Results 11 to 20 of about 30,263,835 (197)

Sphingosine 1-Phosphate in Renal Diseases [PDF]

Cellular Physiology and Biochemistry, 2013
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Alexander Koch, Josef Pfeilschifter, Andrea Huwiler   +2 more
doaj   +3 more sources

Impaired Sphingosine-1-Phosphate Synthesis Induces Preeclampsia by Deactivating Trophoblastic YAP (Yes-Associated Protein) Through S1PR2 (Sphingosine-1-Phosphate Receptor-2)-Induced Actin Polymerizations [PDF]

, 2021
Incomplete spiral artery remodeling, caused by impaired extravillous trophoblast invasion, is a fundamental pathogenic process associated with malplacentation and the development of preeclampsia.
Yue Wu (1262184), Mingyu Hu (2177308), Li Lin (111038), Louise C Kenny (10123735), Mark D Kilby (8483634), Jiayu Huang (3408389), Chao Tong (389167), Huijia Fu (8719995), Li Wen (169316), Yangxi Zheng (8654490), Philip N Baker (7724603), Hongbo Qi (1370292), Biao Huang (215504), Sisi Li (437128), Xuan Ye (1817743), Yong Fu (699744), Jiujiang Liao (8654865), Ping Xu (122619), Ran Duan (821258), Xiyao Liu (5736281)   +19 more
core   +8 more sources

Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase [PDF]

, 2011
Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade.
Gorshkova, Irina, Usatyuk, Peter, Sabbadini, Roger A, Natarajan, Viswanathan, Kalari, Satish, Pyne, Nigel J, Pyne, Susan, Berdyshev, Evgeny V, Zhao, Yutong, Garcia, Joe G.N.   +9 more
core   +4 more sources

Sphingosine-1-phosphate lyases as novel therapeutic targets in intracellular bacteria [PDF]

, 2016
A critical feature of the pathogenesis of B. pseudomallei is its ability to invade, survive and replicate in both phagocytic and non-phagocytic cells, hence a thorough understanding of this intracellular stage is essential in order to develop novel ...
Rafael Jose Da Silva Custodio (21854618)
core   +6 more sources

Sphingosine-1-Phosphate Attenuates LPS-Induced Inflammatory Cardiac Injury in Association With RASGRP1-S100A9-NLRP3 Signaling. [PDF]

Drug Dev Res
ABSTRACT Lipopolysaccharide (LPS) induces endotoxemia‐associated inflammatory cardiac injury rather than classical viral or autoimmune myocarditis. Sphingosine‐1‐phosphate (S1P) regulates cardiovascular and immune responses, predominantly through S1P receptors, but whether it also modulates macrophage‐associated inflammatory signaling during LPS ...
Yue C, Li Q, Li C, Yang T, Huang X, Yue F, Long Q, Li R, Lei R, Ma Q, Hu C, Yang Q, Yan Y, Liu Y, Yan Q, Yang M.   +15 more
europepmc   +2 more sources

Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis [PDF]

, 2012
Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1-phosphate (S1P), thereby promoting oncogenic processes.
Zangemeister-Wittke, Uwe, Fabbro, Doriano, Doriano Fabbro, Huwiler Andrea, Zangemeister-Wittke Uwe, Huwiler, Andrea, Uwe Zangemeister-Wittke, Kotelevets Nataliya, Nataliya Kotelevets (156133), Kotelevets, Nataliya, Nataliya Kotelevets, Andrea Huwiler, Doriano Fabbro (156139), Andrea Huwiler (156145), Uwe Zangemeister-Wittke (156150), Fabbro Doriano   +15 more
core   +2 more sources

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
Kleuser, Burkhard (Prof. Dr. rer. nat.), Radeke, Heinfried H., Japtok, Lukasz, Heinfried H Radeke, Kleuser, Burkhard, Jeong, Se Kyoo, Wolfgang Bäumer, Burkhard Kleuser, Katrin Schaper, Heinfried H. Radeke, Schaper, Katrin, Lukasz Japtok, Bäumer, Wolfgang, Se Kyoo Jeong   +13 more
core   +1 more source

Cardioprotective Properties of Human Platelets Are Lost in Uncontrolled Diabetes Mellitus: A Study in Isolated Rat Hearts

Frontiers in Physiology, 2018
Platelets affect myocardial damage from ischemia/reperfusion. Redox-dependent sphingosine-1-phosphate production and release are altered in diabetic platelets. Sphingosine-1-phosphate is a double-edged sword for ischemia/reperfusion injury. Therefore, we
Isabella Russo, Saveria Femminò, Saveria Femminò, Cristina Barale, Francesca Tullio, Francesca Tullio, Stefano Geuna, Franco Cavalot, Franco Cavalot, Pasquale Pagliaro, Pasquale Pagliaro, Claudia Penna, Claudia Penna   +12 more
doaj   +1 more source

Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells.

PLoS ONE, 2014
Given that the bioactive lipid sphingosine 1-phosphate is involved in cardiovascular pathophysiology, and since lipid accumulation and inflammation are hallmarks of calcific aortic stenosis, the role of sphingosine 1-phosphate on the pro-inflammatory/pro-
Isabel Fernández-Pisonero, Javier López, Esther Onecha, Ana I Dueñas, Patricia Maeso, Mariano Sánchez Crespo, José Alberto San Román, Carmen García-Rodríguez   +7 more
doaj   +1 more source

Fingolimod modulates microglial activation to augment markers of remyelination [PDF]

, 2011
Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell ...
Giovannoni Gavin, Jackson Samuel J, Jackson, SJ, Baker, D, Gavin Giovannoni, Baker David, Giovannoni, G, David Baker, Samuel J Jackson   +8 more
core   +1 more source