Genomic and transcriptomic analyses support a silk gland origin of spider venom glands [PDF]
BMC Biology, 2023 Background Spiders comprise a hyperdiverse lineage of predators with venom systems, yet the origin of functionally novel spider venom glands remains unclear.
Bingyue Zhu +5 more
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Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications [PDF]
Molecules, 2023 Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity, with 47,000 described species and an estimated 150,000 species in existence. Evolving with intricate venom, spiders are nature’s skilled predators.
Ruiyin Guo +5 more
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Enlightening the toxinological dark matter of spider venom enzymes [PDF]
npj BiodiversitySpiders produce highly adapted venoms featuring a complex mixture of biomolecules used mainly for hunting and defense. The most prominent components are peptidic neurotoxins, a major focus of research and drug development, whereas venom enzymes have been
Josephine Dresler +3 more
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A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate. [PDF]
Mol Pharmacol, 2023 A special category of phospholipase D (PLD) in the venom of the brown recluse spider (Loxosceles reclusa) and several other sicariid spiders accounts for the dermonecrosis and many of the other clinical symptoms of envenomation.
Lachmayr H, Merrill AH.
europepmc +4 more sources
A roadmap to the enzymes from spider venom: biochemical ecology, molecular diversity, and value for the bioeconomy [PDF]
Frontiers in Arachnid ScienceSpiders are ancient and highly successful predators, which use venom for both predation and defense. Their venoms are complex mixtures of potent biological molecules, emerging as a prolific source of biomolecular innovation in agriculture, biomedicine ...
Josephine Dresler +14 more
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Complex precursor structures of cytolytic cupiennins identified in spider venom gland transcriptomes [PDF]
Scientific Reports, 2021 Analysis of spider venom gland transcriptomes focuses on the identification of possible neurotoxins, proteins and enzymes. Here, the first comprehensive transcriptome analysis of cupiennins, small linear cationic peptides, also known as cytolytic or ...
Lucia Kuhn-Nentwig
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Can we resolve the taxonomic bias in spider venom research? [PDF]
Toxicon: X, 2019 The rate of discovery of new spider species greatly exceeds the rate of spider venom characterisation, leading to an increasing number of species with unstudied venoms.
Volker Herzig +2 more
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The deep-rooted origin of disulfide-rich spider venom toxins. [PDF]
Elife, 2023 Spider venoms are a complex concoction of enzymes, polyamines, inorganic salts, and disulfide-rich peptides (DRPs). Although DRPs are widely distributed and abundant, their bevolutionary origin has remained elusive.
Shaikh NY, Sunagar K.
europepmc +2 more sources
Brown Spider Venom Phospholipase-D Activity upon Different Lipid Substrates. [PDF]
Toxins (Basel), 2023 Brown spider envenomation results in dermonecrosis, characterized by an intense inflammatory reaction. The principal toxins of brown spider venoms are phospholipase-D isoforms, which interact with different cellular membrane components, degrade ...
Chaves-Moreira D +9 more
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Frontiers in Molecular Biosciences, 2023 Introduction: Spider venoms are a unique source of bioactive peptides, many of which display remarkable biological stability and neuroactivity. Phoneutria nigriventer, often referred to as the Brazilian wandering spider, banana spider or “armed” spider ...
F. C. Cardoso +6 more
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