts either before ischemia or at the onset ...
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Sphingosine kinase and sphingosine 1-phosphate in asthma
Bioscience Reports, 2010 Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell membranes, sphingolipids have emerged as sources of important signalling molecules over the past decade.
Wen-Qi, Lai +2 more
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The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications
Tumor Biology, 2017 Elucidating the interaction between cancer and non-cancer cells, such as blood vessels, immune cells, and other stromal cells, in the tumor microenvironment is imperative in understanding the mechanisms underlying cancer progression and metastasis, which
Masato Nakajima +4 more
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