Origin and Characterization of Extracellular Vesicles Present in the Spider Venom of Ornithoctonus hainana. [PDF]
Toxins (Basel), 2021 Extracellular vesicles (EVs), including exosomes and microvesicles, are membranous vesicles released from nearly all cellular types. They contain various bioactive molecules, and their molecular composition varies depending on their cellular origin.
Xun C +8 more
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Selective Targeting of Nav1.7 with Engineered Spider Venom-Based Peptides. [PDF]
Channels (Austin), 2021 A fundamental mechanism that drives the propagation of electrical signals in the nervous system is the activation of voltage-gated sodium channels. The sodium channel subtype Nav1.7 is critical for the transmission of pain-related signaling, with gain-of-
Neff RA, Wickenden AD.
europepmc +2 more sources
Brown spider venom toxins: what are the functions of astacins, serine proteases, hyaluronidases, allergens, TCTP, serpins and knottins? [PDF]
J Venom Anim Toxins Incl Trop Dis, 2021 Accidents caused by the bites of brown spiders (Loxosceles) generate a clinical condition that often includes a threatening necrotic skin lesion near the bite site along with a remarkable inflammatory response.
Gremski LH +10 more
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Prospective Use of Brown Spider Venom Toxins as Therapeutic and Biotechnological Inputs. [PDF]
Front Mol Biosci, 2021 Brown spider (genus Loxosceles) venoms are mainly composed of protein toxins used for predation and defense. Bites of these spiders most commonly produce a local dermonecrotic lesion with gravitational spread, edema and hemorrhage, which together are ...
Gremski LH +9 more
europepmc +2 more sources
Toxicological Characterization and Phospholipase D Activity of the Venom of the Spider Sicarius thomisoides [PDF]
Toxins, 2020 Envenomation by Loxosceles spiders (Sicariidae family) has been thoroughly documented. However, little is known about the potential toxicity of members from the Sicarius genus.
Tomás Arán-Sekul +7 more
doaj +2 more sources
Toxicon: X, 2020 Spiders use their venom for defence and to capture prey. These venoms contain a cocktail of biologically active compounds that display several different biological activities, such as large molecules and small molecules including peptides, proteins ...
Pornsawan Khamtorn +6 more
doaj +2 more sources
A Proteomics and Transcriptomics Investigation of the Venom from the Barychelid Spider Trittame loki (Brush-Foot Trapdoor) [PDF]
Toxins, 2013 Although known for their potent venom and ability to prey upon both invertebrate and vertebrate species, the Barychelidae spider family has been entirely neglected by toxinologists. In striking contrast, the sister family Theraphosidae (commonly known as
Eivind A. B. Undheim +12 more
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Venomous spiders of Albania -does an increase of temperature influence the toxicity of spider venom? [PDF]
Toxicon X, 2022 Black widow spiders (Latrodectus sp.) are distributed worldwide, and in Albania the L. tredecimguttatus Rossi, 1790 has been the dominant spider. Other medically important spiders in Albania include the brown recluse with symptoms known as loxoscelism, the false black widow and the egg sac spiders; the last two inducing similar symptoms to a wasp sting.
Vrenozi, Blerina.
europepmc +4 more sources
Phlogiellus bundokalbo spider venom: cytotoxic fractions against human lung adenocarcinoma (A549) cells [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: Spider venom is a potential source of pharmacologically important compounds. Previous studies on spider venoms reported the presence of bioactive molecules that possess cell-modulating activities.
Anna Beatriz R. Mayor +3 more
doaj +3 more sources
Forty Years of the Description of Brown Spider Venom Phospholipases-D. [PDF]
Toxins (Basel), 2020 Spiders of the genus Loxosceles, popularly known as Brown spiders, are considered a serious public health issue, especially in regions of hot or temperate climates, such as parts of North and South America.
Gremski LH +9 more
europepmc +2 more sources