Results 31 to 40 of about 37,595 (198)
Sphingosine-1-Phosphate in the Tumor Microenvironment: A Signaling Hub Regulating Cancer Hallmarks
Cells, 2020 As a key hub of malignant properties, the cancer microenvironment plays a crucial role intimately connected to tumor properties. Accumulating evidence supports that the lysophospholipid sphingosine-1-phosphate acts as a key signal in the cancer ...
Laura Riboni +5 more
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The Golgi-localized sphingosine-1-phosphate phosphatase is indispensable for Leishmania major
Scientific Reports, 2022 Sphingosine-1-phosphate phosphatase (SPP) catalyzes the dephosphorylation of sphingosine-1-phosphate (S1P) into sphingosine, the reverse reaction of sphingosine kinase.
Brian Okundaye +3 more
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Cells, 2022 The purpose of this study was to investigate the role of sphingosine kinase 1 (SphK1), which generates sphingosine-1-phosphate (S1P), in corneal neovascularization (NV).
Joseph L. Wilkerson +9 more
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The Anti-Infectious Role of Sphingosine in Microbial Diseases
Cells, 2021 Sphingolipids are important structural membrane components and, together with cholesterol, are often organized in lipid rafts, where they act as signaling molecules in many cellular functions.
Yuqing Wu +3 more
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Sphingosine‐1‐phosphate and renal vasoconstriction [PDF]
Acta Physiologica, 2017 In the present issue of Acta Physiologica, Guan et al. in their article “Mechanisms of sphingosine-1-phosphate-mediated vasoconstriction of rat afferent arterioles” 1 address the signaling events associated with sphingosine-1-phosphate (S1P)-mediated renal afferent vasoconstriction and show in, technically demanding, blood-perfused juxtamedullary ...
openaire +2 more sources
Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling
Journal of Lipid Research, 2009 The sphingolipid metabolite sphingosine-1-phosphate (S1P) and the kinases that produce it have emerged as critical regulators of numerous fundamental biological processes important for health and disease.
Michael Maceyka +2 more
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Endothelial Functions of Sphingosine-1-phosphate
Cellular Physiology and Biochemistry, 2010 The biologically active sphingolipid sphingosine-1-phosphate (S1P) plays key functions in the immune, inflammatory, and cardiovascular systems. In the vasculature, S1P and its receptors are involved in vessel morphogenesis and angiogenesis during embryonic development and in the adult organism both under normal and pathological conditions.
Lucke, Susann, Levkau, Bodo
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Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants
Annals of Clinical and Translational Neurology, EarlyView.Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold +12 more
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Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases
Liver Research, 2019 The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitioning. Obesity, dyslipidemia and metabolic disorders are of increasing public health concern worldwide, and ...
Eric K. Kwong, Huiping Zhou
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Effects of sphingolipid metabolism disorders on endothelial cells
Lipids in Health and Disease, 2022 Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai +4 more
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