Results 51 to 60 of about 30,263,835 (197)
Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking
Cell Reports, 2016 Sphingosine kinase 1 (Sphk1) associates with early endocytic membranes during endocytosis; however, the role of sphingosine or sphingosine-1-phosphate as the critical metabolite in endocytic trafficking has not been established. Here, we demonstrate that
Megan M. Young +5 more
doaj +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita +4 more
wiley +1 more source
Rôle de la sphingosine 1-phosphate dans les interactions mélanome-stroma [PDF]
, 2012 Le mélanome métastatique demeure un cancer au sombre pronostic, et aucune des thérapies conventionnelles n'a pu apporter de bénéfice sur la survie globale.
Albinet, Virginie
core
Roles of sphingosine 1-phosphate on tumorigenesis
, 2011 [[abstract]]Roles of sphingosine 1-phosphate on ...
黃元勵;Huang, Yuan-Li, Yuan-Li Huang
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Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity.
PLoS ONE, 2019 Systemic lupus erythematous (SLE) is a chronic multi-organ autoimmune disease. Genetic and environmental factors contribute to disease onset and severity.
Samar M Hammad +5 more
doaj +1 more source
Journal of Lipid Research, 2009 Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, stimulates proliferation and contractility in hepatic stellate cells, the principal matrix-producing cells in the liver, and inhibits proliferation via S1P receptor 2 (S1P2) in hepatocytes in ...
Hitoshi Ikeda +14 more
doaj +1 more source
Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis
British Journal of Clinical Pharmacology, EarlyView.Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley +1 more source
Journal of Extracellular VesiclesEpidermal permeability barrier defects are associated with several skin diseases, including atopic dermatitis (AD). Using an AD mouse model, we previously demonstrated that topically administered small extracellular vesicles (sEVs) (prepared following ...
Kyong‐Oh Shin +15 more
doaj +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator [PDF]
, 2011 Sphingosine-1-phosphate (S1P) acts as high affinity agonist at specific G-protein-coupled receptors, S1P(1-5), that play important roles e.g. in the cardiovascular and immune systems.
Bianca Hegen +18 more
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