Results 101 to 110 of about 47,887 (228)

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, EarlyView.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain [PDF]

, 2017
Our previous findings suggest that sphingosine kinase 2 (SPK2) mediates ischemic tolerance and autophagy in cerebral preconditioning. The aim of this study was to determine by which mechanism SPK2 activates autophagy in neural cells.
Chen, Jia-Li, Qin, Zheng-Hong, Sheng, Rui, Song, Dan-Dan, Waeber, Christian, Xia, Yun-Fei, Zhang, Tong-Tong   +6 more
core   +1 more source

Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 678-687, March 2026.
Vascular leakage and its associated phenomena vasodilation and endothelial activation are pathophysiological features of various diseases. Multiple drug candidates targeting these phenomena are in development, necessitating translational models to demonstrate proof‐of‐pharmacology and proof‐of‐mechanism in early‐phase clinical trials.
Marella Cornelia Elizabeth van Ruissen, Menno van Diemen, Liza Botros, Ingrid Tomljanovic, Hind Achbo, Dimitra Eleftheriou, Paul Willem Schenk, Naomi Bertine Klarenbeek, Derek William Gilroy, Manon Aleida Adriana Jansen, Matthijs Moerland   +10 more
wiley   +1 more source

Combination of RAD001 (everolimus) and docetaxel reduces prostate and breast cancer cell VEGF production and tumour vascularisation independently of sphingosine-kinase-1 [PDF]

, 2017
Resistance to docetaxel is a key problem in current prostate and breast cancer management. We have recently discovered a new molecular mechanism of prostate cancer docetaxel chemoresistance mediated by the mammalian target of rapamycin (mTOR)/sphingosine-
A Datta, AT Oosterom van, B Malavaud, C Hwang, C Ortholan, D Bufalo Del, D Pchejetski, D Pchejetski, D Pchejetski, D Pchejetski, D Pchejetski, H Alshaker, H Alshaker, H Alshaker, H Alshaker, H Zhong, HL Goel, J Dancey, K Heo, L Sauer, M Guba, M Liu, M Nagahashi, MA Khan, N Kozakowski, R Bianco, RA Madan, RJ Motzer, S Murray, S Walsh, SM Pitson, T Weichhart, U Saran, X Zhang   +33 more
core   +1 more source

Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression

Glia, Volume 74, Issue 3, March 2026.
Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Carla Peiró‐Moreno, Juan Carlos Chara, Katy Marshall‐Phelps, Irune Ugarte‐Arakistain, Stefano Calovi, Rafael Gois De Almeida, María Domercq, Carlos Matute   +7 more
wiley   +1 more source

Open field study of some Zea mays hybrids, lipid compounds and fumonisins accumulation [PDF]

, 2015
Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions.
Battilani, Paola, Cirlini, Martin, Dall’Asta, Chiara, Fanelli, Corrado, Galaverna, Gianni, Giorni, Paola, Ludovici, Matteo, Reverberi, Massimo, Scala, Valeria   +8 more
core   +2 more sources

The role of cytokines in ovarian cancer drug resistance

International Journal of Cancer, Volume 158, Issue 4, Page 821-834, 15 February 2026.
Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Lu Wang, Yunxia Zang, Rebeka Dejenie, Junyuan Bing, Shixia Dong, Yanfei Zhang, Yi Zhu, Jingjing Li   +7 more
wiley   +1 more source

Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis

EMBO Molecular Medicine, 2012
Mechanisms that alter protein phosphatase 2A (PP2A)‐dependent lung tumour suppression via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour suppressor ceramide binds I2PP2A/SET selectively in the nucleus and including its K209 and Y122
Sahar A. Saddoughi, Salih Gencer, Yuri K. Peterson, Katherine E. Ward, Archana Mukhopadhyay, Joshua Oaks, Jacek Bielawski, Zdzislaw M. Szulc, Raquela J. Thomas, Shanmugam P. Selvam, Can E. Senkal, Elizabeth Garrett‐Mayer, Ryan M. De Palma, Dzmitry Fedarovich, Angen Liu, Amyn A. Habib, Robert V. Stahelin, Danilo Perrotti, Besim Ogretmen   +18 more
doaj   +1 more source

SphK1/S1P信号通路在脑缺血再灌注神经细胞损伤机制中的研究进展 Progress of SphK1/S1P Signaling Pathway in the Mechanism of Cerebral Ischemia Reperfusion Injury

Zhongguo cuzhong zazhi, 2018
神经鞘磷脂及其代谢产物——神经酰胺、鞘氨醇（sphingosine，Sph）、鞘氨醇-1-磷酸 （sphingosine-1-phosphate，S1P）作为重要的信号传递分子在细胞增殖、存活、凋亡及炎症免疫等病理生 理过程中发挥重要作用，鞘氨醇激酶（sphingosine kinase，SphK）是催化Sph生成S1P的关键酶。脑缺血再 灌注损伤涉及兴奋性毒性、神经炎症及氧化应激、自由基生成、血脑屏障损伤、细胞死亡等多种机 制。本文主要阐述SphK1及S1P的功能特点，及脑缺血再灌注损伤涉及的机制 ...
李轼，吕蔓华
doaj   +1 more source