Results 121 to 130 of about 47,887 (228)

Flow dynamics control the effect of sphingosine-1-phosphate on endothelial permeability in a microfluidic vessel bifurcation model [PDF]

, 2018
Blood vessels are lined by endothelial cells that form a semipermeable barrier to restrict fluid flow across the vessel wall. The endothelial barrier is known to respond to various molecular mechanisms, but the effects of mechanical signals that arise ...
Spychalski, Griffin
core  

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Psychosine Alleviates Colitis via Inhibiting Th1 and Th17 Cell Immune Responses in Inflammatory Bowel Diseases

Journal of Gastroenterology and Hepatology, Volume 41, Issue 2, Page 686-695, February 2026.
ABSTRACT Background Aberrant T‐helper 1 (Th1) and Th17 cell activation is involved in the pathogenesis of inflammatory bowel disease (IBD). Psychosine is known to induce apoptosis, promote astrocyte activation, and inhibit osteoclastogenesis. However, the role of psychosine on Th1 and Th17 cell immune responses has not been previously reported. In this
Ritian Lin, Jiayi Tu, Shan Li, Qinjuan Sun, Lan Zhong   +4 more
wiley   +1 more source

Sphingosine kinase inhibitors: A patent review

International Journal of Molecular Medicine, 2018
Sphingosine kinases (SphKs) catalyze the conversion of the sphingosine to the promitogenic/migratory product, sphingosine-1-phosphate (S1P). SphK/S1P pathway has been linked to the progression of cancer and various other diseases including allergic inflammatory disease, cardiovascular diseases, rejection after transplantation, the central nervous ...
Mengda, Cao, Chunmei, Ji, Yanjun, Zhou, Wen, Huang, Weiwei, Ni, Xunliang, Tong, Ji-Fu, Wei   +6 more
openaire   +3 more sources

A Somatic Mutation in HIF‐2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
A mutation within the C‐terminal transactivation domain of HIF‐2α enhances Cd36 expression by increased transactivation activity, leading to ceramide accumulation and disruption of glucose and lipid metabolism. Inhibition of ceramide synthesis by myriocin reduces ceramide levels and ameliorates these metabolic disturbances.
Feiqiong Gao, Xudong Feng, Qigu Yao, Weiqin Ji, Xinying Zhang, Qiaoling Pan, Bin Zhu, Jiong Yu, Hongcui Cao, Xianfeng Zhang   +9 more
wiley   +1 more source

Acid ceramidase-1 (ASAH1/aCDase) an important for anticancer drug discovery: a review

Future Journal of Pharmaceutical Sciences
Background Dysregulated sphingolipid metabolism has emerged as a major pathway in multiple human cancers. Sphingolipids are major structural components of cell membranes, playing key roles in maintaining structural integrity, fluidity, and barrier ...
Seemarani M. Pawar, Trupti Chitre, Prasad Dandawate   +2 more
doaj   +1 more source

Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase.

The Journal of biological chemistry, 2000
Sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate (S1P), a lipid messenger that plays an important role in a variety of mammalian cell processes, including inhibition of apoptosis and stimulation of cell proliferation. Basal levels of S1P in cells are generally low but can increase rapidly when cells are exposed to various ...
S M, Pitson, P A, Moretti, J R, Zebol, P, Xia, J R, Gamble, M A, Vadas, R J, D'Andrea, B W, Wattenberg   +7 more
openaire   +1 more source

Sphingosine kinase 1 as an anticancer therapeutic target

Drug Design, Development and Therapy, 2015
Ying Gao,1,* Fei Gao,2,* Kan Chen,3,* Mei-li Tian,1 Dong-li Zhao1 1Department of Radiotherapy Oncology, First Affiliated Hospital of Xi’an Jiaotong University, 2Department of Neurology, First Affiliated Hospital of Xi’an Medical University ...
Gao Y, Gao F, Chen K, Tian ML, Zhao DL
doaj  

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence. [PDF]

, 2019
Although aging is considered to be an unavoidable event, recent experimental evidence suggests that the process can be counteracted. Intracellular calcium (Ca2+i) dyshomeostasis, mitochondrial dysfunction, oxidative stress, and lipid dysregulation are ...
Bomba, Manuela, Castelli, Vanessa, Cicalini, Ilaria, Cimini, Annamaria, d'Aurora, Marco, Del Boccio, Piero, Gatta, Valentina, Granzotto, Alberto, Massetti, Noemi, Navarra, Riccardo, Onofrj, Marco, Piomelli, Daniele, Sensi, Stefano L   +12 more
core  

Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide-related activation

Biologics: Targets & Therapy, 2008
Yunbo Ke, R John SolaroDepartment of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USAAbstract: The p21 activated kinase-1 (Pak1) is a serine-threonine protein kinase directly activated by ...
Yunbo Ke, R John Solaro
doaj