Genomic and transcriptomic analyses support a silk gland origin of spider venom glands [PDF]
BMC Biology, 2023 Background Spiders comprise a hyperdiverse lineage of predators with venom systems, yet the origin of functionally novel spider venom glands remains unclear.
Bingyue Zhu +5 more
doaj +3 more sources
Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications [PDF]
Molecules, 2023 Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity, with 47,000 described species and an estimated 150,000 species in existence. Evolving with intricate venom, spiders are nature’s skilled predators.
Ruiyin Guo +5 more
doaj +3 more sources
Enlightening the toxinological dark matter of spider venom enzymes [PDF]
npj BiodiversitySpiders produce highly adapted venoms featuring a complex mixture of biomolecules used mainly for hunting and defense. The most prominent components are peptidic neurotoxins, a major focus of research and drug development, whereas venom enzymes have been
Josephine Dresler +3 more
doaj +3 more sources
The deep-rooted origin of disulfide-rich spider venom toxins [PDF]
eLife, 2023 Spider venoms are a complex concoction of enzymes, polyamines, inorganic salts, and disulfide-rich peptides (DRPs). Although DRPs are widely distributed and abundant, their bevolutionary origin has remained elusive.
Naeem Yusuf Shaikh, Kartik Sunagar
doaj +3 more sources
Complex precursor structures of cytolytic cupiennins identified in spider venom gland transcriptomes [PDF]
Scientific Reports, 2021 Analysis of spider venom gland transcriptomes focuses on the identification of possible neurotoxins, proteins and enzymes. Here, the first comprehensive transcriptome analysis of cupiennins, small linear cationic peptides, also known as cytolytic or ...
Lucia Kuhn-Nentwig
doaj +3 more sources
Can we resolve the taxonomic bias in spider venom research? [PDF]
Toxicon: X, 2019 The rate of discovery of new spider species greatly exceeds the rate of spider venom characterisation, leading to an increasing number of species with unstudied venoms.
Volker Herzig +2 more
doaj +3 more sources
Spider Venom: Components, Modes of Action, and Novel Strategies in Transcriptomic and Proteomic Analyses [PDF]
Toxins, 2019 This review gives an overview on the development of research on spider venoms with a focus on structure and function of venom components and techniques of analysis.
Nicolas Langenegger +2 more
doaj +3 more sources
Structure–Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels [PDF]
Frontiers in Pharmacology, 2019 Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that exhibit unique pharmacological properties to modulate key membrane protein targets.
Fernanda C. Cardoso, Richard J. Lewis
doaj +3 more sources
Transcriptomic Analysis of the Spider Venom Gland Reveals Venom Diversity and Species Consanguinity [PDF]
Toxins, 2019 Selenocosmia jiafu (S. jiafu) has been recently identified as a new species of spider in China. It lives in the same habitat as various other venomous spiders, including Chilobrachys jingzhao (C. jingzhao), Selenocosmia huwena (S. huwena), and Macrothele
Zhaotun Hu +4 more
doaj +3 more sources
A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate. [PDF]
Mol Pharmacol, 2023 A special category of phospholipase D (PLD) in the venom of the brown recluse spider (Loxosceles reclusa) and several other sicariid spiders accounts for the dermonecrosis and many of the other clinical symptoms of envenomation.
Lachmayr H, Merrill AH.
europepmc +2 more sources