Results 61 to 70 of about 66,817 (240)

Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1 [PDF]

, 2018
Sphingosine kinase 1 (SphK1) upregulation is associated with pathologic pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), but the mechanisms controlling its expression are undefined.
Chen, Jiwang, Comhair, Suzy, Machado, Roberto F., Natarajan, Viswanathan, Singla, Sunit, Sysol, Justin R., Zhao, Shuangping   +6 more
core   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

The emerging role of FTY720 (Fingolimod) in cancer treatment [PDF]

, 2016
FTY720 (Fingolimod) is a clinically approved immunomodulating therapy for multiple sclerosis that sequesters T-cells to lymph nodes through functional antagonism of sphingosine-1-phosphate 1 receptor.
Abdollahi, Alewijnse, Alexander, Aradhye, Arai, Arlinghaus, Bae, Baumruker, Baxter, Ben-Sasson, Bohler, Bollen, Braun, Brinkmann, Broek, Brune, Brune, Bueno, Bueno, Bueno, Burtin, Byrd, Cabot, Campochiaro, Chauhan, Chen, Chiba, Curino, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cuvillier, Cyster, Cyster, Edwards, Eshhar, Fan, Fan, Fan, Fan, Ferrer, Gajewski, Garcia, Garcia-Foncillas, Garcia-Foncillas, Geilen, Grech, Greten, Habib, Hahn, Hakomori, Hakomori, Hakomori, Han, Han, Hanessian, Hannun, Hannun, He, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hla, Hoshino, Huang, Huwiler, Huwiler, Huwiler, Huyton, Ibrahim, Igarashi, Igarashi, Igarashi, Jaffrezou, Kappos, Karliner, Karliner, Kasahara, Katsuoka, Katsuoka, Katsuoka, Kaufmann, Klostergaard, Kohama, Kordula, Kornblau, Lee, Lee, Lei, Lei, Li, Liao, Lichter, Liu, Liu, Liu, Lynch, Lynch, Lynch, Macdonald, Marcucci, Masood, Matsuyama, May, May, Moolenaar, Morisaki, Mosser, Muthusamy, Muthusamy, Muthusamy, Nakamura, Neviani, Neviani, Nozawa, Nozawa, Nussbaumer, Obeid, Obeid, Obeid, Obeid, Oberlies, Odero, Ogretmen, Ohdan, Okumoto, Okuyama, Park, Pchejetski, Pchejetski, Phelps, Pitson, Pitson, Pitson, Pollard, Prior, Proia, Proia, Pyne, Pyne, Pyne, Pyne, Pyne, Pyne, Rader, Radue, Rennard, Rodrigues, Rosen, Rosen, Roy, Ruefli-Brasse, Sabbadini, Sakaguchi, Sanchez, Satoh, Schmouder, Schwartz, Seishima, Sharma, Shinomiya, Shinomiya, Shinomiya, Shinomiya, Shinomiya, Smith, Smith, Song, Song, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Spiegel, Stracke, Stracke, Stracke, Sun, Suzuki, Suzuki, Tagliaferri, Tagliaferri, Takahara, Takuwa, Takuwa, Taniwaki, Tornquist, Troncone, Uesato, Vadas, Vadas, Vadas, Vadas, Verrills, Walsh, Wang, Wang, Wattenberg, Wattenberg, Waxman, Weichselbaum, Wiedermann, Wolf, Wong, Wong, Wood, Woodcock, Wu, Xia, Xia, Xia, Xia, Xu, Xu, Yap, Yee, Yun, Yun, Zangemeister-Wittke, Zawadzke, Zheng, Zheng   +249 more
core   +6 more sources

Sphingosine kinases : emerging structure function insights [PDF]

, 2016
Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function.
Adams, David R., Pyne, Nigel J., Pyne, Susan   +2 more
core   +1 more source

Sphingosine kinase 1 in breast cancer: A new molecular marker and a therapy target [PDF]

, 2020
It is now well-established that sphingosine kinase 1 (SK1) plays a significant role in breast cancer development, progression, and spread, whereas SK1 knockdown can reverse these processes.
Alshaker, Heba, Pchejetski, Dmitri, Thrower, Hannah   +2 more
core   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells. [PDF]

, 2009
The cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the ...
Cyster, Jason G, Grigorova, Irina L, Okada, Takaharu, Pham, Trung HM, Phan, Tri Giang, Schwab, Susan R   +5 more
core  

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking

Cell Reports, 2016
Sphingosine kinase 1 (Sphk1) associates with early endocytic membranes during endocytosis; however, the role of sphingosine or sphingosine-1-phosphate as the critical metabolite in endocytic trafficking has not been established. Here, we demonstrate that
Megan M. Young, Yoshinori Takahashi, Todd E. Fox, Jong K. Yun, Mark Kester, Hong-Gang Wang   +5 more
doaj   +1 more source

Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. [PDF]

, 2006
Activated protein C (APC) has emerged as a novel therapeutic agent for use in selected patients with severe sepsis, even though the mechanism of its benefit is not well established.
Looney, Mark R, Matthay, Michael A
core   +2 more sources