Results 181 to 190 of about 47,887 (228)

Combined Antitumor Effect of the Serine Protease Urokinase Inhibitor Upamostat and the Sphingosine Kinase 2 Inhibitor Opaganib on Cholangiocarcinoma Patient-Derived Xenografts. [PDF]

Cancers (Basel)
Asumda FZ, Campbell NA, Hassan MA, Fathi R, Vasquez Rico DF, Kiem M, Vang EV, Kim YH, Luo X, O'Brien DR, Buhrow SA, Reid JM, Moore MJ, Ben-Yair VK, Levitt ML, Leiting JL, Abdelrahman AM, Zhu X, Lucien F, Truty MJ, Roberts LR.   +20 more
europepmc   +1 more source

Expression of Concern: miRNA-103 promotes chondrocyte apoptosis by downregulation of Sphingosine kinase-1 and ameliorates PI3K/AKT pathway in osteoarthritis. [PDF]

Biosci Rep
europepmc   +1 more source

Inhibition of Sphingosine Kinase 1 Reduces Sphingosine-1-Phosphate and Exacerbates Amyloid-Beta-Induced Neuronal Cell Death in Mixed-Glial-Cell Culture. [PDF]

Neurol Int
Minamihata T, Takano-Kawabe K, Moriyama M.   +2 more
europepmc   +1 more source

Assessment of the Effects of Sphingosine Kinase 1/Sphingosine-1-Phosphate on Microangiogenesis at Rat Myofascial Trigger Points Using Contrast-Enhanced Ultrasonography. [PDF]

J Pain Res
Fang X, Yin Y, Lun H, Liu Y, Zhu S.
europepmc   +1 more source

[Sphingosine kinase-1 regulates migration and invasion of gastric cancer cells via targeting the nuclear factor-κB signaling pathway]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Ling Q, Ji K, Chen J, Guan J, Wang R, Man W, Zhu B.   +6 more
europepmc   +1 more source

Sphingosine kinase 1-specific inhibitor PF543 reduces goblet cell metaplasia of bronchial epithelium in an acute asthma model.

Am J Physiol Lung Cell Mol Physiol
Sudhadevi T, Ackerman SJ, Jafri A, Basa P, Ha AW, Natarajan V, Harijith A.   +6 more
europepmc   +1 more source

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Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics

Prostaglandins & Other Lipid Mediators, 2005
It has become abundantly clear over the past decade that sphingolipids and their metabolites are key signaling molecules. Ceramide, the backbone of all sphingolipids, predominantly inhibits cell growth and induces apoptosis, while its metabolite, sphingosine-1-phosphate promotes growth and survival.
Michael, Maceyka, Sheldon, Milstien, Sarah, Spiegel   +2 more
openaire   +2 more sources

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
The sphingolipid metabolites ceramide (Cer), sphingosine (Sph), and sphingosine-1-phosphate (S1P) play an important role in the regulation of cell proliferation, survival, and cell death. Cer and Sph usually inhibit proliferation and promote apoptosis, while the further metabolite S1P stimulates growth and suppresses apoptosis.
Michael, Maceyka, Shawn G, Payne, Sheldon, Milstien, Sarah, Spiegel   +3 more
openaire   +2 more sources

Sphingosine Kinases Signalling in Carcinogenesis

Mini-Reviews in Medicinal Chemistry, 2015
Sphingosine kinases (Sphk1 and 2) regulate the prodution of sphingosine-1-phosphate (S1P), that is key molecule in cancer development. SphK1, which is commonly overexpressed in malignant tumours, significantly contributes to the pathogenesis of various types of cancer as well as to resistance to different Tyrosine Kinase inibitors (TKIs).
Gabriella, Marfe, Giovanna, Mirone, Arvind, Shukla, Carla, Di Stefano   +3 more
openaire   +2 more sources